Physical activity offsets air-pollution-related cognitive decline: a retrospective cohort study based on CHARLS [0.03%]
基于CHARLS的回顾性队列研究：体力活动抵消了空气污染相关的认知衰退
Zhi Yu,Zhefu Jiang,Yifan Feng et al.
Zhi Yu et al.
Background: This study examined whether physical activity (PA) buffers air-pollution-related cognitive decline in middle-aged and older adults, quantified the dose-response relationship, and derived pollution-specific PA ...
Cross-sectional and Longitudinal Associations between Testosterone and Cognitive Performance in Older People: Results of the Berlin Aging Study II (BASE-II) [0.03%]
睾丸激素与认知表现之间的横断面和纵向关联——柏林老年研究Ⅱ的结论(BASE-Ⅱ)
Vivien Bahr,Hannah Schmid,Valentin Max Vetter et al.
Vivien Bahr et al.
Background: Age-related declines in gonadal and cognitive function are commonly observed, but their relationship is still not completely understood. Metho...
Quantifying the Population-Level Impact of Insomnia on Dementia Among Older Adults in the United States [0.03%]
量化失眠对美国老年人痴呆症的群体影响
Yuqian Lin,Fei Wu,Yuhan Wu et al.
Yuqian Lin et al.
Background: Insomnia has been identified as a plausible modifiable risk factor for dementia. Quantifying its population-level impact may inform strategies to reduce dementia risk among older adults in the United States. ...
Phenoage and Phenoageaccel Do Not Outperform Chronological Age in Predicting Physical Performance Decline or Mortality in Community-Dwelling Older Adults [0.03%]
表型年龄和加速表型年龄不能优于日历年龄预测社区居住老年人的体能下降或死亡风险
Maria Serena Iuorio,Antonio De Vincentis,Diana Lelli et al.
Maria Serena Iuorio et al.
Background: Chronological age inadequately captures inter-individual variability in aging-related functional decline. Biological age metrics such as PhenoAge and PhenoAgeAccel, based on clinical biomarkers, have shown ass...
Association of cumulative deficit frailty with brain age and Alzheimer's disease-related brain structure starting in late middle age [0.03%]
累积缺陷虚弱与晚年中年期开始的脑年龄以及阿尔茨海默病相关脑结构的关系
Jack F V Hunt,Erik J Buchholz,Carol E Franz et al.
Jack F V Hunt et al.
Background: Cumulative deficit frailty (CDF) is a syndrome characterized by the accumulation of negative physical, functional and psychosocial insults. Accumulation of CDF and changes in brain structure both occur during ...
Ines Sturmlechner,Sarah A Ashiqueali,Hélène Martini et al.
Ines Sturmlechner et al.
Geroscience research benefits from interdisciplinary approaches, team science, and collaborations, which collectively facilitate the discovery of aging mechanisms and their translation into tangible, clinical interventions. Since its incept...
Benjamin R Harrison,Joshua M Akey,Noah Snyder-Mackler et al.
Benjamin R Harrison et al.
There is growing interest in the use of molecular features as predictors of age, age-related disease risk and mortality. A major shortcoming of this field, however, is the lack of suitable translational research models to identify and under...
Pain prevalence and pain management at the end of life: Regional and urban-rural differences from a national-representative survey of chinese older adults [0.03%]
中国老年人生命终末期的疼痛患病率及镇痛状况：来自全国大样本人群调查的结果及城乡差异分析
Yaolin Pei,Xiang Qi,Zexi Zhou et al.
Yaolin Pei et al.
Background: Effective pain management is essential for enhancing quality of life at the end of life. However, challenges persist globally, particularly in China, where palliative care remains underdeveloped. This study in...
Association of neurodevelopmental conditions with Alzheimer's disease and related dementias and Parkinson's disease [0.03%]
神经发育障碍与阿尔茨海默病和其他痴呆症及帕金森病的关系
Jessica E Rast,Andrea L Rosso,Bryan D James et al.
Jessica E Rast et al.
Background: Neurodevelopmental conditions (NDC), including attention deficit/hyperactivity disorder (ADHD) and autism, are associated with increased rates of neurodegenerative diseases, including Alzheimer's disease and r...
ICEBERG emergency room screening tool for early adverse outcome prediction in older patients admitted to acute care: a multi-center study [0.03%]
ICEBERG急性护理老年患者不良预后早期预测急诊筛查工具的多中心研究
Heike A Bischoff-Ferrari,Dai-Hua Tsai,Melanie Kistler-Fischbacher et al.
Heike A Bischoff-Ferrari et al.
Background: The ICEBERG tool was initially validated in two small pilot studies to address the lack of a comprehensive geriatric screening tool in emergency settings. The present study builds on the second pilot study and...