In Utero Exposure to Zika Virus Results in sex-Specific Memory Deficits and Neurological Alterations in Adult Mice [0.03%]
孕期接触寨胺病毒会导致小鼠成年后出现性别特异性的记忆缺失和神经学变化
Thiago A Andrade,Julia S Fahel,Jessica M de Souza et al.
Thiago A Andrade et al.
In utero exposure to ZIKV leads to decreased number of neurons in adult mice. Female mice exposed to ZIKV in utero exhibit lower levels of BDNF, a decrease in synaptic markers, memory deficits, and risk-taking behavior during adulthood. ...
Multiple Sclerosis and Aging: The Dynamics of Demyelination and Remyelination [0.03%]
多发性硬化和衰老：脱髓鞘与再髓鞘的动力学关系
Jorge Correale,Maria Celica Ysrraelit
Jorge Correale
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) leading to demyelination and neurodegeneration. Life expectancy and age of onset in MS patients have been rising over the last decades, and previo...
EAAT1-dependent slc1a3 Transcriptional Control depends on the Substrate Translocation Process [0.03%]
底物转运过程决定天冬氨酸转运蛋白EAAT1的转录调控
Dinorah Hernández-Melchor,Leticia Ramírez-Martínez,Luis Cid et al.
Dinorah Hernández-Melchor et al.
EAAT1/GLAST down-regulates its expression and function at the transcriptional level by activating a signaling pathway that includes PI3K, PKC and NF-κB, favoring the notion of an activity-dependent fine-tuning of glutamate recycling and it...
Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis [0.03%]
lanthionine ketimine乙酯加速小鼠多发性硬化模型的脱髓鞘修复
Jeffrey L Dupree,Pablo M Paez,Seema K Tiwari-Woodruff et al.
Jeffrey L Dupree et al.
Although over 20 disease modifying therapies are approved to treat Multiple Sclerosis (MS), these do not increase remyelination of demyelinated axons or mitigate axon damage. Previous studies showed that lanthionine ketenamine ethyl ester (...
GFAP Alternative Splicing and the Relevance for Disease - A Focus on Diffuse Gliomas [0.03%]
胶质纤维酸性蛋白( GFAP )可变剪接及在疾病中的相关性——以弥漫性 glioma 为例
Jessy V van Asperen,Pierre A J T Robe,Elly M Hol
Jessy V van Asperen
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is characteristic for astrocytes and neural stem cells, and their malignant analogues in glioma. Since the discovery of the protein 50 years ago, multiple alter...
Monica Lamas,Erick J Martinez-Colin
Monica Lamas
Müller glial cells exert multiple essential functions in retinal physiology and retinopathies reflecting perhaps the existence of distinct Müller cellular subpopulations. Harnessing Müller cell heterogeneity may serve to enhance new ther...
Ana María Rodríguez,Julia Rodríguez,Guillermo Hernán Giambartolomei
Ana María Rodríguez
Microglia are the resident tissue macrophages of the central nervous system (CNS). Recent findings point out that in the steady state the major role of microglia, is to instruct and regulate the correct function of the neuronal networks and...
Motor Learning and Physical Exercise in Adaptive Myelination and Remyelination [0.03%]
运动学习和体力锻炼在适应性髓鞘形成和再髓鞘化中的作用
Mara S Bloom,Jennifer Orthmann-Murphy,Judith B Grinspan
Mara S Bloom
The idea that myelination is driven by both intrinsic and extrinsic cues has gained much traction in recent years. Studies have demonstrated that myelination occurs in an intrinsic manner during early development and continues through adult...
Disruption of Synaptic Transmission in the Bed Nucleus of the Stria Terminalis Reduces Seizure-Induced Death in DBA/1 Mice and Alters Brainstem E/I Balance [0.03%]
破坏背侧纹状体终末核的突触传递可减少DBA/1小鼠癫痫诱发性死亡并改变脑干兴奋/抑制平衡
Maya Xia,Benjamin Owen,Jeremy Chiang et al.
Maya Xia et al.
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in refractory epilepsy patients. Accumulating evidence from recent human studies and animal models suggests that seizure-related respiratory arrest may be important f...