Circadian dysfunction in response to in vivo treatment with the mitochondrial toxin 3-nitropropionic acid [0.03%]
3-硝基丙酸这种线粒体毒素的活体治疗反应中的生物钟功能障碍
Takashi Kudo,Dawn H Loh,Yu Tahara et al.
Takashi Kudo et al.
Sleep disorders are common in neurodegenerative diseases including Huntington's disease (HD) and develop early in the disease process. Mitochondrial alterations are believed to play a critical role in the pathophysiology of neurodegenerativ...
Role of glycogenolysis in stimulation of ATP release from cultured mouse astrocytes by transmitters and high K+ concentrations [0.03%]
氨茶碱和高钾离子浓度通过糖原分解促进小胶质细胞释放ATP的作用机制研究
Junnan Xu,Dan Song,Qiufang Bai et al.
Junnan Xu et al.
This study investigates the role of glycogenolysis in stimulated release of ATP as a transmitter from astrocytes. Within the last 20 years our understanding of brain glycogenolysis has changed from it being a relatively uninteresting proces...
Erratum: Drug-primed reinstatement of cocaine seeking in mice: increased excitability of mediumsized spiny neurons in the nucleus accumbens [0.03%]
Cocaine再觅模型中小刺鼠核神经元兴奋性增强英文注释的勘误说明
Yao-Ying Ma,Sandy M Henley,Jeff Toll et al.
Yao-Ying Ma et al.
[This corrects the article on p. e122 in vol. 5.].
Published Erratum
ASN neuro. 2013 Oct 25;5(4):e00122. DOI: 2013
Involvement of the Notch pathway in terminal astrocytic differentiation: role of PKA [0.03%]
PKA在 notch信号途径参与终末星形胶质细胞分化中的作用
Carla Angulo-Rojo,Rebeca Manning-Cela,Adán Aguirre et al.
Carla Angulo-Rojo et al.
The Notch pathway is a highly conserved signaling system essential for modulating neurogenesis and promoting astrogenesis. Similarly, the cAMP signaling cascade can promote astrocytic commitment in several cell culture models, such as the C...
PPAR agonists as therapeutics for CNS trauma and neurological diseases [0.03%]
过氧化物酶体增殖活化受体激动剂作为中枢神经系统损伤和神经退行性疾病治疗药物的潜力
Shweta Mandrekar-Colucci,Andrew Sauerbeck,Phillip G Popovich et al.
Shweta Mandrekar-Colucci et al.
Traumatic injury or disease of the spinal cord and brain elicits multiple cellular and biochemical reactions that together cause or are associated with neuropathology. Specifically, injury or disease elicits acute infiltration and activatio...
Identification of Bax-interacting proteins in oligodendrocyte progenitors during glutamate excitotoxicity and perinatal hypoxia-ischemia [0.03%]
在谷氨酸兴奋毒性及围产期缺氧-缺血期间识别少突前体细胞中与Bax相互作用的蛋白质
Sopio Simonishvili,Mohit Raja Jain,Hong Li et al.
Sopio Simonishvili et al.
OPC (oligodendrocyte progenitor cell) death contributes significantly to the pathology and functional deficits following hypoxic-ischemic injury in the immature brain and to deficits resulting from demyelinating diseases, trauma and degener...
Biochemical characterization of protein quality control mechanisms during disease progression in the C22 mouse model of CMT1A [0.03%]
CMT1A小鼠模型疾病进展过程中蛋白质质量控制机制的生化特征分析
Vinita G Chittoor,Lee Sooyeon,Sunitha Rangaraju et al.
Vinita G Chittoor et al.
Charcot-Marie-Tooth disease type 1A (CMT1A) is a hereditary demyelinating neuropathy linked with duplication of the peripheral myelin protein 22 (PMP22) gene. Transgenic C22 mice, a model of CMT1A, display many features of the human disease...
Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration [0.03%]
色素上皮衍生因子在视网膜退行性变小鼠模型中减少凋亡和促炎症细胞因子基因表达
Yujuan Wang,Preeti Subramanian,Defen Shen et al.
Yujuan Wang et al.
AMD (age-related macular degeneration) is a neurodegenerative disease causing irreversible central blindness in the elderly. Apoptosis and inflammation play important roles in AMD pathogenesis. PEDF (pigment epithelium-derived factor) is a ...
MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis [0.03%]
血脑屏障中的TIMP1在病毒性脑脊髓炎中发挥MMP非依赖性的功能作用
Carine Savarin,Cornelia C Bergmann,David R Hinton et al.
Carine Savarin et al.
Infection of the CNS (central nervous system) with a sublethal neurotropic coronavirus (JHMV) induces a vigorous inflammatory response. CD4⁺ and CD8⁺ T cells are essential to control infectious virus but at the cost of tissue damage. An e...
Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation [0.03%]
半胱天冬酶切割产生GFAP片段促进胶质纤维酸性蛋白丝聚集
Mei-Hsuan Chen,Tracy L Hagemann,Roy A Quinlan et al.
Mei-Hsuan Chen et al.
IF (intermediate filament) proteins can be cleaved by caspases to generate proapoptotic fragments as shown for desmin. These fragments can also cause filament aggregation. The hypothesis is that disease-causing mutations in IF proteins and ...