Large-Scale Functional RNAi Screen in C. elegans Identifies TGF-β and Notch Signaling Pathways as Modifiers of CACNA1A [0.03%]
大规模的功能性RNAi筛选鉴定出TGF-β和Notch信号通路作为CACNA1A的调节因子
Maria da Conceição Pereira,Sara Morais,Jorge Sequeiros et al.
Maria da Conceição Pereira et al.
Variants in CACNA1A that encodes the pore-forming α1-subunit of human voltage-gated Cav2.1 (P/Q-type) Ca(2+)channels cause several autosomal-dominant neurologic disorders, including familial hemiplegic migraine type 1, episodic ataxia type...
Refined Analysis of Brain Energy Metabolism Using In Vivo Dynamic Enrichment of 13C Multiplets [0.03%]
利用体内动态富集的13C多峰进行脑能量代谢的精确诊断
Masoumeh Dehghani M,Bernard Lanz,João M N Duarte et al.
Masoumeh Dehghani M et al.
Carbon-13 nuclear magnetic resonance spectroscopy in combination with the infusion of (13)C-labeled precursors is a unique approach to study in vivo brain energy metabolism. Incorporating the maximum information available from in vivo local...
Astrocytic Ephrin-B1 Regulates Synapse Remodeling Following Traumatic Brain Injury [0.03%]
胶质细胞Ephrin-B1调节创伤性脑损伤后的突触重塑
Angeliki M Nikolakopoulou,Jordan Koeppen,Michael Garcia et al.
Angeliki M Nikolakopoulou et al.
Traumatic brain injury (TBI) can result in tissue alterations distant from the site of the initial injury, which can trigger pathological changes within hippocampal circuits and are thought to contribute to long-term cognitive and neuropsyc...
Ganglioside-Dependent Neural Stem Cell Proliferation in Alzheimer's Disease Model Mice [0.03%]
阿尔茨海默病模型小鼠神经干细胞增殖依赖神经节苷脂的特性
Noah A Koon,Yutaka Itokazu,Robert K Yu
Noah A Koon
The aggregation and formation of amyloid plaques by amyloid β-peptides (Aβs) is believed to be one of the pathological hallmarks of Alzheimer's disease (AD). Intriguingly, Aβs have also been shown to possess proliferative effects on neur...
Administration of DHA Reduces Endoplasmic Reticulum Stress-Associated Inflammation and Alters Microglial or Macrophage Activation in Traumatic Brain Injury [0.03%]
DHA通过减少内质网应激介导的炎症和改变小胶质细胞/巨噬细胞活化状态从而促进创伤性脑损伤后的功能恢复
Lloyd D Harvey,Yan Yin,Insiya Y Attarwala et al.
Lloyd D Harvey et al.
We investigated the effects of the administration of docosahexaenoic acid (DHA) post-traumatic brain injury (TBI) on reducing neuroinflammation. TBI was induced by cortical contusion injury in Sprague Dawley rats. Either DHA (16 mg/kg in di...
A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System xc- Mediates Aglycemic Neuronal Cell Death [0.03%]
能量耗竭和系统Xc-释放谷氨酸的细胞毒及协同作用介导无糖神经元细胞死亡
Trista L Thorn,Yan He,Nicole A Jackman et al.
Trista L Thorn et al.
The astrocyte cystine/glutamate antiporter (system xc(-)) contributes substantially to the excitotoxic neuronal cell death facilitated by glucose deprivation. The purpose of this study was to determine the mechanism by which this occurred. ...
The Circadian Clock Gene Period1 Connects the Molecular Clock to Neural Activity in the Suprachiasmatic Nucleus [0.03%]
周期基因Period1连接分子钟与视交叉上核中的神经活动
Takashi Kudo,Gene D Block,Christopher S Colwell
Takashi Kudo
The neural activity patterns of suprachiasmatic nucleus (SCN) neurons are dynamically regulated throughout the circadian cycle with highest levels of spontaneous action potentials during the day. These rhythms in electrical activity are cri...
Ultrastructural Correlates of Enhanced Norepinephrine and Neuropeptide Y Cotransmission in the Spontaneously Hypertensive Rat Brain [0.03%]
自发性高血压脑中去甲肾上腺素和神经肽Y共传递的超微结构相关因素
Ioannis Kourtesis,Sergey Kasparov,Paul Verkade et al.
Ioannis Kourtesis et al.
The spontaneously hypertensive rat (SHR) replicates many clinically relevant features of human essential hypertension and also exhibits behavioral symptoms of attention-deficit/hyperactivity disorder and dementia. The SHR phenotype is highl...
Comparative Study
ASN neuro. 2015 Oct 29;7(5):1759091415610115. DOI:10.1177/1759091415610115 2015
Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina [0.03%]
fractalkine信号通路的破坏导致糖尿病视网膜病变中微胶质细胞活化和神经元损伤
Sandra M Cardona,Andrew S Mendiola,Ya-Chin Yang et al.
Sandra M Cardona et al.
Fractalkine (CX3CL1 or FKN) is a membrane-bound chemokine expressed on neuronal membranes and is proteolytically cleaved to shed a soluble chemoattractant domain. FKN signals via its unique receptor CX3CR1 expressed on microglia and other p...
A Distinct Class of Antibodies May Be an Indicator of Gray Matter Autoimmunity in Early and Established Relapsing Remitting Multiple Sclerosis Patients [0.03%]
一类独特的抗体可能是早期和晚期复发缓解型多发性硬化症患者灰质自身免疫的标志物
Ann J Ligocki,Jacqueline R Rivas,William H Rounds et al.
Ann J Ligocki et al.
*These authors contributed equally to the work in this manuscript.We have previously identified a distinct class of antibodies expressed by B cells in the cerebrospinal fluid (CSF) of early and established relapsing remitting multiple scler...