Knockdown of Annexin-A1 Inhibits Growth, Migration and Invasion of Glioma Cells by Suppressing the PI3K/Akt Signaling Pathway [0.03%]
敲除 Annexin-A1通过抑制PI3K/Akt信号通路抑制胶质瘤细胞的生长、迁移和侵袭
Liqing Wei,Li Li,Li Liu et al.
Liqing Wei et al.
ANXA1, which can bind phospholipid in a calcium dependent manner, is reported to play a pivotal role in tumor progression. However, the role and mechanism of ANXA1 involved in the occurrence and development of malignant glioma are still not...
Intermittent Lipopolysaccharide Exposure Significantly Increases Cortical Infarct Size and Impairs Autophagy [0.03%]
间断内毒素暴露显著增加脑梗死体积并抑制自噬
Ashley E Russell,John Z Cavendish,Ali Rai et al.
Ashley E Russell et al.
Globally, stroke is a leading cause of death and disability. Traditional risk factors like hypertension, diabetes, and obesity do not fully account for all stroke cases. Recent infection is regarded as changes in systemic immune signaling, ...
Michael Brenner,Albee Messing
Michael Brenner
Expression of the GFAP gene has attracted considerable attention because its onset is a marker for astrocyte development, its upregulation is a marker for reactive gliosis, and its predominance in astrocytes provides a tool for their geneti...
Upregulated SK2 Expression and Impaired CaMKII Phosphorylation Are Shared Synaptic Defects Between 16p11.2del and 129S: Δdisc1 Mutant Mice [0.03%]
16p11.2微缺失和ΔDISC1突变小鼠共有的神经元树突发育缺陷及机制研究
Razia Sultana,Tanya Ghandi,Alexandra M Davila et al.
Razia Sultana et al.
Ion channel gating and kinase regulation of N-methyl-D-aspartate receptor 1 activity are fundamental mechanisms that govern synaptic plasticity. In this study, we showed that two mutant models (16p11.2del and Δdisc1) that recapitulate aspe...
The Potential Roles of Redox Enzymes in Alzheimer's Disease: Focus on Thioredoxin [0.03%]
硫氧还蛋白等氧化还原酶在阿尔茨海默病中的潜在作用
Jinjing Jia,Xiansi Zeng,Guangtao Xu et al.
Jinjing Jia et al.
Alzheimer's disease (AD) is the most common neurodegenerative diseases. Increasing studies have demonstrated the critical importance for redox proteins mediating neuronal protection in models of AD. This review briefly describes some of the...
Sex Effect on Cardiac Damage in Mice With Experimental Autoimmune Encephalomyelitis [0.03%]
小鼠实验性自身免疫性脑脊髓炎的性别差异对心脏损伤的影响
Ruixia Wu,Yue Su,Quan Yuan et al.
Ruixia Wu et al.
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Recent clinical study suggested that MS patient exhibited acute heart failure. Further, 12-lead electrocardiographic study showed a longer QTc interval i...
miRNAs in Microglia: Important Players in Multiple Sclerosis Pathology [0.03%]
小胶质细胞中的miRNA在多发性硬化症病理中扮演重要角色
Alexander D Walsh,Linda T Nguyen,Michele D Binder
Alexander D Walsh
Microglia are the resident immune cells of the central nervous system and important regulators of brain homeostasis. Central to this role is a dynamic phenotypic plasticity that enables microglia to respond to environmental and pathological...
A Simplified Method for the Histochemical Detection of Iron in Paraffin Sections: Intracellular Iron Deposits in Central Nervous System Tissue [0.03%]
铁的组织化学染色的一种简化方法及中枢神经系统内细胞内铁沉着的研究
Steven M LeVine,Hao Zhu,Sarah E Tague
Steven M LeVine
Although all cells contain iron, most histochemical methods fail to reveal the presence of iron within many cells of the central nervous system (CNS), particularly neurons. Previously, a sensitive method was developed that limited the extra...
Role of G-Substrate in the NO/cGMP/PKG Signal Transduction Pathway for Photic Entrainment of the Hamster Circadian Clock [0.03%]
G-底物在夜行鼠视网膜钟光导入的环磷酸鸟苷/蛋白激酶G信号通路中的作用研究
Santiago Andrés Plano,María Soledad Alessandro,Laura Lucía Trebucq et al.
Santiago Andrés Plano et al.
The mammalian circadian clock at the hypothalamic suprachiasmatic nuclei (SCN) entrains biological rhythms to the 24-h cyclic environment, by encoding light-dark transitions in SCN neurons. Light pulses induce phase shifts in the clock and ...