Demystifying The Myelin g Ratio: Its Origin, Derivation and Interpretation [0.03%]
揭秘轴突髓鞘g比率：它的起源、推导和解读
Alexander Gow
Alexander Gow
Most studies involving myelin g ratios over the past 120 years assume this metric enumerates differences in myelin thickness (larger g ratio = thinner myelin) with axon or fiber diameter. And, moreover, such changes are directly correlated ...
Dysregulated Expression of Inflammasome and Extracellular Matrix Genes in C9orf72-ALS/FTD Microglia [0.03%]
C9orf72-ALS/FTD小胶质细胞中炎症小体和基质基因的表达失调
Louise Thiry,Nisha S Pulimood,Ye Man Tang et al.
Louise Thiry et al.
Hexanucleotide repeat expansion (HRE) in the non-coding region of the gene C9orf72 is the most prevalent mutation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The C9orf72 HRE contributes to neuron degeneration i...
Identifying Lanthionine Ketimine Derivatives for Maturation and Proliferative Effects in Oligodendrocyte Progenitor Cells [0.03%]
用于少突胶质前体细胞成熟和增殖的 lanthionine ketimine 衍生物的鉴定
Zachary McDonald,Ankit Tandon,Travis T Denton et al.
Zachary McDonald et al.
Previous studies have shown that lanthionine ketimine ethyl ester (LKE) reduces clinical scores in the experimental autoimmune encephalomyelitis (EAE) mouse model of Multiple Sclerosis, induces differentiation of oligodendrocyte progenitor ...
Cortical Stimulation-Based Transcriptome Shifts on Parkinson's Disease Animal Model [0.03%]
基于皮层电刺激的帕金森病动物模型转录组变化研究
Johyeon Nam,Hongseong Shin,Chaeyeon You et al.
Johyeon Nam et al.
Parkinson's disease is the second most prevalent neurodegenerative disorder and is characterized by the degeneration of dopaminergic neurons. Significant improvements in gait balance, particularly in step length and velocity, were observed ...
Analysis of Oligodendrocyte Lineage Cell Progression with Cre-Mediated RiboTag Reporter Lines [0.03%]
Cre重组酶介导的RiboTag报告系在少突胶质细胞谱系细胞分化中的应用分析研究
George S Melchor,Maya S Shah,Zeeba Manavi et al.
George S Melchor et al.
Cre-reporter strategies in transgenic mice are widely used to assess the specificity of gene promoter activities, and for fate-mapping studies during development and under injury conditions. The ribosome tagging strategy, RiboTag, is a tran...
Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer's Disease [0.03%]
阿尔茨海默病中增殖的小胶质细胞表现出独特的转录和功能变化
Nàdia Villacampa,Heela Sarlus,Paula Martorell et al.
Nàdia Villacampa et al.
Proliferation of microglia represents a physiological process, which is accelerated in several neurodegenerative disorders including Alzheimer disease (AD). The effect of such neurodegeneration-associated microglial proliferation on functio...
Joseph Jr Asante Jr,Steven W Barger
Joseph Jr Asante Jr
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects more than 50 million people worldwide. One of the hallmark features of AD is the accumulation of amyloid β-peptide (Aβ) protein in the brain. P-glycoprotein...
Assessment of Phase-Dependent Alterations in Cortical Glycolytic and Mitochondrial Metabolism Following Ischemic Stroke [0.03%]
缺血性卒中后皮质糖酵解和线粒体代谢相依赖性改变的评估
Shokofeh Rahimpour,Ethan Meadows,John M Hollander et al.
Shokofeh Rahimpour et al.
Maintaining optimal brain metabolism supports neuronal function, synaptic communication, and cognitive processes. During ischemic stroke, brain metabolism and cellular bioenergetics within the neurovascular unit are disrupted, emphasizing t...
R Douglas Fields,Dipankar J Dutta
R Douglas Fields
Advances in Research on Exosomal miRNAs in Central Nervous System Diseases [0.03%]
中枢神经系统疾病中外泌体miRNAs的研究进展
Guangli Feng,Xiaoqian Lan,Shiyi Qin et al.
Guangli Feng et al.
Neurological diseases present a wide range of conditions, intricate diagnosis and treatment processes, and complex prognostic considerations. Therefore, research focusing on the diagnosis and treatment of these diseases is crucial. Exosomal...