Stuck in a State of Inattention? Functional Hyperconnectivity as an Indicator of Disturbed Intrinsic Brain Dynamics in Adolescents With Concussion: A Pilot Study [0.03%]
注意不足？功能性高连接性作为青少年脑震荡患者内在脑动力学紊乱的指标：一项试点研究
Angela M Muller,Naznin Virji-Babul
Angela M Muller
Sports-related concussion in youth is a major public health issue. Evaluating the diffuse and often subtle changes in structure and function that occur in the brain, particularly in this population, remains a significant challenge. The goal...
Iron Deficiency Affects Seizure Susceptibility in a Time- and Sex-Specific Manner [0.03%]
缺铁通过时间和性别特定的方式影响癫痫的易感性
Michael Rudy,Margot Mayer-Proschel
Michael Rudy
Iron deficiency (ID) affects more than three billion people worldwide making it the most common micronutrient deficiency. ID is most prevalent during gestation and early life, which is of particular concern since its impact on the developin...
Kareem Clark,Brooke A Sword,Jeffrey L Dupree
Kareem Clark
The axon initial segment (AIS), the domain responsible for action potential initiation and maintenance of neuronal polarity, is targeted for disruption in a variety of central nervous system pathological insults. Previous work in our labora...
Hyperhomocysteinemia-Induced Gene Expression Changes in the Cell Types of the Brain [0.03%]
高同型半胱氨酸血症引起的脑细胞类型的基因表达变化
Erica M Weekman,Abigail E Woolums,Tiffany L Sudduth et al.
Erica M Weekman et al.
High plasma levels of homocysteine, termed hyperhomocysteinemia, are a risk factor for vascular cognitive impairment and dementia, which is the second leading cause of dementia. While hyperhomocysteinemia induces microhemorrhages and cognit...
Tissue Inhibitor of Metalloproteinase-3 Promotes Schwann Cell Myelination [0.03%]
组织金属蛋白酶抑制物-3促进施万细胞髓鞘化
Jihyun Kim,Anthony Elias,Taeweon Lee et al.
Jihyun Kim et al.
Tissue inhibitor of metalloproteinase-3 (TIMP-3) inhibits the activities of various metalloproteinases including matrix metalloproteinases and ADAM family proteins. In the peripheral nervous system, ADAM17, also known as TNF-α converting e...
Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus [0.03%]
MAPK1介导的信号通路参与缺血性脑卒中后癫痫发生发展的作用及机制研究
Yun-Sik Choi,Paul Horning,Sydney Aten et al.
Yun-Sik Choi et al.
Mitogen-activated protein kinase (MAPK) signaling has been implicated in a wide range of neuronal processes, including development, plasticity, and viability. One of the principal downstream targets of both the extracellular signal-regulate...
An Alternative Cuprizone-Induced Demyelination and Remyelination Mouse Model [0.03%]
一种备选的杯扎酮诱导的小鼠脱髓鞘和少突胶质细胞再生模型
Wei Zhen,Ailian Liu,Jiaqi Lu et al.
Wei Zhen et al.
The cuprizone model is a well-established and investigated paradigm to study demyelination and remyelination in rodents. Cuprizone is usually administrated by mixing in the powdered or pelleted rodent chow. However, since cuprizone is sensi...
Dissecting Amyloid Beta Deposition Using Distinct Strains of the Neurotropic Parasite Toxoplasma gondii as a Novel Tool [0.03%]
利用神经嗜性寄生虫弓形虫的不同菌株解剖淀粉样蛋白β沉积物的新方法
Carla M Cabral,Kathryn E McGovern,Wes R MacDonald et al.
Carla M Cabral et al.
Genetic and pathologic data suggest that amyloid beta (Aβ), produced by processing of the amyloid precursor protein, is a major initiator of Alzheimer's disease (AD). To gain new insights into Aβ modulation, we sought to harness the power...
Effects of Intron 1 Sequences on Human PLP1 Expression: Implications for PLP1-Related Disorders [0.03%]
PLP1内含子I序列对人类PLP1表达的影响及其与PLP1相关疾病的关系
Patricia A Wight
Patricia A Wight
Alterations in the myelin proteolipid protein gene ( PLP1) may result in rare X-linked disorders in humans such as Pelizaeus-Merzbacher disease and spastic paraplegia type 2. PLP1 expression must be tightly regulated since null mutations, a...
Nicotinic Receptor Abnormalities in the Cerebellar Cortex of Sudden Unexplained Fetal and Infant Death Victims-Possible Correlation With Maternal Smoking [0.03%]
sudden unexplained胎儿和婴儿死亡者小脑皮层中乙酰胆碱受体异常-与母体吸烟的可能联系
Anna M Lavezzi,Stefano Ferrero,Luca Roncati et al.
Anna M Lavezzi et al.
Nicotinic acetylcholine receptors (nAChRs) are cationic channels of the neuronal cell membrane, differentially expressed in the central nervous system which, when activated by endogenous acetylcholine or exogenous nicotine, are able to enha...