Prediction Abilities of SCORE2 Risk Algorithms for Incident Dementia and All-Cause Mortality: Results From the UK Biobank Cohort Study [0.03%]
SCORE2风险算法对新发痴呆和全因死亡的预测能力：来自英国生物银行队列研究的结果
Fanfan Zheng,Wuxiang Xie,Chenglong Li et al.
Fanfan Zheng et al.
Background: Whether the updated Systematic COronary Risk Evaluation (SCORE2) risk algorithm is suitable for the prediction of incident dementia and all-cause mortality and whether its discrimination abilities for these ou...
Mina S Sedrak,Harvey Jay Cohen
Mina S Sedrak
Aging is the largest risk factor for the development of cancer. A growing body of literature indicates that aging and cancer often play a somewhat reciprocal relationship at various times. On the one hand, aging is a "driver" of cancer, and...
Operationalization of Intrinsic Capacity in Older People and Its Association With Subsequent Disability, Hospital Admission and Mortality: Results From The English Longitudinal Study of Ageing [0.03%]
老年人内在能力的操作化定义及其与后续残疾、住院和死亡率的关系：来自英国老龄化纵向研究的结果
Charlotte L Campbell,Dorina Cadar,Anne McMunn et al.
Charlotte L Campbell et al.
Background: Intrinsic capacity (IC) is a new concept in the healthy aging field and has many operationalized definitions. In this study, we operationalized IC using item response theory in the English Longitudinal Study o...
Brain Proteome-Wide and Transcriptome-Wide Asso-ciation Studies, Bayesian Colocalization, and Mendelian Randomization Analyses Reveal Causal Genes of Parkinson's Disease [0.03%]
全脑蛋白质组关联分析、转录组关联分析、贝叶斯共定位和孟德尔随机化揭示帕金森病的致病基因
Siquan Zhou,Ye Tian,Xuejiao Song et al.
Siquan Zhou et al.
How genome-wide associated loci confer risk for Parkinson's disease is unclear. We aim to reveal causal genes through effects on brain proteins to provide new pathogenesis insights for Parkinson's disease. Proteome-wide and transcriptome-wi...
TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study [0.03%]
TNFR-1和GDF-15与居住在社区中的老年人的血浆神经丝轻链和前脑啡肽有关：MAPT研究的二次分析
Kelly Virecoulon Giudici,Philipe de Souto Barreto,Sophie Guyonnet et al.
Kelly Virecoulon Giudici et al.
There is growing evidence that cognitive decline can be affected by both nutritional aspects and inflammation. Plasma neurodegenerative biomarkers stand out as minimally invasive useful measures to monitor the potential risk of cognitive de...
Association Between Handgrip Strength and Type 2 Diabetes: A Prospective Cohort Study and Systematic Review With Meta-analysis [0.03%]
握力与二型糖尿病之间的关联：一项前瞻性队列研究和系统性回顾及元分析
Hongmei Wu,Yeqing Gu,Xuena Wang et al.
Hongmei Wu et al.
Background: Both absolute (kg) and relative (kg per kg of body weight) handgrip strength (HGS) have been used as indicators of HGS. Multiple studies have explored HGS associations with type 2 diabetes (T2DM); however, pro...
The Association of Peripheral and Central Olfaction With Frailty in Older Adults [0.03%]
外周和中枢嗅觉与老年人脆弱综合征的相关性研究
Nimesh V Nagururu,Isaac A Bernstein,Kristin Voegtline et al.
Nimesh V Nagururu et al.
Background: Olfactory impairment is increasingly recognized as a biomarker of frailty, but the relationship between olfactory subdomains that describe peripheral or central dysfunction and frailty remains unexplored. ...
Differential Associations Between Two Markers of Probable Sarcopenia and Continuous Orthostatic Hemodynamics in The Irish Longitudinal Study on Ageing [0.03%]
两种可能的 sarcopenia 标记物与爱尔兰老龄化纵向研究中的持续直立血液动力学之间的差异关联
Eoin Duggan,Caoileann H Murphy,Silvin P Knight et al.
Eoin Duggan et al.
Background: Sarcopenia and orthostatic hypotension are growing age-related health burdens associated with adverse outcomes, including falls. Despite a possible pathophysiological link, the association between the 2 disord...
Multimorbidity, 30-Day Readmissions, and Postdischarge Mortality Among Medicare Beneficiaries Using a New ICD-Coded Multimorbidity-Weighted Index [0.03%]
多重疾病，30天内再入院及ICD编码多重疾病权重指数评估中的医疗保险受益者的出院后死亡率
Melissa Y Wei
Melissa Y Wei
Background: Medically complex, disabled adults have high 30-day readmission rates. However, physical functioning is not routinely included in risk-adjustment models. We examined the association between multimorbidity with...
Clustering of Cardiometabolic Risk Factors and Dementia Incidence in Older Adults: A Cross-Country Comparison in England, the United States, and China [0.03%]
老年人心脑血管危险因素的聚集与痴呆发病率的跨国比较：英格兰、美国和中国的分析
Panagiota Kontari,Chris Fife-Schaw,Kimberley Smith
Panagiota Kontari
Background: There is mixed evidence for an association between cardiometabolic risk factors and dementia incidence. This study aimed to determine whether different latent classes of cardiometabolic conditions were associa...