Muscle Endurance and Self-Perceived Fatigue Predict Decline in Gait Speed and Activities of Daily Living After 1-Year Follow-Up: Results From the BUTTERFLY Study [0.03%]
肌肉耐力和自我感知疲劳可以预测步速及日常生活活动能力的下降：蝴蝶研究一年后随访结果
Veerle Knoop,Axelle Costenoble,Aziz Debain et al.
Veerle Knoop et al.
Background: Fatigue might influence the losses in activities of daily living (ADL). When fatigue parameters are present before the experience of losses in ADL and gait speed, they can be used as early warning signals. Thi...
Relationship of Self-reported and Performance-based Visual Function With Performance-based Measures of Physical Function: The Health ABC Study [0.03%]
自报和基于性能的视觉功能与身体功能基于性能的测量的关系：健康ABC研究
Atalie C Thompson,Michael E Miller,Christopher C Webb et al.
Atalie C Thompson et al.
Background: To assess the relationship between self-reported and performance-based visual impairment (VI) and lower extremity physical function. Methods: ...
Early or Late-Life Treatment With Acarbose or Rapamycin Improves Physical Performance and Affects Cardiac Structure in Aging Mice [0.03%]
晚期或早期使用阿卡波糖或雷帕霉素可改善老年小鼠的身体机能并影响其心脏结构
Jonathan J Herrera,Kaitlyn Pifer,Sean Louzon et al.
Jonathan J Herrera et al.
Pharmacological treatments can extend the life span of mice. For optimal translation in humans, treatments should improve health during aging, and demonstrate efficacy when started later in life. Acarbose (ACA) and rapamycin (RAP) extend li...
Stratification of Companion Animal Life Stages from Electronic Medical Record Diagnosis Data [0.03%]
从电子病历诊断数据对伴侣动物生命阶段进行分层
Carina Salt,Emi K Saito,Ciaran O&#x;Flynn et al.
Carina Salt et al.
Aging is a complex, multifactorial process, where different life stages reflect changes in metabolic processes, immune capacities, and genetic/epigenetic repertoires. With accumulating exposure to environmental stresses and deterioration of...
Greater Phosphorylation of AMPK and Multiple AMPK Substrates in the Skeletal Muscle of 24-Month-Old Calorie Restricted Compared to Ad-Libitum Fed Male Rats [0.03%]
与自由采食的大鼠相比，限制热量摄入的雄性大鼠骨骼肌中AMPK及其多个底物磷酸化水平更高
Amy Zheng,Seong Eun Kwak,Jesper B Birk et al.
Amy Zheng et al.
AMP-activated protein kinase (AMPK), a highly conserved, heterotrimeric serine/threonine kinase with critical sensory and regulatory functions, is proposed to induce antiaging actions of caloric restriction (CR). Although earlier studies as...
The Mediating Role of Inflammation in the Relationship Between α-Synuclein and Cognitive Functioning [0.03%]
炎症在α-突触核蛋白与认知功能关系中的介导作用
Sanaz Dabiri,Mara I Ramírez Ruiz,Girardin Jean-Louis et al.
Sanaz Dabiri et al.
Accumulating evidence suggests that α-synuclein plays a role in the pathophysiology of Alzheimer's disease (AD). This study examined whether α-synuclein level in cerebrospinal fluid (CSF) was associated with cognitive functioning among ol...
COP27 Climate Change Conference: urgent action needed for Africa and the world [0.03%]
《 COP27气候大会：非洲和世界亟需采取行动》
Lukoye Atwoli,Gregory E Erhabor,Aiah A Gbakima et al.
Lukoye Atwoli et al.
Racial, Ethnic, and Socioeconomic Differences in a Deficit Accumulation Frailty Index in the Multiethnic Cohort Study [0.03%]
夏威夷多族裔队列研究中的虚弱指数的种族、民族和经济差异分析
Anna H Wu,V Wendy Setiawan,Daniel O Stram et al.
Anna H Wu et al.
Background: Frailty status has been sparsely studied in some groups including Native Hawaiians and Asian Americans. Methods: We develop...
Frailty Transitions in Older Persons With Lung Function Impairment: A Population-Based Study [0.03%]
肺功能不全老年人的衰弱状态转变：一项基于人群的研究
Sara R A Wijnant,Elizabeth Benz,Annemarie I Luik et al.
Sara R A Wijnant et al.
Background: The aging population and its burden on health care systems warrant early detection of patients at risk of functional decline and mortality. We aimed to assess frailty transitions and its accuracy for mortality...
Geriatric Frailty Is Associated With Oxidative Stress, Accumulation, and Defective Repair of DNA Double-Strand Breaks Independently of Age and Comorbidities [0.03%]
老年衰弱与氧化应激、DNA双链断裂积累及修复缺陷相关独立于年龄和共病状况
Evrydiki Kravvariti,Panagiotis A Ntouros,Nikolaos I Vlachogiannis et al.
Evrydiki Kravvariti et al.
Defects in the DNA damage response and repair (DDR/R) network accumulate during the aging process. Physical frailty, a state of reduced physiological function and decreased resilience to biological stressors, is also exacerbated by aging, b...