Optimization of Long-Term Human iPSC-Derived Spinal Motor Neuron Culture Using a Dendritic Polyglycerol Amine-Based Substrate [0.03%]
一种基于树状聚甘油胺衍生物底物长期培养人诱导多能干细胞来源的脊髓运动神经元的研究
Louise Thiry,Jean-Pierre Clément,Rainer Haag et al.
Louise Thiry et al.
Human induced pluripotent stem cells (hiPSCs) derived from healthy and diseased individuals can give rise to many cell types, facilitating the study of mechanisms of development, human disease modeling, and early drug target validation. In ...
Dendritic Polyglycerol Amine: An Enhanced Substrate to Support Long-Term Neural Cell Culture [0.03%]
以树枝状聚甘油胺为基底的长期培养神经细胞系的新进展
Jean-Pierre Clément,Laila Al-Alwan,Stephen D Glasgow et al.
Jean-Pierre Clément et al.
Long-term stable cell culture is a critical tool to better understand cell function. Most adherent cell culture models require a polymer substrate coating of poly-lysine or poly-ornithine for the cells to adhere and survive. However, polype...
Carboxypeptidase E Independently Changes Microtubule Glutamylation, Dendritic Branching, and Neuronal Migration [0.03%]
羧肽酶E独立调节微管谷氨酰化、树突分枝及神经元迁移
Chen Liang,Damien Carrel,Nisha K Singh et al.
Chen Liang et al.
Neuronal migration and dendritogenesis are dependent on dynamic changes to the microtubule (MT) network. Among various factors that regulate MT dynamics and stability, post-translational modifications (PTMs) of MTs play a critical role in c...
Effects of Manipulation of Noradrenergic Activities on the Expression of Dopaminergic Phenotypes in Aged Rat Brains [0.03%]
肾上腺素能活性的干预对大鼠脑多巴胺能表型表达的影响
Fei Zeng,Yan Fan,Russell W Brown et al.
Fei Zeng et al.
This study investigated the effects of the pharmacological manipulation of noradrenergic activities on dopaminergic phenotypes in aged rats. Results showed that the administration of L-threo-3,4-dihydroxyphenylserine (L-DOPS) for 21 days si...
Mechanism of Incisional Pain: Novel Finding on Long Noncoding RNA XIST/miR-340-5p/RAB1A Axis [0.03%]
切口痛的机制：长链非编码RNA XIST/miR-340-5p/RAB1A轴的新发现
Juan Liao,Fan Zhang,Wenxiang Qing et al.
Juan Liao et al.
The objective of this study is to investigate the effect of long noncoding RNA (lncRNA) XIST on postoperative pain and inflammation of plantar incision pain (PIP) in rats and its underlying mechanisms.PIP rat models were established by plan...
Hayder M Al-Kuraishy,Ali I Al-Gareeb,Safaa Qusti et al.
Hayder M Al-Kuraishy et al.
Among the plethora of debilitating neurological disorders of COVID-19 syndrome in survivors, the scope of SARS-CoV-2-induced dysautonomia (DNS) is yet to be understood, though the implications are enormous. Herein, we present an inclusive m...
Multicenter Study
ASN neuro. 2021 Jan-Dec:13:17590914211057635. DOI:10.1177/17590914211057635 2021
Sevoflurane-Induced miR-211-5p Promotes Neuronal Apoptosis by Inhibiting Efemp2 [0.03%]
七氟烷诱导的miR-211-5p通过抑制Efemp2促进神经元凋亡
Yousu Shen,Tao Zhou,Xiaobing Liu et al.
Yousu Shen et al.
Sevoflurane exposure can result in serious neurological side effects including neuronal apoptosis and cognitive impairment. Although the microRNA miR-211-5p is profoundly upregulated following sevoflurane exposure in neonatal rodent models,...
Dopamine receptor agonist rotigotine-loaded microspheres ameliorates sexual function deteriorated by fluoxetine in depression rats [0.03%]
多巴胺受体激动剂罗替戈汀负载微球改善了抑郁大鼠氟西汀所致性功能障碍
Wenqian Wang,Ce Zhang,Yiqian Fan et al.
Wenqian Wang et al.
Low dopamine levels may cause depressive symptoms. Dopamine is also involved in sexual behavior. Rotigotine is a nonergolinic dopamine agonist. Fluoxetine, an antidepressant that acts as a selective serotonin (5-HT) reuptake inhibitor, may ...
SangJoon Lee,Hyun-Jeong Cho,Jin-Hyeob Ryu
SangJoon Lee
The innate immune system plays key roles in controlling Alzheimer's disease (AD), while secreting cytokines to eliminate pathogens and regulating brain homeostasis. Recent research in the field of AD has shown that the innate immune-sensing...
The Mesencephalic Periaqueductal Gray, a Further Structure Involved in Breathing Failure Underlying Sudden Infant Death Syndrome [0.03%]
中脑导水管周围灰质，是突然婴儿死亡综合症呼吸衰竭的进一步结构之一
Anna M Lavezzi,Riffat Mehboob
Anna M Lavezzi
The aim of this study was to investigate the involvement of the periaqueductal gray (PAG), an area of gray matter surrounding the cerebral aqueduct of Sylvius, in the pathogenetic mechanism of SIDS, a syndrome frequently ascribed to arousal...