Impact of Multidomain Lifestyle Intervention on Dynamics of Cognitive Frailty: Post-hoc Analysis of the FINGER Trial [0.03%]
多领域生活方式干预对认知脆弱动态的影响：FINGER试验的事后分析
Johanna Pöyhönen,Hanna-Maria Roitto,Jenni Lehtisalo et al.
Johanna Pöyhönen et al.
Background: Cognitive frailty (CF), a condition with physical frailty and mild cognitive impairment (MCI) without dementia, is potentially reversible and linked to adverse outcomes. We aimed to investigate the impact of a...
Associations between the triglyceride glucose-body roundness index and frailty trajectory in populations with Cardiovascular-Kidney-Metabolic syndrome: A nationwide prospective cohort study [0.03%]
心血管-肾脏-代谢综合征人群中的甘油三酯葡萄糖-体圆度指数与衰弱轨迹的关系：一项全国性前瞻性队列研究
Zhongmin Fu,Shulin Song,Yan Ji et al.
Zhongmin Fu et al.
Background: Frailty is a key intervention target for older adults with cardiovascular-kidney-metabolic (CKM) syndrome. Evidence suggests that the triglyceride glucose (TyG) index and body roundness index (BRI) are associa...
Associations between osteosarcopenia and cognitive function in community-dwelling older adults: evidence from a US cohort [0.03%]
美国社区老年人群队列中骨肌减少与认知功能的关系证据
Konstantinos Prokopidis,Stefano Cacciatore,Nicola Veronese et al.
Konstantinos Prokopidis et al.
Background: This study investigated domain-specific associations between osteosarcopenia, defined as the coexistence of osteopenia or osteoporosis with low handgrip strength (HGS), and cognitive function in a cohort of ol...
The nonlinear U-shaped association between vitamin D deficiency and biological aging acceleration is enhanced in individuals with higher inflammation levels [0.03%]
维生素D缺乏与生物衰老加速之间的非线性U形关联在炎症水平较高的人群中增强
Jatupol Kositsawat,George A Kuchel,Kelin Zhong et al.
Jatupol Kositsawat et al.
Background: Aging is multifactorial, yet aging research emphasizes independent risk factors. Endocrine and inflammatory factors have been linked to opposing and synergistic associations with suboptimal aging. ...
Insomnia Symptoms, Sleep Duration and Risk of Falls in Older Adult Women: Findings from the Study of Women's Health Across the Nation [0.03%]
绝经期女性失眠症状、睡眠时长与跌倒风险的关系：美国妇女健康跨断面研究结果
Jillian S Baker,Michelle M Hood,Leslie M Swanson et al.
Jillian S Baker et al.
Background: As the leading cause of injury and injury-related death for older adults in the United States, falls can be consequential for function and mortality but are preventable. Sleep may be a modifiable risk factor f...
High-fat diet exacerbates skeletal muscle mass loss via Nrf2/Prdx6 pathway in sarcopenic obesity mice [0.03%]
高脂饮食通过Nrf2/Prdx6信号通路加剧恶病质型肥胖小鼠的肌肉萎缩作用
Danni Wang,Xinyue Zheng,Yang Zhu et al.
Danni Wang et al.
Sarcopenic obesity (SO), a dual condition characterized by the coexistence of sarcopenia and obesity, elevates the risk of metabolic disorders, disability, and mortality to magnitudes exceeding the combined risks of both conditions individu...
Personality Traits Influence Frailty in Older Adults through Health Behaviours and Psychosocial Resources [0.03%]
人格特征通过健康行为和心理社会资源影响老年人的衰弱状态
Silvia Vittoria Cracas,Rose Anne Kenny,Siobhan Scarlett et al.
Silvia Vittoria Cracas et al.
Background: Frailty is a critical public health issue in aging populations, linked to increased disability, hospitalization, and mortality. While biological and clinical risk factors are well established, less is known ab...
Neither caloric nor protein restriction increases the male lifespan of outbred short-lived fish [0.03%]
卡路里限制或蛋白质限制都不能增加短命鱼的雄性寿命
Jakub Žák,Martin Reichard Prof
Jakub Žák
Laboratory inbred strains respond strongly to dietary restriction (DR), whereas genetically diverse populations may not experience comparable benefits. The exceptionally short-lived fish, Nothobranchius furzeri, offers several genetically d...
Interplay of Accelerated Biological Aging, Lifestyle Factors, and Genetic Susceptibility in Cognitive Function: A Community Study [0.03%]
加速生物学老化、生活方式因素和遗传易感性在认知功能中的相互作用：一项社区研究
Tianpei Ma,Xin Chen,Qingwen Zhao et al.
Tianpei Ma et al.
Cognitive impairment is a significant health concern in aging populations, but the interplay between biological aging, lifestyle factors, and genetic susceptibility remains unclear. This study examined whether accelerated biological aging i...
Gait variability predicts falls in older adults with multiple sclerosis [0.03%]
步态变化与老年多发性硬化症患者的跌倒风险预测关系
Manuel E Hernandez,Robert W Motl,Frederick W Foley et al.
Manuel E Hernandez et al.
Background: Falls and gait variability are prevalent in older adults with and without multiple sclerosis. Gait variability has been associated with an increased likelihood of reporting falls in older adults, yet its predi...