Lymphocytes with cytotoxic activity induce rapid microtubule axonal destabilization independently and before signs of neuronal death [0.03%]
细胞毒性淋巴细胞迅速诱导轴突微管去稳定化独立于神经元死亡症状之前发生
Nichole M Miller,Leah P Shriver,Vijaya L Bodiga et al.
Nichole M Miller et al.
MS (multiple sclerosis) is the most prevalent autoimmune disease of the CNS (central nervous system) historically characterized as an inflammatory and demyelinating disease. More recently, extensive neuronal pathology has lead to its classi...
Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun [0.03%]
热休克蛋白70通过增强c-jun的泛素-蛋白酶体途径降解来预防神经营养调节素诱导的脱髓鞘作用
Chengyuan Li,Jiacheng Ma,Huiping Zhao et al.
Chengyuan Li et al.
Modulating molecular chaperones is emerging as an attractive approach to treat neurodegenerative diseases associated with protein aggregation, DPN (diabetic peripheral neuropathy) and possibly, demyelinating neuropathies. KU-32 [N-(7-((2R,3...
Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun [0.03%]
热休克蛋白70通过增强c-jun的泛素-蛋白酶体降解来预防神经调节蛋白诱导的脱髓鞘作用
Chengyuan Li,Jiacheng Ma,Huiping Zhao et al.
Chengyuan Li et al.
Modulating molecular chaperones is emerging as an attractive approach to treat neurodegenerative diseases associated with protein aggregation, DPN (diabetic peripheral neuropathy) and possibly, demyelinating neuropathies. KU-32 [N-(7-((2R,3...
The palmitoylation state of PMP22 modulates epithelial cell morphology and migration [0.03%]
PMP22的棕榈酰化状态可调节上皮细胞形态和迁移能力
Susie J Zoltewicz,Sooyeon Lee,Vinita G Chittoor et al.
Susie J Zoltewicz et al.
PMP22 (peripheral myelin protein 22), also known as GAS 3 (growth-arrest-specific protein 3), is a disease-linked tetraspan glycoprotein of peripheral nerve myelin and constituent of intercellular junctions in epithelia. To date, our knowle...
Analysis of grey matter in thalamus and basal ganglia based on EEG α3/α2 frequency ratio reveals specific changes in subjects with mild cognitive impairment [0.03%]
基于EEGα3/α2频段比值的丘脑和基底节灰质分析发现轻度认知障碍患者特异性改变
Davide V Moretti,Donata Paternicò,Giuliano Binetti et al.
Davide V Moretti et al.
GM (grey matter) changes of thalamus and basal ganglia have been demonstrated to be involved in AD (Alzheimer's disease). Moreover, the increase of a specific EEG (electroencephalogram) marker, α3/α2, have been associated with AD-converte...
Astrogliosis during acute and chronic cuprizone demyelination and implications for remyelination [0.03%]
急性期和慢性期杯rizone脱髓鞘期间的星形胶质细胞增生及其对再髓鞘化的影响
Norah Hibbits,Jun Yoshino,Tuan Q Le et al.
Norah Hibbits et al.
In multiple sclerosis, microglia/macrophage activation and astrocyte reactivity are important components of the lesion environment that can impact remyelination. The current study characterizes these glial populations relative to expression...
Nanoparticle targeting to neurons in a rat hippocampal slice culture model [0.03%]
纳米颗粒在大鼠海马切片培养模型中的神经元靶向作用
Ryan Walters,Richard P Kraig,Igor Medintz et al.
Ryan Walters et al.
We have previously shown that CdSe/ZnS core/shell luminescent semiconductor nanocrystals or QDs (quantum dots) coated with PEG [poly(ethylene glycol)]-appended DHLA (dihydrolipoic acid) can bind AcWG(Pal)VKIKKP(9)GGH(6) (Palm1) through the ...
Dopamine D2 receptor-mediated Akt/PKB signalling: initiation by the D2S receptor and role in quinpirole-induced behavioural activation [0.03%]
多巴胺D2受体介导的Akt/PKB信号转导：D2S受体启动及在喹丙醇致行为活化中的作用
Han-Ting Chen,Nan-Yu Ruan,Jin-Chung Chen et al.
Han-Ting Chen et al.
The short and long isoforms of the dopamine D2 receptor (D2S and D2L respectively) are highly expressed in the striatum. Functional D2 receptors activate an intracellular signalling pathway that includes a cAMP-independent route involving A...
Neuroblast migration and P2Y(1) receptor mediated calcium signalling depend on 9-O-acetyl GD3 ganglioside [0.03%]
神经元迁移和P2Y1受体介导的钙信号依赖于9-O-乙酰基GD3神经节苷脂
Marcelo F Santiago,Eliana Scemes
Marcelo F Santiago
Previous studies indicated that a ganglioside 9acGD3 (9-O-acetyl GD3) antibody [the J-Ab (Jones antibody)] reduces GCP (granule cell progenitor) migration in vitro and in vivo. We here investigated, using cerebellar explants of post-natal d...
Mice lacking the β2 adrenergic receptor have a unique genetic profile before and after focal brain ischaemia [0.03%]
缺乏β2肾上腺素受体的小鼠在局灶性脑缺血前和缺血后的基因表达独特
Robin E White,Curtis Palm,Lijun Xu et al.
Robin E White et al.
The role of the β2AR (β2 adrenergic receptor) after stroke is unclear as pharmacological manipulations of the β2AR have produced contradictory results. We previously showed that mice deficient in the β2AR (β2KO) had smaller infarcts co...