Forced Exercise Preconditioning Attenuates Experimental Autoimmune Neuritis by Altering Th1 Lymphocyte Composition and Egress [0.03%]
强制运动预处理通过改变Th1淋巴细胞组成和流出而减弱实验性自身免疫神经炎
Michael W Calik,Sahadev A Shankarappa,Kelly A Langert et al.
Michael W Calik et al.
A short-term exposure to moderately intense physical exercise affords a novel measure of protection against autoimmune-mediated peripheral nerve injury. Here, we investigated the mechanism by which forced exercise attenuates the development...
Epigenetic Modulation of Microglial Inflammatory Gene Loci in Helminth-Induced Immune Suppression: Implications for Immune Regulation in Neurocysticercosis [0.03%]
寄生虫诱导的免疫抑制中表观遗传调控小胶质细胞炎症基因座位的意义：神经囊尾蚴病中免疫调节的含义
Arun Chauhan,Fredice Z Quenum,Ata Abbas et al.
Arun Chauhan et al.
In neurocysticercosis, parasite-induced immune suppressive effects are thought to play an important role in enabling site-specific inhibition of inflammatory responses to infections. It is axiomatic that microglia-mediated (M1 proinflammato...
Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression [0.03%]
联合降低HDAC1和HDAC2在损伤后通过减少p53靶基因表达促进视网膜神经节细胞的存活
Frédéric Lebrun-Julien,Ueli Suter
Frédéric Lebrun-Julien
Histones deacetylases (HDACs), besides their function as epigenetic regulators, deacetylate and critically regulate the activity of nonhistone targets. In particular, HDACs control partially the proapoptotic activity of p53 by balancing its...
Ionizing Radiation Perturbs Cell Cycle Progression of Neural Precursors in the Subventricular Zone Without Affecting Their Long-Term Self-Renewal [0.03%]
电离辐射扰动神经前体细胞的细胞周期进程，但不影响其长期自我更新能力
Hongxin Chen,Matthew T Goodus,Sonia M de Toledo et al.
Hongxin Chen et al.
Damage to normal human brain cells from exposure to ionizing radiation may occur during the course of radiotherapy or from accidental exposure. Delayed effects may complicate the immediate effects resulting in neurodegeneration and cognitiv...
Semaphorin4A Is Cytotoxic to Oligodendrocytes and Is Elevated in Microglia and Multiple Sclerosis [0.03%]
半数默林蛋白4A对少突胶质细胞有细胞毒作用，并且在小胶质细胞和多发性硬化症中升高
Dominique F Leitner,Bozho Todorich,Xuesheng Zhang et al.
Dominique F Leitner et al.
We have previously established that T cell immunoglobulin and mucin domain containing 2 (Tim2) is an H-ferritin receptor on oligodendrocytes (OLs). Tim2 also binds Semaphorin4A (Sema4A). Sema4A is expressed by lymphocytes, and its role in i...
ROS produced by NOX2 control in vitro development of cerebellar granule neurons development [0.03%]
NOX2产生的ROS对颗粒神经元的发育有促进作用
Mauricio Olguín-Albuerne,Julio Morán
Mauricio Olguín-Albuerne
Reactive oxygen species (ROS) act as signaling molecules that regulate nervous system physiology. ROS have been related to neural differentiation, neuritogenesis, and programmed cell death. Nevertheless, little is known about the mechanisms...
Prostaglandin E2 EP2 receptor deletion attenuates intracerebral hemorrhage-induced brain injury and improves functional recovery [0.03%]
前列腺素E2 EP2受体缺失可减轻脑出血引起的脑损伤并改善功能恢复
Jenna L Leclerc,Andrew S Lampert,Matthew A Diller et al.
Jenna L Leclerc et al.
Intracerebral hemorrhage (ICH) is a devastating type of stroke characterized by bleeding into the brain parenchyma and secondary brain injury resulting from strong neuroinflammatory responses to blood components. Production of prostaglandin...
Low-dose sevoflurane promotes hippocampal neurogenesis and facilitates the development of dentate gyrus-dependent learning in neonatal rats [0.03%]
低浓度的异氟醚能促进新生大鼠海马齿状区神经发生及与年龄相关的空间学习能力的发展
Chong Chen,Feng-Yan Shen,Xuan Zhao et al.
Chong Chen et al.
Huge body of evidences demonstrated that volatile anesthetics affect the hippocampal neurogenesis and neurocognitive functions, and most of them showed impairment at anesthetic dose. Here, we investigated the effect of low dose (1.8%) sevof...
AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system [0.03%]
腺相关病毒介导的基因递送在沙冬氏病猫模型中纠正中枢神经系统溶酶体贮积病变
Hannah E Rockwell,Victoria J McCurdy,Samuel C Eaton et al.
Hannah E Rockwell et al.
Sandhoff disease (SD) is an autosomal recessive neurodegenerative disease caused by a mutation in the gene for the β-subunit of β-N-acetylhexosaminidase (Hex), resulting in the inability to catabolize ganglioside GM2 within the lysosomes....
Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons [0.03%]
内皮素-1和缓激肽激活的afferent感觉神经元中储钙依赖性钙离子进入的差异性研究
Kalina Szteyn,Ruben Gomez,Kelly A Berg et al.
Kalina Szteyn et al.
Endothelin-1 (ET-1) and bradykinin (BK) are endogenous peptides that signal through Gαq/11-protein coupled receptors (GPCRs) to produce nociceptor sensitization and pain. Both peptides activate phospholipase C to stimulate Ca(2+) accumulat...