SuperAging is not the inverse of common-variant Alzheimer's risk: evidence across genetic ancestries [0.03%]
超老化并非常见阿尔茨海默病风险的逆向指标：跨遗传血统证据
Ignazio Stefano Piras,Ana Werneck Capuano,Amanda Cook Maher et al.
Ignazio Stefano Piras et al.
Background: As longevity increases and the population over age 65 expands, advancing age remains the most reliable predictor of cognitive decline, highlighting the need to identify biological mechanisms that support excep...
Personalized non-invasive combined magnetic and electrical stimulation of the default mode network in mild AD patients (CMES-AD): a multicentric randomized sham-controlled trial protocol [0.03%]
轻度阿尔茨海默病患者默认模式网络的个性化非侵入性联合磁电刺激临床试验（CMES-AD）方案：多中心随机假刺激对照试验
Sonia Bonnì,Romina Esposito,Lucia Mencarelli et al.
Sonia Bonnì et al.
Background: Patients with Alzheimer's disease (AD) exhibit early alterations in the Default Mode Network (DMN), a key brain network involved in episodic memory where the precuneus plays a central role. Precision-targeted,...
Blood-based immunophenotyping of T cell profiles in patients with neurodegenerative disorders [0.03%]
神经退行性疾病患者的血液T细胞免疫表型分析
Frederika Malichova,Peter Swann,Stacey L Kigar et al.
Frederika Malichova et al.
Background: There is increasing evidence for the role of central and peripheral inflammation across neurodegenerative disorders, with animal models and post-mortem studies identifying T-cell infiltration in the brain asso...
Resting-state functional dynamics alterations relate to plasma amyloid markers and statistically explain memory impairments in the TgF344-AD model of Alzheimer's disease [0.03%]
静息态功能动态改变与阿尔茨海默病小鼠模型脑脊液中Tau和淀粉样蛋白标志物相关并可解释记忆障碍
Alya Al-Awlaqi,Lori Berckmans,Sam De Waegenaere et al.
Alya Al-Awlaqi et al.
Background: Resting-state functional MRI studies of Alzheimer's disease (AD) show lower functional connectivity (FC) of AD-relevant regions and resting-state networks in patients and transgenic rodent models at symptomati...
Steroid hormones in Alzheimer's disease: a molecular analysis of blood and cerebrospinal fluid [0.03%]
阿尔茨海默病中的类固醇激素：血液和脑脊液的分子分析
Tik Muk,Asger Wretlind,Kourosh Hooshmand et al.
Tik Muk et al.
Background: Alzheimer's disease (AD) disproportionately affects women, yet existing studies have been limited to single biofluids, individual hormones, or single dementia subtypes, leaving sex-stratified profiles across t...
Sequential associations of myelin dysfunction with Aβ and Tau pathology in Alzheimer's disease: a dynamic myelin perturbation [0.03%]
阿尔茨海默病中髓鞘功能障碍与淀粉样蛋白和tau异常之间的顺序关联：髓鞘动态紊乱分析
Jingxiang Wen,Guoyu Lan,Yuan Fu et al.
Jingxiang Wen et al.
Background: Myelin dysfunction has emerged as a potentially pivotal factor in Alzheimer's disease (AD); however, its temporal dynamics and relationship with hallmark pathological processes remain incompletely understood. ...
Three-order interactions in the alpha band of default mode network EEGs based on O-information rate: insights from aging and Alzheimer's disease [0.03%]
基于O信息率的默认模式网络阿尔法频段三阶互作用：来自衰老和阿尔茨海默病的启示
Hamed Azami,Yuri Antonacci,Daniel M Blumberger et al.
Hamed Azami et al.
Background: Alpha-band default mode network (DMN) connectivity declines with aging and Alzheimer's disease (AD), yet most electroencephalography (EEG) connectivity studies used pairwise (two-order) measures, such as mutua...
Real-world safety and implementation challenges of lecanemab therapy for Alzheimer's disease in South Korea: a single-center experience [0.03%]
韩国阿兹海默病患者使用lecanemab疗法的现实世界安全性及实施挑战：单中心经验报告
Hyemin Jang,Jae Woo Kim,Jung Won Hwang et al.
Hyemin Jang et al.
Background: Lecanemab, an amyloid-targeting monoclonal antibody, was recently approved for early symptomatic Alzheimer's disease in South Korea. Asians were underrepresented in prior trials, and real-world data from Korea...
Disruption of temporo-parietal network in Alzheimer's disease and its association with memory impairment [0.03%]
阿尔茨海默病中顶颞网络的损伤及其与记忆障碍的关系研究
Yanin Suksangkharn,Björn Hendrik Schott,Peter Zeidman et al.
Yanin Suksangkharn et al.
Alzheimer's disease (AD) is characterised by the accumulation of β-amyloid (Aβ) and tau proteins, resulting in neurodegeneration and cognitive decline. Although Aβ and tau disrupt synaptic function, the association linking these molecula...
Multicenter Study
Alzheimer's research & therapy. 2026 Jul 15;18(1):166. DOI:10.1186/s13195-026-02138-w 2026
A probabilistic framework for clinicopathological Alzheimer's disease using tau-PET [0.03%]
基于tau-PET的临床病理阿尔茨海默病的概率框架研究
Bastiaan G J van Tol,Colin Groot,Marie R Vermeiren et al.
Bastiaan G J van Tol et al.
Background: [18F]flortaucipir tau-PET detects neurofibrillary tangle (NFT) pathology in Alzheimer's disease (AD), one of the core pathological hallmarks of the disease. In clinical settings, tau-PET is usually interpreted...