Charcot-Marie-Tooth disease, psychiatric indicators and quality of life: a systematic review [0.03%]
Charcot-Marie-Tooth疾病、精神症状和生活质量：系统评价研究
Joana L C Cordeiro,Wilson Marques,Jaime E C Hallak et al.
Joana L C Cordeiro et al.
This study is aimed to conduct a systematic literature review regarding the associations between psychiatric symptoms, functional impairments, and quality of life in patients with CMT (Charcot-Marie-Tooth). The PUBMED, PsycInfo, SCIELO, and...
Transcriptional regulation induced by cAMP elevation in mouse Schwann cells [0.03%]
cAMP诱导的鼠雪旺细胞转录调控研究
Daniela Schmid,Thomas Zeis,Nicole Schaeren-Wiemers
Daniela Schmid
In peripheral nerves, Schwann cell development is regulated by a variety of signals. Some of the aspects of Schwann cell differentiation can be reproduced in vitro in response to forskolin, an adenylyl cyclase activator elevating intracellu...
Possible role of GABAergic depolarization in neocortical neurons in generating hyperexcitatory behaviors during emergence from sevoflurane anesthesia in the rat [0.03%]
氨基丁酸能去极化在 rats苏醒过程中产生过度兴奋行为的可能作用机制研究
Byung-Gun Lim,Feng-Yan Shen,Young-Beom Kim et al.
Byung-Gun Lim et al.
Hyperexcitatory behaviors occurring after sevoflurane anesthesia are of serious clinical concern, but the underlying mechanism is unknown. These behaviors may result from the potentiation by sevoflurane of GABAergic depolarization/excitatio...
The Cdk5 inhibitor Roscovitine increases LTP induction in corticostriatal synapses [0.03%]
Cdk5抑制剂Roscovitine能增强皮层纹状体突触的长时程强化诱导能力
Jorge Miranda-Barrientos,Elizabeth Nieto-Mendoza,Elizabeth Hernández-Echeagaray
Jorge Miranda-Barrientos
In corticostriatal synapses, LTD (long-term depression) and LTP (long-term potentiation) are modulated by the activation of DA (dopamine) receptors, with LTD being the most common type of long-term plasticity induced using the standard stim...
Role of energy metabolic deficits and oxidative stress in excitotoxic spinal motor neuron degeneration in vivo [0.03%]
能量代谢障碍和氧化应激在兴奋毒性脊髓运动神经元退变中的作用
Luz Diana Santa-Cruz,Ricardo Tapia
Luz Diana Santa-Cruz
MN (motor neuron) death in amyotrophic lateral sclerosis may be mediated by glutamatergic excitotoxicity. Previously, our group showed that the microdialysis perfusion of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) in the rat ...
Accumulation of amyloid-like Aβ1-42 in AEL (autophagy-endosomal-lysosomal) vesicles: potential implications for plaque biogenesis [0.03%]
淀粉样蛋白状Aβ1-42在AEL(自噬-内吞溶酶体)囊泡中积累：对斑块发生的作用及影响
Daijun Ling,Martha Magallanes,Paul M Salvaterra
Daijun Ling
Abnormal accumulation of Aβ (amyloid β) within AEL (autophagy-endosomal-lysosomal) vesicles is a prominent neuropathological feature of AD (Alzheimer's disease), but the mechanism of accumulation within vesicles is not clear. We express s...
Gas6 enhances axonal ensheathment by MBP+ membranous processes in human DRG/OL promyelinating co-cultures [0.03%]
Gas6通过促进人类DRG / OL半成熟共培养体系中MBP +膜性结构进程的方式增强轴突的包绕现象
Kathleen N O&#x;Guin,Ross C Gruber,Cedric S Raine et al.
Kathleen N O&#x;Guin et al.
The molecular requirements for human myelination are incompletely defined, and further study is needed to fully understand the cellular mechanisms involved during development and in demyelinating diseases. We have established a human co-cul...
Kelsey J Weigel,Sharon G Lynch,Steven M LeVine
Kelsey J Weigel
Histochemical and MRI studies have demonstrated that MS (multiple sclerosis) patients have abnormal deposition of iron in both gray and white matter structures. Data is emerging indicating that this iron could partake in pathogenesis by var...
PDGF-responsive progenitors persist in the subventricular zone across the lifespan [0.03%]
整个生命周期中寿命神经干细胞龛中的PDGF反应性前体细胞持续存在
Lisamarie Moore,Jennifer M Bain,Ji Meng Loh et al.
Lisamarie Moore et al.
The SVZ (subventricular zone) contains neural stem cells and progenitors of various potentialities. Although initially parsed into A, B, and C cells, this germinal zone is comprised of a significantly more diverse population of cells. Here,...
ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro [0.03%]
ApoE4延缓神经元发育过程中的树突棘形成并加速体外成熟树突棘的丢失
Evelyn Nwabuisi-Heath,G William Rebeck,Mary Jo Ladu et al.
Evelyn Nwabuisi-Heath et al.
The ε4 allele of the gene that encodes apolipoprotein E (APOE4) is the greatest genetic risk factor for Alzheimer's disease (AD), while APOE2 reduces AD risk, compared to APOE3. The mechanism(s) underlying the effects of APOE on AD patholo...