Increased binding of stroke-induced long non-coding RNAs to the transcriptional corepressors Sin3A and coREST [0.03%]
缺血诱导的长链非编码RNA与转录共抑制因子Sin3A和coREST结合增多
Ashutosh Dharap,Courtney Pokrzywa,Raghu Vemuganti
Ashutosh Dharap
LncRNAs (long non-coding RNAs) are thought to play a significant role in cellular homeostasis during development and disease by interacting with CMPs (chromatin-modifying proteins). We recently showed that following transient focal ischemia...
Astrocytes and glutamate homoeostasis in Alzheimer's disease: a decrease in glutamine synthetase, but not in glutamate transporter-1, in the prefrontal cortex [0.03%]
星形胶质细胞和谷氨酸稳态在阿尔茨海默病中的作用：前额叶皮层中谷氨酰胺合成酶而非谷氨酸转运体-1减少
Magdalena Kulijewicz-Nawrot,Eva Syková,Alexander Chvátal et al.
Magdalena Kulijewicz-Nawrot et al.
Astrocytes control tissue equilibrium and hence define the homoeostasis and function of the CNS (central nervous system). Being principal homoeostatic cells, astroglia are fundamental for various forms of neuropathology, including AD (Alzhe...
Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens [0.03%]
药物引发的小鼠可卡因求取行为的恢复：伏隔核中型棘神经元兴奋性增强
Yao-Ying Ma,Sandy M Henley,Jeff Toll et al.
Yao-Ying Ma et al.
To examine the mechanisms of drug relapse, we first established a model for cocaine IVSA (intravenous self-administration) in mice, and subsequently examined electrophysiological alterations of MSNs (medium-sized spiny neurons) in the NAc (...
Neuroendocrine and cardiac metabolic dysfunction and NLRP3 inflammasome activation in adipose tissue and pancreas following chronic spinal cord injury in the mouse [0.03%]
小鼠慢性脊髓损伤后神经内分泌和心脏代谢功能障碍及脂肪组织和胰腺中NLRP3炎性体的激活
Gregory E Bigford,Valerie C Bracchi-Ricard,Robert W Keane et al.
Gregory E Bigford et al.
CVD (cardiovascular disease) represents a leading cause of mortality in chronic SCI (spinal cord injury). Several component risk factors are observed in SCI; however, the underlying mechanisms that contribute to these risks have not been de...
The GluN3A subunit exerts a neuroprotective effect in brain ischemia and the hypoxia process [0.03%]
谷氨酸N-甲基-D-天冬氨酸受体3A亚单位在脑缺血及低氧过程中的神经保护效应
Hui Wang,Haitao Yan,Shuzhuo Zhang et al.
Hui Wang et al.
NMDARs (N-methyl-D-aspartate receptors) mediate the predominantly excitatory neurotransmission in the CNS (central nervous system). Excessive release of glutamate and overactivation of NMDARs during brain ischemia and the hypoxia process ar...
The multifaceted responses of primary human astrocytes and brain microvascular endothelial cells to the Lyme disease spirochete, Borrelia burgdorferi [0.03%]
人源原代少突胶质细胞和脑微血管内皮细胞对莱姆病螺旋体波浪疏螺旋体的多种反应形式
Catherine A Brissette,Eric D Kees,Margaret M Burke et al.
Catherine A Brissette et al.
The vector-borne pathogen, Borrelia burgdorferi, causes a multi-system disorder including neurological complications. These neurological disorders, collectively termed neuroborreliosis, can occur in up to 15% of untreated patients. The neur...
Keiichiro Susuki
Keiichiro Susuki
Dysfunction and/or disruption of nodes of Ranvier are now recognized as key contributors to the pathophysiology of various neurological diseases. One reason is that the excitable nodal axolemma contains a high density of Nav (voltage-gated ...
Inhibition of the group I mGluRs reduces acute brain damage and improves long-term histological outcomes after photothrombosis-induced ischaemia [0.03%]
metabotropic glutamate受体抑制减少光凝血诱导的缺血急性脑损伤并改善长期组织病理学预后
Hailong Li,Nannan Zhang,Grace Sun et al.
Hailong Li et al.
Group I mGluRs (metabotropic glutamate receptors), including mGluR1 and mGluR5, are GPCRs (G-protein coupled receptors) and play important roles in physiology and pathology. Studies on their role in cerebral ischaemia have provided controve...
Egr-1 is a critical regulator of EGF-receptor-mediated expansion of subventricular zone neural stem cells and progenitors during recovery from hypoxia-hypoglycemia [0.03%]
Egr-1是EGF受体介导的缺氧低血糖恢复期侧脑室周围神经干细胞和祖细胞增殖的关键调节因子
Dhivyaa Alagappan,Murugabaskar Balan,Yuhui Jiang et al.
Dhivyaa Alagappan et al.
We recently established that the EGF-R (epidermal growth factor receptor) (EGF-R) is an essential regulator of the reactive expansion of SVZ (subventricular zone) NPs (neural precursors) that occurs during recovery from hypoxic-ischemic bra...
Linde Kegel,Eerik Aunin,Dies Meijer et al.
Linde Kegel et al.
The development and function of the vertebrate nervous system depend on specific interactions between different cell types. Two examples of such interactions are synaptic transmission and myelination. LGI1-4 (leucine-rich glioma inactivated...