Peripheral Inflammation, Apolipoprotein E4, and Amyloid-β Interact to Induce Cognitive and Cerebrovascular Dysfunction [0.03%]
外周炎症、载脂蛋白E4和淀粉样蛋白-β的相互作用诱导认知功能障碍和脑血管功能障碍
Felecia M Marottoli,Yuriko Katsumata,Kevin P Koster et al.
Felecia M Marottoli et al.
Cerebrovascular dysfunction is rapidly reemerging as a major process of Alzheimer's disease (AD). It is, therefore, crucial to delineate the roles of AD risk factors in cerebrovascular dysfunction. While apolipoprotein E4 ( APOE4), Amyloid-...
Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells [0.03%]
造血祖细胞命运决定影响人诱导多能干细胞来源的小胶质细胞样细胞TREM2表达
Peter J Amos,Susan Fung,Amanda Case et al.
Peter J Amos et al.
Microglia are the primary innate immune cell type in the brain, and their dysfunction has been linked to a variety of central nervous system disorders. Human microglia are extraordinarily difficult to obtain for experimental investigation, ...
Mariagiovanna Cantone,Alessia Bramanti,Giuseppe Lanza et al.
Mariagiovanna Cantone et al.
Neural plasticity is considered the neurophysiological correlate of learning and memory, although several studies have also noted that it plays crucial roles in a number of neurological and psychiatric diseases. Indeed, impaired brain plast...
Heterogeneity of D-Serine Distribution in the Human Central Nervous System [0.03%]
人中枢神经系统D-丝氨酸的分布异质性
Masataka Suzuki,Nobuaki Imanishi,Masashi Mita et al.
Masataka Suzuki et al.
D-serine is an endogenous ligand for N-methyl-D-aspartate glutamate receptors. Accumulating evidence including genetic associations of D-serine metabolism with neurological or psychiatric diseases suggest that D-serine is crucial in human n...
PACAP Promotes Matrix-Driven Adhesion of Cultured Adult Murine Neural Progenitors [0.03%]
PACAP促进培养的小鼠成年神经祖细胞的基质依赖性黏附作用
James A Waschek,Joseph R Cohen,Gloria C Chi et al.
James A Waschek et al.
New neurons are born throughout the life of mammals in germinal zones of the brain known as neurogenic niches: the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus of the hippocampus. These niches ...
Conditional Depletion of Hippocampal Brain-Derived Neurotrophic Factor Exacerbates Neuropathology in a Mouse Model of Alzheimer's Disease [0.03%]
阿尔茨海默病小鼠模型中海马脑源性神经营养因子的条件性耗竭加剧了神经病理表型
David J Braun,Sergey Kalinin,Douglas L Feinstein
David J Braun
Damage occurring to noradrenergic neurons in the locus coeruleus (LC) contributes to the evolution of neuroinflammation and neurodegeneration in a variety of conditions and diseases. One cause of LC damage may be loss of neurotrophic suppor...
Loss of Interneuron-Derived Collagen XIX Leads to a Reduction in Perineuronal Nets in the Mammalian Telencephalon [0.03%]
哺乳动物端脑中神经元源性ⅩⅨ型胶原蛋白的丢失导致星形网减少
Jianmin Su,James Cole,Michael A Fox
Jianmin Su
Perineuronal nets (PNNs) are lattice-like supramolecular assemblies of extracellular glycoproteins that surround subsets of neuronal cell bodies in the mammalian telencephalon. PNNs emerge at the end of the critical period of brain developm...
Unaltered Glutamate Transporter-1 Protein Levels in Aquaporin-4 Knockout Mice [0.03%]
Aquaporin-4敲除小鼠中未改变的谷氨酸转运蛋白-1蛋白质水平
Jacqueline A Hubbard,Devin K Binder
Jacqueline A Hubbard
Maintenance of glutamate and water homeostasis in the brain is crucial to healthy brain activity. Astrocytic glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) are the main regulators of extracellular glutamate and osmolarity, respective...
C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta [0.03%]
C5a增加由淀粉样蛋白β原纤维引起的初级神经元损伤
Michael X Hernandez,Pouya Namiranian,Eric Nguyen et al.
Michael X Hernandez et al.
C5aR1, the proinflammatory receptor for C5a, is expressed in the central nervous system on microglia, endothelial cells, and neurons. Previous work demonstrated that the C5aR1 antagonist, PMX205, decreased amyloid pathology and suppressed c...
NCAM1 Polysialylation: The Prion Protein's Elusive Reason for Being? [0.03%]
NCAM1多唾液酸化：神秘存在的朊蛋白的作用机制？
Mohadeseh Mehrabian,Herbert Hildebrandt,Gerold Schmitt-Ulms
Mohadeseh Mehrabian
Much confusion surrounds the physiological function of the cellular prion protein (PrPC). It is, however, anticipated that knowledge of its function will shed light on its contribution to neurodegenerative diseases and suggest ways to inter...