Diagnostic value of saccades in mild cognitive impairment (MCI): a community-based study [0.03%]
社区获得性轻度认知障碍(MCI)诊断中扫视检测的价值研究
Leihao Sha,Hua Li,Anjiao Peng et al.
Leihao Sha et al.
Background: Accurate diagnosis and assessment of mild cognitive impairment (MCI) are essential. The efficacy of saccades in the detection of MCI lacks validation through large-scale clinical trials. ...
Macronutrient content and quality, and risk of multimorbidity in the UK biobank [0.03%]
英国生物样本库中宏量营养素的含量和质量及其与多发病风险的关系
Aitana Vázquez-Fernández,Humberto Yévenes-Briones,Ana Baylin et al.
Aitana Vázquez-Fernández et al.
Background: Multimorbidity is a major determinant of lifespan in older adults. We aimed to examine the association between overall, healthy and unhealthy Low-Carbohydrate diets (LCD) and Low-Fat diets (LFD) with the incid...
The Dynamic Trends and Causal Effects of Social Participation and Cognitive Function Among Middle-Aged and Older Adults: A Longitudinal Study in China [0.03%]
中国中老年人社会参与与认知功能的动态趋势及因果效应：一项纵向研究
Lin Sun,Jingru Wang,Yuting Kang et al.
Lin Sun et al.
Background: The aim of this study was to explore the developmental trajectories of social participation and cognitive function, as well as their interaction. ...
TITLE: Frailty, grip strength, blood-based biomarkers of neuropathology and incident dementia: a 17-year longitudinal population study [0.03%]
肌力减弱、血液神经病理生物标志物与新发痴呆症的相关性：一项为期17年的纵向人群研究
Johannes C Michaelian,Kira Trares,Joshua Stevenson-Hoare et al.
Johannes C Michaelian et al.
Background: While previous research has demonstrated that frailty is associated with increased dementia risk over time, large multi-decade prospective population-based cohort studies remain limited. Furthermore, the assoc...
Liraglutide improves cognitive function by reducing amyloid-beta peptide accumulation and inhibiting inflammation in 5 × FAD mice [0.03%]
利拉鲁肽通过减少淀粉样蛋白-β沉积和抑制炎症改善5×FAD小鼠认知功能
Liqin Qi,Lijing Lin,Jiaping Zheng et al.
Liqin Qi et al.
Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by progressive memory decline. The increasing prevalence of AD has attracted considerable attention globally. The glucagon-like peptide-1 analog,...
Transcriptomic and experimental validation identifies SOX6 and LDLRAD3 as key factors in vascular dementia [0.03%]
转录组和实验验证识别出SOX6和LDLRAD3在血管性痴呆中的重要作用
Jinrong Hu,Xia Yang,Wen Lei et al.
Jinrong Hu et al.
Vascular dementia (VaD) is a leading cause of cognitive decline, yet its underlying molecular mechanisms remain incompletely understood. This study aims to investigate the alterations associated with VaD in neuronal and endothelial cells by...
Benzodiazepine Exposure and 6-Month Mortality in Older Adults Post-Hospitalization: Time to Consider Deprescribing? [0.03%]
老年人出院后的苯二氮平暴露与半年死亡率：是时候考虑减少用药了吗？
Federico Bellelli,Maria Cristina Ferrara,Alice Margherita Ornago et al.
Federico Bellelli et al.
Background: Benzodiazepines (BZDs) are commonly used in older populations despite their association with multiple adverse outcomes. However, the impact of continuing versus deprescribing BZDs during hospitalization on sho...
Sleep Quality as a Modifier of Plasma pTau217 and GFAP Associations with Cognitive Function [0.03%]
睡眠质量作为血浆pTau217和GFAP与认知功能关联的修饰因素
Ramkrishna K Singh,Semere Bekena,Yiqi Zhu et al.
Ramkrishna K Singh et al.
Background: Plasma biomarkers, such as neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), phosphorylated tau (pTau217), and total tau (tTau), are associated with cognitive decline. However, the role ...
Bidirectional Relationships between Pain and Alcohol Use among Older Adults: A Scoping Review [0.03%]
老年人疼痛与饮酒的双向关系：综述研究
Lisa R Larowe,Heily Chavez Granados,Lisa L Philpotts et al.
Lisa R Larowe et al.
Background: Pain and alcohol use are highly prevalent and frequently co-occur among older adults. An established reciprocal model suggests that pain and alcohol use interact in the manner of a positive feedback loop. Howe...
Preclinical Mobility Limitations Amongst Community Dwelling Older Adults Using the National Health and Aging Trends Study [0.03%]
基于全国健康和老龄化趋势研究的社区老年人前期行动能力限制状况
Pallavi Tyagi,Luisa Franzini,Jie Chen
Pallavi Tyagi
Background: Preclinical Mobility Limitations (PCML) represent an early transitional stage in which individuals compensate for functional decline, yet do not exhibit overt disability. Recognition of PCML may identify indiv...