Ethnicity and Parkinson's Disease: Motor and Nonmotor Features and Disease Progression in Latino Patients Living in Rural California [0.03%]
种族与帕金森病：生活在加州农村的拉美患者在运动和非运动特征及疾病进展方面的差异
Aline Duarte Folle,Marie E S Flores,Cynthia Kusters et al.
Aline Duarte Folle et al.
Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder among older adults worldwide. Currently, studies of PD progression rely primarily on White non-Latino (WNL) patients. Here, we comp...
Body Mass Index and Cognition: Associations Across Mid- to Late Life and Gender Differences [0.03%]
体质指数与认知力：中年到晚年内认知力的变化及性别差异关系
Breanna M Crane,Emma Nichols,Michelle C Carlson et al.
Breanna M Crane et al.
Background: Higher mid-life body mass index (BMI) is associated with lower late-life cognition. Associations between later-life BMI and cognition are less consistent; evidence suggests reverse causation may play a role. W...
Aging Is Associated With Impaired Postprandial Response of Skeletal Muscle Protein Synthesis to High-Intensity Muscle Contraction in Mice [0.03%]
衰老与小鼠骨骼肌蛋白质合成对高强度肌肉收缩的餐后反应受损有关
Satoru Ato,Hiroshi Matsunami,Riki Ogasawara
Satoru Ato
The purpose of this study was to investigate whether aging alters the effect of nutritional status on contraction-induced muscle protein metabolism. In an overnight fasted or fed states, the right gastrocnemius muscle of young (3 months) an...
Change in a Claims-Based Frailty Index, Mortality, and Health Care Costs in Medicare Beneficiaries [0.03%]
基于索赔的脆弱指数、死亡率和医疗保险受益人的医疗保健成本的变化
Sandra Miao Shi,Nessa Steinberg,Gahee Oh et al.
Sandra Miao Shi et al.
Background: A claims-based frailty index (CFI) allows measurement of frailty on a population scale. Our objective was to examine the association of changes in CFI over 12 months with mortality and Medicare costs. ...
Resveratrol Alleviates Inflammation and ER Stress Through SIRT1/NRF2 to Delay Ovarian Aging in a Short-Lived Fish [0.03%]
白藜芦醇通过SIRT1/NRF2通路减轻炎症和内质网应激延缓短寿命鱼的卵巢衰老
Hongyan Zhu,Xiaowen Li,Mengxue Qiao et al.
Hongyan Zhu et al.
Aging is a complex process in which the structure and function of various tissues and organs gradually decline with age, and ovarian aging affects the reproductive capacity of females and induces age-related diseases. Resveratrol, a natural...
Decrease in Gait Speed Over Time Is Associated With Increase in Number of Depression Symptoms in Older Adults With Type 2 Diabetes [0.03%]
步速的下降与二型糖尿病老年人抑郁症症状数量的增加有关
Inbar Lavie,Michal Schnaider Beeri,Yonathan Schwartz et al.
Inbar Lavie et al.
Background: We examined the cross-sectional and longitudinal relationships of motor functions with depression in older adults with type 2 diabetes (T2D). ...
X Chromosome Factor Kdm6a Enhances Cognition Independent of Its Demethylase Function in the Aging XY Male Brain [0.03%]
X染色体因子Kdm6a通过其去甲基化功能以外的方式在老化雄性大脑中增强认知能力
Cayce K Shaw,Samira Abdulai-Saiku,Francesca Marino et al.
Cayce K Shaw et al.
Males exhibit shorter life span and more cognitive deficits, in the absence of dementia, in aging human populations. In mammals, the X chromosome is enriched for neural genes and is a major source of biologic sex difference, in part, becaus...
Canine Model of Human Frailty: Adaptation of a Frailty Phenotype in Older Dogs [0.03%]
人类脆弱性的犬类模型：老年狗身上适应的脆弱性表型
Romane Lemaréchal,Sara Hoummady,Inès Barthélémy et al.
Romane Lemaréchal et al.
Frailty is a clinical presentation resulting from age-related cumulative declines in several physiological systems. The aim of this study was to adapt the concept of frailty to the domestic dog, as a model for frailty research, by character...
Social Isolation, Sleep Disturbance, and Cognitive Functioning (HRS): A Longitudinal Mediation Study [0.03%]
社会隔离、睡眠障碍和认知功能（HRS）：纵向中介研究
Xiang Qi,Yaolin Pei,Susan K Malone et al.
Xiang Qi et al.
Background: Social isolation is prevalent and associated with dementia, yet the directionality and mechanisms are less understood. This study examined the association between social isolation and cognitive functioning and...