Sarah Berth,Hector Hugo Caicedo,Tulika Sarma et al.
Sarah Berth et al.
The HIV glycoprotein gp120, a neurotoxic HIV glycoprotein that is overproduced and shed by HIV-infected macrophages, is associated with neurological complications of HIV such as distal sensory polyneuropathy, but interactions of gp120 in th...
Brain-derived neurotrophic factor deficiency restricts proliferation of oligodendrocyte progenitors following cuprizone-induced demyelination [0.03%]
脑源性神经营养因子缺乏限制了杯rizone诱导的脱髓鞘后的少突胶质前体细胞增殖
Vladislav Tsiperson,Yangyang Huang,Issa Bagayogo et al.
Vladislav Tsiperson et al.
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that through its neurotrophic tyrosine kinase, receptor, type 2 (TrkB) receptor, increases 5-bromo-2-deoxyuridine incorporation in oligodendro...
Lynda Erskine,Eloisa Herrera
Lynda Erskine
The visual system is beautifully crafted to transmit information of the external world to visual processing and cognitive centers in the brain. For visual information to be relayed to the brain, a series of axon pathfinding events must take...
Hypothermia modulates cytokine responses after neonatal rat hypoxic-ischemic injury and reduces brain damage [0.03%]
亚低温调节新生儿缺氧缺血损伤后的细胞因子反应并减少脑损害
Xiangpeng Yuan,Nirmalya Ghosh,Brian McFadden et al.
Xiangpeng Yuan et al.
While hypothermia (HT) is the standard-of-care for neonates with hypoxic ischemic injury (HII), the mechanisms underlying its neuroprotective effect are poorly understood. We examined ischemic core/penumbra and cytokine/chemokine evolution ...
Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor [0.03%]
人神经干细胞中溶血磷脂酸、鞘氨醇-1-磷酸和LIF对Erk和Akt激酶及神经元分化的并行调节作用：LPA1受体的特异性作用
Phillip Callihan,Mourad W Ali,Hector Salazar et al.
Phillip Callihan et al.
The bioactive lysophospholipids lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have diverse effects on the developing nervous system and neural progenitors, but the molecular basis for their pleiotropic effects is poorly unde...
Both creatine and its product phosphocreatine reduce oxidative stress and afford neuroprotection in an in vitro Parkinson's model [0.03%]
créatine及其产物磷Creatine通过减少氧化应激在帕金森病的体外模型中发挥神经保护作用
Mauricio Peña Cunha,Maria D Martín-de-Saavedra,Alejandro Romero et al.
Mauricio Peña Cunha et al.
Creatine is the substrate for creatine kinase in the synthesis of phosphocreatine (PCr). This energetic system is endowed of antioxidant and neuroprotective properties and plays a pivotal role in brain energy homeostasis. The purpose of thi...
Pre- and posttreatment with edaravone protects CA1 hippocampus and enhances neurogenesis in the subgranular zone of dentate gyrus after transient global cerebral ischemia in rats [0.03%]
edaravone治疗前后保护暂时性全脑缺血大鼠CA1区和海马齿状回颗粒下层神经发生的作用及机制研究
Shan Lei,Pengbo Zhang,Weisong Li et al.
Shan Lei et al.
Edaravone is clinically used for treatment of patients with acute cerebral infarction. However, the effect of double application of edaravone on neurogenesis in the hippocampus following ischemia remains unknown. In the present study, we ex...
Dietary Sutherlandia and elderberry mitigate cerebral ischemia-induced neuronal damage and attenuate p47phox and phospho-ERK1/2 expression in microglial cells [0.03%]
辣木和矢车菊饮食可减轻脑缺血引起的神经元损伤并减弱微胶质细胞中p47phox和磷酸化ERK1/2的表达
Dennis Y Chuang,Jiankun Cui,Agnes Simonyi et al.
Dennis Y Chuang et al.
Sutherlandia (Sutherlandia frutescens) and elderberry (Sambucus spp.) are used to promote health and for treatment of a number of ailments. Although studies with cultured cells have demonstrated antioxidative and anti-inflammatory propertie...
Role of the intracellular nucleoside transporter ENT3 in transmitter and high K+ stimulation of astrocytic ATP release investigated using siRNA against ENT3 [0.03%]
使用ENT3的siRNA研究胞内核苷转运体ENT3在神经递质和高钾刺激星形胶质细胞ATP释放中的作用
Dan Song,Junnan Xu,Qiufang Bai et al.
Dan Song et al.
This study investigates the role of the intracellular adenosine transporter equilibrative nucleoside transporter 3 (ENT3) in stimulated release of the gliotransmitter adenosine triphosphate (ATP) from astrocytes. Within the past 20 years, o...
p75NTR, but not proNGF, is upregulated following status epilepticus in mice [0.03%]
小鼠癫痫持续状态后p75NTR表达上调，而不伴发proNGF的上调表达
Melissa W VonDran,John LaFrancois,Victoria A Padow et al.
Melissa W VonDran et al.
ProNGF and p75(NTR) are upregulated and induce cell death following status epilepticus (SE) in rats. However, less is known about the proneurotrophin response to SE in mice, a more genetically tractable species where mechanisms can be more ...