Racial and Ethnic Trajectories of Sleep Disturbances: Variations by Age and Cohort [0.03%]
种族和族裔背景对睡眠障碍的影响：年龄与世代的差异
Jen-Hao Chen
Jen-Hao Chen
Background: The racial and ethnic differences in trajectories of sleep disturbances in later life are crucial for addressing health disparities, but are not well understood. This study examines (a) how trajectories of sle...
Adverse Childhood Experiences and Poor Sleep Quality in Older Adults: The Influence of Emotion Regulation [0.03%]
童年逆境与老年人的睡眠质量差：情绪调节的影响
Julia L Sheffler,Valeria Burchard,Scott Pickett
Julia L Sheffler
Background: Adverse childhood experiences (ACEs) are associated with sleep impairment across the life span, but little is known about modifiable factors that may ameliorate this relationship, such as adaptive emotion regu...
Deprescribing Anticholinergic and Sedative Drugs to Reduce Polypharmacy in Frail Older Adults Living in the Community: A Randomized Controlled Trial [0.03%]
撤减 frail older adults 所用的抗胆碱能药物和镇静药以减少多重用药：随机对照试验
Hamish Jamieson,Prasad S Nishtala,Hans Ulrich Bergler et al.
Hamish Jamieson et al.
Background: Polypharmacy is associated with poor outcomes in older adults. Targeted deprescribing of anticholinergic and sedative medications may improve health outcomes for frail older adults. Our pharmacist-led deprescr...
Mortality Associations With DNA Methylation-Based Biological Aging and Physical Functioning Measures Across a 20-Year Follow-up Period [0.03%]
基于DNA甲基化生物衰老和20年随访期间的体能测量指标的死亡率关联研究
Tiina Föhr,Katja Waller,Anne Viljanen et al.
Tiina Föhr et al.
Background: Measures of biological aging range from DNA methylation (DNAm)-based estimates to measures of physical abilities. The purpose of this study was to compare DNAm- and physical functioning-based measures of biolo...
Prevalence of Dementia and Cognitive Impairment No Dementia in a Large and Diverse Nationally Representative Sample: The ELSI-Brazil Study [0.03%]
大型多样化全国代表性样本中的痴呆和非痴呆认知障碍的患病率：ELSI-巴西研究
Laiss Bertola,Claudia Kimie Suemoto,Márlon Juliano Romero Aliberti et al.
Laiss Bertola et al.
Background: Approximately 77% of older adults with dementia in Brazil have not been diagnosed, indicating a major public health issue. Previous epidemiological dementia studies in Brazil were based on data from 1 geopolit...
Evaluation of Associations of Growth Differentiation Factor-11, Growth Differentiation Factor-8, and Their Binding Proteins Follistatin and Follistatin-Like Protein-3 With Dementia and Cognition [0.03%]
生长分化因子-11、生长分化因子-8及其结合蛋白卵泡刺激素和类似蛋白-3与痴呆和认知的关系评估
Anne B Newman,Sheena Patel,Jorge R Kizer et al.
Anne B Newman et al.
Background: Studies using heterochronic parabiosis discovered that circulating factors mediate brain aging in animal models. Methods: W...
Association of Subjective and Objective Measures of Sleep With Gut Microbiota Composition and Diversity in Older Men: The Osteoporotic Fractures in Men Study [0.03%]
老年男性的主观和客观睡眠测量值与肠道微生物群组成和多样性之间的关联：来自男性骨质疏松性骨折研究的发现
Mehrbod Estaki,Lisa Langsetmo,Michelle Shardell et al.
Mehrbod Estaki et al.
Background: Growing evidence suggests bidirectional links between gut microbiota and sleep quality as shared contributors to health. Little is known about the relationship between microbiota and sleep among older persons....
Domains of Sedentary Behavior and Cognitive Function: The Health, Aging, and Body Composition Study, 1999/2000 to 2006/2007 [0.03%]
久坐行为领域与认知功能：来自健康、老龄化和身体构成研究，1999/2000年至2006/2007年的数据
Laura Major,Eleanor M Simonsick,Melissa A Napolitano et al.
Laura Major et al.
Background: This study examines the relationship between various domains of sedentary behavior and subsequent cognitive function to evaluate whether different sedentary activities have specific associations with future co...
Dyskeratosis Congenita Links Telomere Attrition to Age-Related Systemic Energetics [0.03%]
先天性角化不良综合症将端粒损耗与年龄相关全身能量学联系起来
Emma Naomi James,Virag Sagi-Kiss,Mark Bennett et al.
Emma Naomi James et al.
The underlying mechanisms of plasma metabolite signatures of human aging and age-related diseases are not clear but telomere attrition and dysfunction are central to both. Dyskeratosis congenita (DC) is associated with mutations in the telo...