Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain [0.03%]
小鼠脑中星形胶质细胞水通道激活性调节蛋白-4的表达
Jacqueline A Hubbard,Mike S Hsu,Marcus M Seldin et al.
Jacqueline A Hubbard et al.
Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the central nervous system. Expression is particularly high around areas in contact with cerebrospinal fluid, suggesting that AQP4 plays a role in fl...
Osmotic Edema Rapidly Increases Neuronal Excitability Through Activation of NMDA Receptor-Dependent Slow Inward Currents in Juvenile and Adult Hippocampus [0.03%]
渗透性脑水肿通过激活NMDA受体依赖性的慢速内向电流快速增加青少年和成年海马神经元的兴奋性
Kelli Lauderdale,Thomas Murphy,Tina Tung et al.
Kelli Lauderdale et al.
Cellular edema (cell swelling) is a principal component of numerous brain disorders including ischemia, cortical spreading depression, hyponatremia, and epilepsy. Cellular edema increases seizure-like activity in vitro and in vivo, largely ...
Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion [0.03%]
脑缺血再灌注过程中MAPK/ERK信号通路与PI3K/AKT信号通路的串扰研究
Jing Zhou,Ting Du,Baoman Li et al.
Jing Zhou et al.
The epidermal growth factor receptor (EGFR) is linked to the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and Raf/mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK1/2) signaling pathways. Duri...
Gabriela B Suarez-Mier,Marion S Buckwalter
Gabriela B Suarez-Mier
Autonomic nerves regulate important functions in visceral organs, including the lung. The postganglionic portion of these nerves is ensheathed by glial cells known as non-myelinating Schwann cells. In the brain, glia play important function...
Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice [0.03%]
鼻内递送阿佩林-13可保护缺血性卒中后的小鼠神经并促进其血管生成
Dongdong Chen,Jinhwan Lee,Xiaohuan Gu et al.
Dongdong Chen et al.
Apelin is a peptide originally isolated from bovine stomach tissue extracts and identified as an endogenous ligand of the APJ receptor; recent work showed that apelin ameliorates the ischemic injury in the heart and the brain. Being an anal...
Axo-Glia Interaction Preceding CNS Myelination Is Regulated by Bidirectional Eph-Ephrin Signaling [0.03%]
双向Eph-Ephrin信号调节中枢神经系统髓鞘形成前的神经胶质相互作用
Cecilie Linneberg,Mette Harboe,Lisbeth S Laursen
Cecilie Linneberg
In the central nervous system, myelination of axons is required to ensure fast saltatory conduction and for survival of neurons. However, not all axons are myelinated, and the molecular mechanisms involved in guiding the oligodendrocyte pro...
Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro [0.03%]
神经肽Y受体的激活调节视网膜节细胞电生理并发挥体外神经保护作用
João Martins,Filipe Elvas,Dan Brudzewsky et al.
João Martins et al.
Neuropeptide Y (NPY) is expressed in mammalian retina but the location and potential modulatory effects of NPY receptor activation remain largely unknown. Retinal ganglion cell (RGC) death is a hallmark of several retinal degenerative disea...
SORT1 Mutation Resulting in Sortilin Deficiency and p75(NTR) Upregulation in a Family With Essential Tremor [0.03%]
SORT1突变导致分选蛋白缺陷和p75神经营养素受体上调的家族性特发性震颤
Elena Sánchez,Alberto Bergareche,Catharine E Krebs et al.
Elena Sánchez et al.
*These authors contributed equally to this work.Essential tremor (ET) is the most prevalent movement disorder affecting millions of people in the United States. Although a positive family history is one of the most important risk factors fo...
Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules is Regulated by Electrochemical Oxidation Potential [0.03%]
基于氢醌的亲电子小分子通过电化学氧化势调节NF-E2及相关因子2和热量休眠因子-1通路激活作用
Takumi Satoh,Romain Stalder,Scott R McKercher et al.
Takumi Satoh et al.
Activation of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 and heat-shock protein 90/heat-shock factor-1 signal-transduction pathways plays a central role in combatting cellular oxidative damage and re...
Ryan Walters,Igor L Medintz,James B Delehanty et al.
Ryan Walters et al.
Despite our extensive knowledge of the structure of negatively charged cell surface proteoglycans and sialoglycoconjugates in the brain, we have little understanding of how their negative charge contributes to brain function. We have previo...