Plasmalemmal Na+/Ca2+ exchanger modulates Ca2+-dependent exocytotic release of glutamate from rat cortical astrocytes [0.03%]
大鼠皮质星形胶质细胞浆膜Na+/Ca2+交换蛋白调节谷氨酸的钙依赖性胞吐释放作用
Reno C Reyes,Alexei Verkhratsky,Vladimir Parpura
Reno C Reyes
Astroglial excitability operates through increases in Ca2+cyt (cytosolic Ca2+), which can lead to glutamatergic gliotransmission. In parallel fluctuations in astrocytic Na+cyt (cytosolic Na+) control metabolic neuronal-glial signalling, mos...
Altered synaptic marker abundance in the hippocampal stratum oriens of Ts65Dn mice is associated with exuberant expression of versican [0.03%]
Ts65Dn小鼠海马CA1区stratum oriens突触标记物丰度改变与versican表达增加有关
Matthew D Howell,Paul E Gottschall
Matthew D Howell
DS (Down syndrome), resulting from trisomy of chromosome 21, is the most common cause of genetic mental retardation; however, the molecular mechanisms underlying the cognitive deficits are poorly understood. Growing data indicate that chang...
Non-cell autonomous influence of the astrocyte system xc- on hypoglycaemic neuronal cell death [0.03%]
谷氨酸转运体系统XC-在糖皮质激素诱导的神经元凋亡中的非自主作用
Nicole A Jackman,Shannon E Melchior,James A Hewett et al.
Nicole A Jackman et al.
Despite longstanding evidence that hypoglycaemic neuronal injury is mediated by glutamate excitotoxicity, the cellular and molecular mechanisms involved remain incompletely defined. Here, we demonstrate that the excitotoxic neuronal death t...
Sensory neurons derived from diabetic rats have diminished internal Ca2+ stores linked to impaired re-uptake by the endoplasmic reticulum [0.03%]
糖尿病大鼠来源的感觉神经元内储存的钙离子减少与内质网回收功能受损有关
Elena Zherebitskaya,Jason Schapansky,Eli Akude et al.
Elena Zherebitskaya et al.
Distal symmetrical sensory neuropathy in diabetes involves the dying back of axons, and the pathology equates with axonal dystrophy generated under conditions of aberrant Ca2+ signalling. Previous work has described abnormalities in Ca2+ ho...
Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease [0.03%]
阿尔茨海默病三转基因动物模型中早期内侧颞叶皮质星形胶质细胞萎缩
Chia-Yu Yeh,Bhamini Vadhwana,Alexei Verkhratsky et al.
Chia-Yu Yeh et al.
The EC (entorhinal cortex) is fundamental for cognitive and mnesic functions. Thus damage to this area appears as a key element in the progression of AD (Alzheimer's disease), resulting in memory deficits arising from neuronal and synaptic ...
Early effects of lipopolysaccharide-induced inflammation on foetal brain development in rat [0.03%]
脂多糖致炎对胎鼠脑发育早期影响的研究
Cristina A Ghiani,Natalia S Mattan,Hiroko Nobuta et al.
Cristina A Ghiani et al.
Studies in humans and animal models link maternal infection and imbalanced levels of inflammatory mediators in the foetal brain to the aetiology of neuropsychiatric disorders. In a number of animal models, it was shown that exposure to vira...
Increased expression of axogenesis-related genes and mossy fibre length in dentate granule cells from adult HuD overexpressor mice [0.03%]
HuD过表达小鼠海马齿状回颗粒神经元轴突发芽相关基因的表达和苔藓纤维长度的增加
Nora I Perrone-Bizzozero,Daniel C Tanner,Joanna Mounce et al.
Nora I Perrone-Bizzozero et al.
The neuronal RNA-binding protein HuD plays a critical role in the post-transcriptional regulation of short-lived mRNAs during the initial establishment and remodelling of neural connections. We have generated transgenic mice overexpressing ...
Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses [0.03%]
阿尔茨海默病转基因小鼠模型中的多种炎症反应及免疫治疗对其的影响
Donna M Wilcock,Qun Zhao,Dave Morgan et al.
Donna M Wilcock et al.
While the presence of an inflammatory response in AD (Alzheimer's disease) is well known, the data on inflammation are conflicting, suggesting that inflammation either attenuates pathology, exacerbates it or has no effect. Our goal was to m...
YY1 negatively regulates mouse myelin proteolipid protein (Plp1) gene expression in oligodendroglial cells [0.03%]
YY1在少突胶质细胞中负向调节小鼠髓鞘蛋白脂蛋白（Plp1）基因的表达
Olga E Zolova,Patricia A Wight
Olga E Zolova
YY1 (Yin and Yang 1) is a multifunctional, ubiquitously expressed, zinc finger protein that can act as a transcriptional activator, repressor, or initiator element binding protein. Previous studies have shown that YY1 modulates the activity...
Peripheral neuropathy in the Twitcher mouse involves the activation of axonal caspase 3 [0.03%]
Twitcher小鼠外周神经病的发生与轴突中Caspase 3的活化有关
Benjamin Smith,Francesca Galbiati,Ludovico Cantuti Castelvetri et al.
Benjamin Smith et al.
Infantile Krabbe disease results in the accumulation of lipid-raft-associated galactosylsphingosine (psychosine), demyelination, neurodegeneration and premature death. Recently, axonopathy has been depicted as a contributing factor in the p...