Emerging Role of Ferroptosis in the Pathogenesis of Ischemic Stroke: A New Therapeutic Target? [0.03%]
铁死亡在缺血性卒中发病机制中的新兴作用：新的治疗靶点？
Zhong-Qi Bu,Hai-Yang Yu,Jue Wang et al.
Zhong-Qi Bu et al.
Ischemic stroke is one of the main causes of high morbidity, mortality, and disability worldwide; however, the treatment methods are limited and do not always achieve satisfactory results. The pathogenesis of ischemic stroke is complex, def...
Restoration of KCC2 Membrane Localization in Striatal Dopamine D2 Receptor-Expressing Medium Spiny Neurons Rescues Locomotor Deficits in HIV Tat-Transgenic Mice [0.03%]
D2型多巴胺受体表达中棘神经元中KCC2膜定位的恢复可修复HIV-TAT转基因小鼠的运动缺陷
Aaron J Barbour,Sara R Nass,Yun K Hahn et al.
Aaron J Barbour et al.
People infected with HIV (PWH) are highly susceptible to striatal and hippocampal damage. Motor and memory impairments are common among these patients, likely as behavioral manifestations of damage to these brain regions. GABAergic dysfunct...
Bipul Ray,Abid Bhat,Arehally Marappa Mahalakshmi et al.
Bipul Ray et al.
Mitochondrial dysfunction is a well-established pathological event in Parkinson's disease (PD). Proteins misfolding and its impaired cellular clearance due to altered autophagy/mitophagy/pexophagy contribute to PD progression. It has been s...
Oxytocin Modulation of Maternal Behavior and Its Association With Immunological Activity in Rats With Cesarean Delivery [0.03%]
oxytocin对剖宫产大鼠母性行为及免疫活性的影响
Tong Li,Shu-Wei Jia,Dan Hou et al.
Tong Li et al.
Oxytocin (OT), a neuropeptide produced in the supraoptic (SON) and paraventricular (PVN) nuclei, is not only essential for lactation and maternal behavior but also for normal immunological activity. However, mechanisms underlying OT regulat...
Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8- Positive (AT8+) Tau in Alzheimer's Disease [0.03%]
基于代谢的基因差异表达高磷酸化AT8阳性（AT8+）Tau蛋白的神经元在阿尔茨海默病中的作用
Audra York,Angela Everhart,Michael P Vitek et al.
Audra York et al.
Metabolic adaptations in the brain are critical to the establishment and maintenance of normal cellular functions and to the pathological responses to disease processes. Here, we have focused on specific metabolic pathways that are involved...
Melatonin Protects Against Ischemic Brain Injury by Modulating PI3K/AKT Signaling Pathway via Suppression of PTEN Activity [0.03%]
褪黑素通过抑制PTEN活性调节PI3K/AKT信号通路从而保护缺血性脑损伤
Yuanyuan Ran,Lin Ye,Zitong Ding et al.
Yuanyuan Ran et al.
Stroke is one of the leading causes of death and disability worldwide with limited therapeutic options. Melatonin can attenuate ischemic brain damage with improved functional outcomes. However, the cellular mechanisms of melatonin-driven ne...
Aspergillus versicolor Inhalation Triggers Neuroimmune, Glial, and Neuropeptide Transcriptional Changes [0.03%]
烟曲霉吸入诱发神经免疫、胶质和神经肽转录变化
Thatcher B Ladd,James A Johnson Jr,Christen L Mumaw et al.
Thatcher B Ladd et al.
Increasing evidence associates indoor fungal exposure with deleterious central nervous system (CNS) health, such as cognitive and emotional deficits in children and adults, but the specific mechanisms by which it might impact the brain are ...
Neuronal Pentraxin 1 Promotes Hypoxic-Ischemic Neuronal Injury by Impairing Mitochondrial Biogenesis via Interactions With Active Bax[6A7] and Mitochondrial Hexokinase II [0.03%]
神经五聚素1通过与活化型Bax及线粒体己糖激酶II的相互作用损害线粒体生物发生从而促进缺氧缺血性神经元损伤
Md Al Rahim,Shabarish Thatipamula,Giulio M Pasinetti et al.
Md Al Rahim et al.
Mitochondrial dysfunction is a key mechanism of cell death in hypoxic-ischemic brain injury. Neuronal pentraxin 1 (NP1) has been shown to play crucial roles in mitochondria-mediated neuronal death. However, the underlying mechanism(s) of NP...
Kacey Berry,Daniela S Farias-Itao,Lea T Grinberg et al.
Kacey Berry et al.
One hallmark of human aging is increased brain inflammation represented by glial activation. With age, there is also diminished function of the adaptive immune system, and modest decreases in circulating B- and T-lymphocytes. Lymphocytes tr...
Gut Microbiota and Parkinson's Disease: Implications for Faecal Microbiota Transplantation Therapy [0.03%]
肠道微生物群与帕金森病：粪菌移植治疗的启示
Yongbo Kang,Xing Kang,Hongfang Zhang et al.
Yongbo Kang et al.
Parkinson's disease (PD) ranks the second place among neurodegenerative diseases in terms of its morbidity, which affects 1-2% people aged over 65 years. In addition to genetics, some environmental factors may exert vital parts in PD occurr...