Cerebral protein synthesis in a knockin mouse model of the fragile X premutation [0.03%]
脆性X染色体前突变敲入小鼠模型中的脑蛋白合成
Mei Qin,Tianjian Huang,Zhonghua Liu et al.
Mei Qin et al.
The (CGG)n-repeat in the 5'-untranslated region of the fragile X mental retardation gene (FMR1) gene is polymorphic and may become unstable on transmission to the next generation. In fragile X syndrome, CGG repeat lengths exceed 200, result...
Hilary H Sachs,Kathryn K Bercury,Daniela C Popescu et al.
Hilary H Sachs et al.
In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain. One model used to underst...
Comparison of cortical and white matter traumatic brain injury models reveals differential effects in the subventricular zone and divergent Sonic hedgehog signaling pathways in neuroblasts and oligodendrocyte progenitors [0.03%]
皮层和白质创伤性脑损伤模型的比较揭示了侧脑室区的差异效应以及神经干细胞和少突胶质细胞祖细胞中Sonic刺猬信号通路的分歧路径
Amanda J Mierzwa,Genevieve M Sullivan,Laurel A Beer et al.
Amanda J Mierzwa et al.
The regenerative capacity of the central nervous system must be optimized to promote repair following traumatic brain injury (TBI) and may differ with the site and form of damage. Sonic hedgehog (Shh) maintains neural stem cells and promote...
Comparative Study
ASN neuro. 2014 Sep 23;6(5):1759091414551782. DOI:10.1177/1759091414551782 2014
Roles and regulation of ketogenesis in cultured astroglia and neurons under hypoxia and hypoglycemia [0.03%]
培养的星形胶质细胞和神经元在缺氧和低血糖条件下的酮体生成作用及调控机制研究
Shinichi Takahashi,Takuya Iizumi,Kyoko Mashima et al.
Shinichi Takahashi et al.
Exogenous ketone bodies (KBs), acetoacetate (AA), and β-hydroxybutyrate (BHB) act as alternative energy substrates in neural cells under starvation. The present study examined the endogenous ketogenic capacity of astroglia under hypoxia wi...
MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells [0.03%]
MAL过表达导致影响细胞骨架组织和施万细胞分化的基因的表达失调
Daniela Schmid,Thomas Zeis,Monia Sobrio et al.
Daniela Schmid et al.
In the developing peripheral nervous system, a coordinated reciprocal signaling between Schwann cells and axons is crucial for accurate myelination. The myelin and lymphocyte protein MAL is a component of lipid rafts that is important for t...
Functions of FUS/TLS from DNA repair to stress response: implications for ALS [0.03%]
从DNA修复到应激反应的FUS/TLS功能：对ALS的意义
Reddy Ranjith Kumar Sama,Catherine L Ward,Daryl A Bosco
Reddy Ranjith Kumar Sama
Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is a multifunctional DNA-/RNA-binding protein that is involved in a variety of cellular functions including transcription, protein translation, RNA splicing, and transport. FUS w...
Induction of oligodendrocyte differentiation and in vitro myelination by inhibition of rho-associated kinase [0.03%]
通过抑制Rho相关激酶诱导少突胶质细胞分化和体外髓鞘形成
Carlos E Pedraza,Christopher Taylor,Albertina Pereira et al.
Carlos E Pedraza et al.
In inflammatory demyelinating diseases such as multiple sclerosis (MS), myelin degradation results in loss of axonal function and eventual axonal degeneration. Differentiation of resident oligodendrocyte precursor cells (OPCs) leading to re...
Cell-type-specific Jumonji histone demethylase gene expression in the healthy rat CNS: detection by a novel flow cytometry method [0.03%]
一种新型流式细胞仪方法检测健康大鼠中枢神经系统中Jumonji组蛋白去甲基化酶的基因表达及其细胞类型特异性
Stephanie M C Smith,Rebecca S Kimyon,Jyoti J Watters
Stephanie M C Smith
Our understanding of how histone demethylation contributes to the regulation of basal gene expression in the brain is largely unknown in any injury model, and especially in the healthy adult brain. Although Jumonji genes are often regulated...
Proinflammatory-activated glioma cells induce a switch in microglial polarization and activation status, from a predominant M2b phenotype to a mixture of M1 and M2a/B polarized cells [0.03%]
促炎症活化的胶质母细胞诱导小胶质细胞极化和激活状态发生转换，从主要的M2b表型转为M1及混合的M2a / b表型
Lucia Lisi,Egidio Stigliano,Libero Lauriola et al.
Lucia Lisi et al.
Malignant gliomas are primary brain tumors characterized by morphological and genetic complexities, as well as diffuse infiltration into normal brain parenchyma. Within gliomas, microglia/macrophages represent the largest tumor-infiltrating...
Temporal patterns of cortical proliferation of glial cell populations after traumatic brain injury in mice [0.03%]
小鼠创伤性脑损伤后胶质细胞群皮层增殖的时程规律研究
Bala T S Susarla,Sonia Villapol,Jae-Hyuk Yi et al.
Bala T S Susarla et al.
TBI (traumatic brain injury) triggers an inflammatory cascade, gliosis and cell proliferation following cell death in the pericontusional area and surrounding the site of injury. In order to better understand the proliferative response foll...