The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets [0.03%]
NLRP3炎症小体在脑血管疾病发病机制及潜在治疗靶点中的作用
Rongrong Bai,Yue Lang,Jie Shao et al.
Rongrong Bai et al.
Cerebrovascular diseases are pathological conditions involving impaired blood flow in the brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid haemorrhage. The nucleotide-binding and oligomerisation (NOD) ...
PET Imaging of Peripheral Benzodiazepine Receptor Standard Uptake Value Increases After Controlled Cortical Impact, a Rodent Model of Traumatic Brain Injury [0.03%]
外周型苯二氮卓受体正电子发射断层显像标准摄取值在控制性脑挫伤后的变化：一项创伤性脑损伤动物模型研究
Benjamin M Aertker,Akshita Kumar,Fanni Cardenas et al.
Benjamin M Aertker et al.
Traumatic brain injury (TBI) is a chronic, life threatening injury for which few effective interventions are available. Evidence in animal models suggests un-checked immune activation may contribute to the pathophysiology. Changes in region...
Antioxidant Blend of Curcumin and Broccoli Seed Extract Exhibits Protective Effect on Neurodegeneration and Promotes Drosophila Lifespan [0.03%]
姜黄素和 broccoli 种子提取物的抗氧化复合物可保护神经退行性病变并延长果蝇寿命
Jingjing Cheng,Honglei Wang,Mark Bartlett et al.
Jingjing Cheng et al.
Antioxidants and related compounds are anti-inflammatory and exhibit great potential in promoting human health. They are also often considered to be important elements in the process of neurodegeneration. Here we describe a antioxidant blen...
Restoration of Noradrenergic Function in Parkinson's Disease Model Mice [0.03%]
帕金森病模型小鼠noradrenergic功能的恢复
Kui Cui,Fan Yang,Turan Tufan et al.
Kui Cui et al.
Dysfunction of the central noradrenergic and dopaminergic systems is the primary neurobiological characteristic of Parkinson's disease (PD). Importantly, neuronal loss in the locus coeruleus (LC) that occurs in early stages of PD may accele...
The Contribution of Astrocyte and Neuronal Panx1 to Seizures Is Model and Brain Region Dependent [0.03%]
星形胶质细胞和神经元Panx1对癫痫的贡献取决于模型和脑区
Price Obot,Libor Velíšek,Jana Velíšková et al.
Price Obot et al.
Pannexin1 (Panx1) is an ATP release channel expressed in neurons and astrocytes that plays important roles in CNS physiology and pathology. Evidence for the involvement of Panx1 in seizures includes the reduction of epileptiform activity an...
Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis [0.03%]
芍药醇通过介导HOTAIR/UPF1/ACSL4轴抑制脑出血发展
Zheng-Long Jin,Wen-Ying Gao,Shao-Jun Liao et al.
Zheng-Long Jin et al.
Intracerebral haemorrhage (ICH) is a devastating subtype of stroke with high morbidity and mortality. It has been reported that paeonol (PAN) inhibits the progression of ICH. However, the mechanism by which paeonol mediates the progression ...
High-Throughput Sequencing of BACHD Mice Reveals Upregulation of Neuroprotective miRNAs at the Pre-Symptomatic Stage of Huntington's Disease [0.03%]
高通量测序发现BACHD小鼠在亨廷顿舞蹈病前症状期神经保护性miRNA的上调
Isabella G Olmo,Roenick P Olmo,André N A Gonçalves et al.
Isabella G Olmo et al.
Huntington's disease (HD) is a genetic disorder marked by transcriptional alterations that result in neuronal impairment and death. MicroRNAs (miRNAs) are non-coding RNAs involved in post-transcriptional regulation and fine-tuning of gene e...
Susann Hetze,Ulrich Sure,Manfred Schedlowski et al.
Susann Hetze et al.
Animal models are still indispensable for understanding the basic principles of glioma development and invasion. Preclinical approaches aim to analyze the treatment efficacy of new drugs before translation into clinical trials is possible. ...
Characterization of the Expression of Vacuolar Protein Sorting 11 (Vps11) in Mammalian Oligodendrocytes [0.03%]
哺乳动物少突胶质细胞中囊泡转运相关蛋白Vps11的表达特征分析
Robert P Skoff,Denise Bessert,Shreya Banerjee et al.
Robert P Skoff et al.
A founder mutation in human VPS11 (Vacuolar Protein Sorting 11) was recently linked to a genetic leukoencephalopathy in Ashkenazi Jews that presents with the classical features of white matter disorders of the central nervous system (CNS). ...
LncRNA TUG1 Demethylated by TET2 Promotes NLRP3 Expression, Contributes to Cerebral Ischemia/Reperfusion Inflammatory Injury [0.03%]
TET2脱甲基化lncRNA TUG1促进NLRP3表达并促進脑缺血再灌注炎症损伤
Min Yin,Wei-Ping Chen,Xiao-Ping Yin et al.
Min Yin et al.
LncRNA TUG1 has not yet been reported in cerebral ischemia/reperfusion (I/R) injury. Methylcytosine dioxygenase TET2 is involved in ischemic damage. This study aimed to investigate the effects of TUG1 demethylated by TET2 on I/R-induced inf...