IL-1RI (interleukin-1 receptor type I) signalling is essential for host defence and hemichannel activity during acute central nervous system bacterial infection [0.03%]
白细胞介素-1受体I型信号通路在中枢神经系统细菌感染急性期的宿主防御和半通道活性中必不可少
Juan Xiong,Maria Burkovetskaya,Nikolay Karpuk et al.
Juan Xiong et al.
Staphylococcus aureus is a common aetiological agent of bacterial brain abscesses. We have previously established that a considerable IL-1 (interleukin-1) response is elicited immediately following S. aureus infection, where the cytokine ca...
Novel model of neuronal bioenergetics: postsynaptic utilization of glucose but not lactate correlates positively with Ca2+ signalling in cultured mouse glutamatergic neurons [0.03%]
新的神经细胞生物能量模型：在培养的小鼠谷氨酸能神经元中，葡萄糖而非乳酸的利用与Ca2 +信号呈正相关
Lasse K Bak,Linea F Obel,Anne B Walls et al.
Lasse K Bak et al.
We have previously investigated the relative roles of extracellular glucose and lactate as fuels for glutamatergic neurons during synaptic activity. The conclusion from these studies was that cultured glutamatergic neurons utilize glucose r...
Protein carbonylation and aggregation precede neuronal apoptosis induced by partial glutathione depletion [0.03%]
谷胱甘肽部分缺乏诱发的神经元凋亡前蛋白质羰基化和聚集先行发生
Anushka Dasgupta,Jianzheng Zheng,Oscar A Bizzozero
Anushka Dasgupta
While the build-up of oxidized proteins within cells is believed to be toxic, there is currently no evidence linking protein carbonylation and cell death. In the present study, we show that incubation of nPC12 (neuron-like PC12) cells with ...
Delayed administration of VEGF rescues spinal motor neurons from death with a short effective time frame in excitotoxic experimental models in vivo [0.03%]
延迟给予VEGF能够有效拯救兴奋毒损伤脊髓运动神经元且具有时间依赖性效应
Luis B Tovar-y-Romo,Ricardo Tapia
Luis B Tovar-y-Romo
VEGF (vascular endothelial growth factor) prevents neuronal death in different models of ALS (amyotrophic lateral sclerosis), but few studies have addressed the efficacy of VEGF to protect motor neurons after the onset of symptoms, a critic...
Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model [0.03%]
慢性兴奋毒诱导的轴突退行性变在隔室化神经元培养模型中的研究
Katherine A Hosie,Anna E King,Catherine A Blizzard et al.
Katherine A Hosie et al.
Glutamate excitotoxicity is a major pathogenic process implicated in many neurodegenerative conditions, including AD (Alzheimer's disease) and following traumatic brain injury. Occurring predominantly from over-stimulation of ionotropic glu...
Neurological diseases as primary gliopathies: a reassessment of neurocentrism [0.03%]
神经疾病作为主要胶质细胞疾病：重新评估神经 centrism
Alexei Verkhratsky,Michael V Sofroniew,Albee Messing et al.
Alexei Verkhratsky et al.
Diseases of the human brain are almost universally attributed to malfunction or loss of nerve cells. However, a considerable amount of work has, during the last decade, expanded our view on the role of astrocytes in CNS (central nervous sys...
Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route [0.03%]
钙离子作为星形胶质细胞信号传导通路的评估报告
Robert Zorec,Alfonso Araque,Giorgio Carmignoto et al.
Robert Zorec et al.
Astroglial cells, due to their passive electrical properties, were long considered subservient to neurons and to merely provide the framework and metabolic support of the brain. Although astrocytes do play such structural and housekeeping r...
Carlos Matute,Bruce R Ransom
Carlos Matute
The phylogenetic enlargement of cerebral cortex culminating in the human brain imposed greater communication needs that have been met by the massive expansion of WM (white matter). Damage to WM alters brain function, and numerous neurologic...
Astroglial pentose phosphate pathway rates in response to high-glucose environments [0.03%]
高糖环境下星形胶质细胞戊糖磷酸途径的反应速率
Shinichi Takahashi,Yoshikane Izawa,Norihiro Suzuki
Shinichi Takahashi
ROS (reactive oxygen species) play an essential role in the pathophysiology of diabetes, stroke and neurodegenerative disorders. Hyperglycaemia associated with diabetes enhances ROS production and causes oxidative stress in vascular endothe...
Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons [0.03%]
DAMGO对黑质纹状体通路不同区域和不同类型神经元的细胞效应及相关机制研究
Yao-Ying Ma,Carlos Cepeda,Payush Chatta et al.
Yao-Ying Ma et al.
The striatum can be divided into the DLS (dorsolateral striatum) and the VMS (ventromedial striatum), which includes NAcC (nucleus accumbens core) and NAcS (nucleus accumbens shell). Here, we examined differences in electrophysiological pro...