The use of poly(N-[2-hydroxypropyl]-methacrylamide) hydrogel to repair a T10 spinal cord hemisection in rat: a behavioural, electrophysiological and anatomical examination [0.03%]
聚-N-（2-羟丙基）甲基丙烯酰胺水凝胶修复SD大鼠T10脊髓半横断损伤后的行为学、电生理及形态学生物学检测研究
Vincent Pertici,Julien Amendola,Jérôme Laurin et al.
Vincent Pertici et al.
There have been considerable interests in attempting to reverse the deficit because of an SCI (spinal cord injury) by restoring neural pathways through the lesion and by rebuilding the tissue network. In order to provide an appropriate micr...
Brain gangliosides of a transgenic mouse model of Alzheimer's disease with deficiency in GD3-synthase: expression of elevated levels of a cholinergic-specific ganglioside, GT1aα [0.03%]
GD3合成酶缺陷的阿尔茨海默病转基因小鼠脑糖脂体的变化：胆碱能特异性的糖脂体GT1aα水平升高
Toshio Ariga,Yutaka Itokazu,Michael P McDonald et al.
Toshio Ariga et al.
In order to examine the potential involvement of gangliosides in AD (Alzheimer's disease), we compared the ganglioside compositions of the brains of a double-transgenic (Tg) mouse model [APP (amyloid precursor protein)/PSEN1 (presenilin)] o...
Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity [0.03%]
帕金森病中的神经免疫学过程及其与α-突触核蛋白的关系：小胶质细胞作为神经元过程和外周免疫之间的裁判
Vanesa Sanchez-Guajardo,Christopher J Barnum,Malú G Tansey et al.
Vanesa Sanchez-Guajardo et al.
The role of neuroinflammation and the adaptive immune system in PD (Parkinson's disease) has been the subject of intense investigation in recent years, both in animal models of parkinsonism and in post-mortem PD brains. However, how these p...
Increased carbonylation, protein aggregation and apoptosis in the spinal cord of mice with experimental autoimmune encephalomyelitis [0.03%]
实验性自身免疫性脑脊髓炎小鼠脊髓中的羰基化、蛋白聚集和细胞凋亡增加
Anushka Dasgupta,Jianzheng Zheng,Nora I Perrone-Bizzozero et al.
Anushka Dasgupta et al.
Previous work from our laboratory implicated protein carbonylation in the pathophysiology of both MS (multiple sclerosis) and its animal model EAE (experimental autoimmune encephalomyelitis). Subsequent in vitro studies revealed that the ac...
Iron oxide magnetic nanoparticles highlight early involvement of the choroid plexus in central nervous system inflammation [0.03%]
铁氧化磁性纳米颗粒揭示脉络丛在中枢神经系统炎症早期的作用
Jason M Millward,Jörg Schnorr,Matthias Taupitz et al.
Jason M Millward et al.
Neuroinflammation during multiple sclerosis involves immune cell infiltration and disruption of the BBB (blood-brain barrier). Both processes can be visualized by MRI (magnetic resonance imaging), in multiple sclerosis patients and in the a...
GFAP expression as an indicator of disease severity in mouse models of Alexander disease [0.03%]
GFAP表达作为亚历山大病小鼠模型疾病严重程度的指标
Paige L Jany,Tracy L Hagemann,Albee Messing
Paige L Jany
AxD (Alexander disease) is a rare disorder caused by heterozygous mutations in GFAP (glial fibrillary acidic protein) resulting in accumulation of the GFAP protein and elevation of Gfap mRNA. To test whether GFAP itself can serve as a bioma...
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development [0.03%]
mTOR：从细胞外环境到少突胶质细胞发育的转录调节之间的联系
Teresa L Wood,Kathryn K Bercury,Stacey E Cifelli et al.
Teresa L Wood et al.
Oligodendrocyte development is controlled by numerous extracellular signals that regulate a series of transcription factors that promote the differentiation of oligodendrocyte progenitor cells to myelinating cells in the central nervous sys...
Neural and oligodendrocyte progenitor cells: transferrin effects on cell proliferation [0.03%]
神经和少突胶质前体细胞：转铁蛋白对细胞增殖的影响
Lucas Silvestroff,Paula Gabriela Franco,Juana María Pasquini
Lucas Silvestroff
NSC (neural stem cells)/NPC (neural progenitor cells) are multipotent and self-renew throughout adulthood in the SVZ (subventricular zone) of the mammalian CNS (central nervous system). These cells are considered interesting targets for CNS...
Decreased reelin expression and organophosphate pesticide exposure alters mouse behaviour and brain morphology [0.03%]
雷林表达降低及有机磷酸盐农药暴露可改变鼠类行为和脑形态学
Brian R Mullen,Elvira Khialeeva,Daniel B Hoffman et al.
Brian R Mullen et al.
Genetic and environmental factors are both likely to contribute to neurodevelopmental disorders, including ASDs (autism spectrum disorders). In this study, we examined the combinatorial effect of two factors thought to be involved in autism...
Tumour necrosis factor α enhances CCL2 and ICAM-1 expression in peripheral nerve microvascular endoneurial endothelial cells [0.03%]
肿瘤坏死因子α增强外周神经微血管内皮细胞中CCL2和ICAM-1的表达
Kelly A Langert,Cynthia L Von Zee,Evan B Stubbs Jr
Kelly A Langert
Recruitment and trafficking of autoreactive leucocytes across the BNB (blood-nerve barrier) is an early pathological insult in GBS (Guillain-Barré syndrome), an aggressive autoimmune disorder of the PNS (peripheral nervous system). Whereas...