Loss of Thy1 in Cortico-Striatal Pathways Alters Response to Dopamine and Gabapentin [0.03%]
纹状体通路中Thy1的丢失影响多巴胺和加巴喷丁的作用响应
Cezar Goletiani,Matthew D McEchron,Elizabeth Neely et al.
Cezar Goletiani et al.
Thy1, a synaptic protein, may support synaptic junction adherence. Thus, we hypothesized that loss of Thy1 may alter synaptic transmission. Our focus on the Thy1 knockout (KO) mouse model stems from the loss of Thy1 expression in individual...
Alexander Gow
Alexander Gow
In contemporary myelin biology, there is a growing trend to prioritize faster, more convenient methodologies for evaluating white matter structure over quality of the analysis. This shift is often accompanied by less attention to the mechan...
MyeliMetric: A Python-Based Toolbox for Standardized G-Ratio Analysis of Axon-Myelin Integrity [0.03%]
MyeliMetric：一种基于Python的工具箱，用于标准化G比值分析轴突髓鞘完整性
Intakhar Ahmad,Farjana Sultana Chowdhury,Anne I Boullerne et al.
Intakhar Ahmad et al.
The g-ratio, defined as the ratio of an axon's diameter to the total fiber diameter (axon plus myelin), is a key metric for assessing myelin integrity and axonal conduction velocity in both the central and peripheral nervous systems. Deviat...
Glutamate-Dependent Dynamic DNA Methylation Regulates Excitatory Amino Acid Transporters in Bergmann Glia Cells: Role of AMPA Receptors [0.03%]
谷氨酸依赖的动态DNA甲基化调节Bergmann胶质细胞中的兴奋性氨基酸转运蛋白：AMPA受体的作用
Bolaji O Oyetayo,Temitayo Subair,Natalia Morales-Ramírez et al.
Bolaji O Oyetayo et al.
Glial glutamate uptake through sodium-dependent excitatory amino acid transporters (EAATs) is essential for synaptic homeostasis. Epigenetic modifications and neurotransmitter receptor signaling influence glial function although their inter...
Crocetin as a Neuroprotective Agent: Targeting Western Diet-Induced Cognitive Dysfunction Through Antioxidant, Anti-Inflammatory and Gut-Brain Axis Modulation [0.03%]
作为神经保护剂的番茄红素：通过抗氧化、抗炎和调节肠-脑轴作用对抗西方饮食引起的认知障碍
Suresh Babu Kondaveeti,Vrinda Gupta,Aaqib Ahmad Dar et al.
Suresh Babu Kondaveeti et al.
Western diet-induced cognitive dysfunction is a rapidly emerging health challenge driven by excessive intake of high-fat, high-sugar, and ultra-processed foods. These dietary patterns promote neuroinflammation, oxidative stress, insulin res...
Oliver Schmitt,Hannes Kaddatz,Stefan Mikkat et al.
Oliver Schmitt et al.
The myelin proteome is a critical structural and functional component of the central nervous system (CNS), undergoing dynamic remodeling throughout life. Pathological changes, such as those in multiple sclerosis, disrupt myelin integrity an...
The CEMIP Hyaluronidase is Elevated in Oligodendrocyte Progenitor Cells and Inhibits Oligodendrocyte Maturation [0.03%]
CEMIP 胶尿酸酶在少突胶质前体细胞中高表达并抑制少突胶质细胞的成熟
Alec Peters,Kanon Yasuhara,Weiping Su et al.
Alec Peters et al.
Central nervous system (CNS) demyelination occurs in numerous conditions including multiple sclerosis (MS). CNS remyelination involves recruitment and maturation of oligodendrocyte progenitor cells (OPCs). Remyelination often fails in part ...
Global Deficiency of Alzheimer's Disease Risk Gene Il1rap Reduces Pathological Tau in a Mouse Model of Systemic Inflammation [0.03%]
载脂蛋白ε4等位基因阴性的小鼠tau病理学的系统性炎症反应机制研究
Somayeh Dadras,Kiran Bhaskar
Somayeh Dadras
Brain inflammation is strongly associated with neurodegeneration in Alzheimer's disease (AD) and related tauopathies. We have previously demonstrated that microglia-derived interleukin-1β (IL-1β) induces tau hyperphosphorylation in a cell...
Dual Stages of Alcohol-Related Cerebral White Matter Degeneration Reviewed: Early-Stage Stress/Neuroinflammation Versus Late-Stage Impaired Insulin/IGF Signaling Through Akt-mTOR-Review [0.03%]
酒精相关脑白质退行性变的双阶段：早期应激/神经炎症与晚期胰岛素/IGF信号缺陷通过Akt-mTOR-综述
Suzanne M de la Monte,Greg Sutherland
Suzanne M de la Monte
Long-term effects of alcohol-related brain damage (ARBD) include neurocognitive and neurobehavioral dysfunctions with neurodegeneration. White matter (WM) is notably targeted across the lifespan yet relatively little is known about the stag...
Combined Treatment with Minocycline and an mGluR5 Antagonist Alters Resting EEG Spectral Power, but Not Sound-Evoked Responses, in a Mouse Model of Fragile X Syndrome [0.03%]
二氢麦角碱与mGluR5拮抗剂联合治疗改变脆弱X染色体综合征小鼠模型静息EEG谱功率，但不影响声音诱发反应
M H Kassir,J W Lovelace,D K Binder et al.
M H Kassir et al.
Fragile X Syndrome (FXS) is a leading genetic cause of intellectual disability and autism-like behaviors. Glutamatergic mGluR5 receptors and matrix metalloproteinase-9 (MMP-9) are therapeutic targets to treat FXS, but clinical trials target...