Identification of miRNAs That Mediate Protective Functions of Anti-Cancer Drugs During White Matter Ischemic Injury [0.03%]
识别在白色物质缺血损伤过程中介导抗癌药物保护功能的miRNAs
Selva Baltan,Ursula S Sandau,Sylvain Brunet et al.
Selva Baltan et al.
We have previously shown that two anti-cancer drugs, CX-4945 and MS-275, protect and preserve white matter (WM) architecture and improve functional recovery in a model of WM ischemic injury. While both compounds promote recovery, CX-4945 is...
Chitra Mohinder Singh Singal,Paritosh Jaiswal,Anuradha Mehta et al.
Chitra Mohinder Singh Singal et al.
Glial cells perform important supporting functions for neurons through a dynamic crosstalk. Neuron-glia communication is the major phenomenon to sustain homeostatic functioning of the brain. Several interactive pathways between neurons and ...
American Society of Neurochemistry
American Society of Neurochemistry
Glycogen Phosphorylase Isoform Regulation of Ventromedial Hypothalamic Nucleus Gluco-Regulatory Neuron 5'-AMP-Activated Protein Kinase and Transmitter Marker Protein Expression [0.03%]
糖原磷酸化酶同工酶调节腹内侧下丘脑核 glucoregulatory 神经元的 5'-AMP 活化蛋白激酶和神经递质标志蛋白表达
Md Main Uddin,Mostafa M H Ibrahim,Karen P Briski
Md Main Uddin
Brain glycogen is remodeled during metabolic homeostasis and provides oxidizable L-lactate equivalents. Brain glycogen phosphorylase (GP)-brain (GPbb; AMP-sensitive) and -muscle (GPmm; norepinephrine-sensitive) type isoforms facilitate stim...
A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury [0.03%]
肿瘤坏死因子超家族成员15在脑出血继发性脑损伤中的保护作用
Gui-Li Yang,Shizhao Wang,Shu Zhang et al.
Gui-Li Yang et al.
Destabilization of blood vessels by the activities of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) following intracerebral hemorrhage (ICH) has been considered the main causes of aggravated secondary brain ...
Forelimb Motor Skills Deficits Following Thoracic Spinal Cord Injury: Underlying Dopaminergic and Neural Oscillatory Changes in Rat Primary Motor Cortex [0.03%]
胸脊髓损伤后的前肢运动技能缺陷：大脑初级运动皮层的多巴胺能及神经振荡变化
Omid Salimi,Hamid Soltani Zangbar,Soheila Hajizadeh Shadiabad et al.
Omid Salimi et al.
The loss of spinal sensorimotor pathways following spinal cord injury (SCI) can induce retrograde neurodegeneration in the primary motor cortex (M1). However, the effect of thoracic SCI on forelimb motor skills has not been studied clearly....
Astrocytic Hydrogen Sulfide Regulates Supraoptic Cellular Activity in the Adaptive Response of Lactating Rats to Chronic Social Stress [0.03%]
星形胶质细胞硫化氢调控乳鼠在抵抗慢行社会压力的适应反应中超光标细胞的活性
Dongyang Li,Haitao Liu,Hongyang Wang et al.
Dongyang Li et al.
Maternal social stress among breastfeeding women can be adapted in chronic process. However, neuroendocrine mechanisms underlying such adaptation remain to be identified. Here, we report the effects of 2 hr/day unfamiliar male rat invasion ...
Microglial- and Astrocyte-Specific Expression of Purinergic Signaling Components and Inflammatory Mediators in the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration [0.03%]
三甲基锡诱导的神经退行过程中大鼠海马中微胶质细胞和星形胶质细胞特异性表达嘌呤能信号成分和炎症介质
Milorad Dragić,Nataša Mitrović,Marija Adžić et al.
Milorad Dragić et al.
The present study examined the involvement of purinergic signaling components in the rat model of hippocampal degeneration induced by trimethyltin (TMT) intoxication (8 mg/kg, single intraperitoneal injection), which results in behavioral a...
Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes [0.03%]
一氧化氮通过Janus激酶1诱导小胶质细胞炎症反应
John D Nowery,Rylee N Cisney,Jacob W Feldmann et al.
John D Nowery et al.
Nitric oxide (NO) is a versatile free radical that has been implicated in many biological processes (i.e., vasodilation, neurotransmission, and smooth muscle relaxation). High levels of NO, such as those produced by inducible NO synthase, a...
17β-Estradiol Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Injury and Oxidative Stress Through SRC3-Mediated PI3K/Akt Signaling Pathway in a Mouse Model [0.03%]
雌二醇通过SRC3介导的PI3K/AKT信号通路减轻ICH诱导的血脑屏障损伤和氧化应激（小鼠模型）
Han Xiao,Jianyang Liu,Jialin He et al.
Han Xiao et al.
Estrogen is neuroprotective in brain injury models, and steroid receptor cofactor 3 (SRC3) mediates estrogen signaling. We aimed to investigate whether and how SRC3 is involved in the neuroprotective effects of 17ß-estradiol (E2) in a mous...