Knockdown of Unconventional Myosin ID Expression Induced Morphological Change in Oligodendrocytes [0.03%]
非典型肌球蛋白ID敲低诱导少突胶质细胞形态变化
Reiji Yamazaki,Tomoko Ishibashi,Hiroko Baba et al.
Reiji Yamazaki et al.
Myelin is a special multilamellar structure involved in various functions in the nervous system. In the central nervous system, the oligodendrocyte (OL) produces myelin and has a unique morphology. OLs have a dynamic membrane sorting system...
Gas6 Promotes Oligodendrogenesis and Myelination in the Adult Central Nervous System and After Lysolecithin-Induced Demyelination [0.03%]
Gas6促进成人中枢神经系统和溶血磷脂酰胆碱诱导的脱髓鞘后的少突胶质细胞生成及髓鞘形成
Salman Goudarzi,Andrea Rivera,Arthur M Butt et al.
Salman Goudarzi et al.
A key aim of therapy for multiple sclerosis (MS) is to promote the regeneration of oligodendrocytes and remyelination in the central nervous system (CNS). The present study provides evidence that the vitamin K-dependent protein growth arres...
Diffusible Factors Secreted by Glioblastoma and Medulloblastoma Cells Induce Oxidative Stress in Bystander Neural Stem Progenitors [0.03%]
胶质母细胞瘤和髓母细胞瘤细胞分泌的可扩散因子引起旁观者神经干细胞前体的氧化应激反应
Neha Sharma,Nicholas W Colangelo,Sonia M de Toledo et al.
Neha Sharma et al.
Harmful effects that alter the homeostasis of neural stem or progenitor cells (NSPs) can affect regenerative processes in the central nervous system. We investigated the effect of soluble factors secreted by control or (137)Cs-γ-irradiated...
Increased Risk of Autism Development in Children Whose Mothers Experienced Birth Complications or Received Labor and Delivery Drugs [0.03%]
母亲生产时出现并发症或使用分娩药物会增加孩子患自闭症的风险
Melissa Smallwood,Ashley Sareen,Emma Baker et al.
Melissa Smallwood et al.
Autism spectrum disorder (ASD) is a perplexing and pervasive developmental disorder characterized by social difficulties, communicative deficits, and repetitive behavior. The increased rate of ASD diagnosis has raised questions concerning t...
Repairing the Brain by SCF+G-CSF Treatment at 6 Months Postexperimental Stroke: Mechanistic Determination of the Causal Link Between Neurovascular Regeneration and Motor Functional Recovery [0.03%]
SCF+G-CSF治疗改善脑卒中半年后遗症的疗效及机制研究：神经血管再生与运动功能恢复因果关系的实验证据
Lili Cui,Dandan Wang,Sandra McGillis et al.
Lili Cui et al.
Stroke, a leading cause of adult disability in the world, is a severe medical condition with limited treatment. Physical therapy, the only treatment available for stroke rehabilitation, appears to be effective within 6 months post-stroke. H...
Antioxidant Protection of NADPH-Depleted Oligodendrocyte Precursor Cells Is Dependent on Supply of Reduced Glutathione [0.03%]
抗氧化保护依赖于还原型谷胱甘肽的供给：NADPH缺乏的少突前体细胞中的抗氧化保护依赖于还原型谷胱甘肽的供给
Ewa Kilanczyk,Sujata Saraswat Ohri,Scott R Whittemore et al.
Ewa Kilanczyk et al.
The pentose phosphate pathway is the main source of NADPH, which by reducing oxidized glutathione, contributes to antioxidant defenses. Although oxidative stress plays a major role in white matter injury, significance of NADPH for oligodend...
A Complex Interaction Between Reduced Reelin Expression and Prenatal Organophosphate Exposure Alters Neuronal Cell Morphology [0.03%]
雷林表达降低与产前磷酸盐暴露相互作用影响神经元细胞形态
Brian R Mullen,Brennan Ross,Joan Wang Chou et al.
Brian R Mullen et al.
Genetic and environmental factors are both likely to contribute to neurodevelopmental disorders including schizophrenia, autism spectrum disorders, and major depressive disorders. Prior studies from our laboratory and others have demonstrat...
Mikkel Bredholt,Jette Lautrup Frederiksen
Mikkel Bredholt
In the last 35 years, zinc (Zn) has been examined for its potential role in the disease multiple sclerosis (MS). This review gives an overview of the possible role of Zn in the pathogenesis of MS as well as a meta-analysis of studies having...
Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy [0.03%]
缺失PERK改善S63del-Charcot-Marie-Tooth 1B周围神经病的髓鞘形成
Nicolò Musner,Mariapaola Sidoli,Desireè Zambroni et al.
Nicolò Musner et al.
In peripheral nerves, P0 glycoprotein accounts for more than 20% of myelin protein content. P0 is synthesized by Schwann cells, processed in the endoplasmic reticulum (ER) and enters the secretory pathway. However, the mutant P0 with S63 de...
Hydroxysafflor Yellow A Protects Neurons From Excitotoxic Death through Inhibition of NMDARs [0.03%]
羟基红花黄色素A通过抑制N-甲基-D天冬氨酸受体保护神经元免于兴奋毒性损伤
Xingtao Wang,Zhiyuan Ma,Zhongxiao Fu et al.
Xingtao Wang et al.
Excessive glutamate release causes overactivation of N-methyld-aspartate receptors (NMDARs), leading to excitatory neuronal damage in cerebral ischemia. Hydroxysafflor yellow A (HSYA), a compound extracted from Carthamus tinctorius L., has ...