Can Infections Drive Frailty? Insights from the Baltimore Longitudinal Study of Aging [0.03%]
感染与衰弱的关系：来自巴尔的摩老龄化纵向研究的启示
Francesco Saverio Ragusa,Toshiko Tanaka,Michael R Duggan et al.
Francesco Saverio Ragusa et al.
Background: Frail older people have elevated risk of developing infection. Whether a history of infections is associated with frailty and mortality has not been fully explored. This study investigates the associations bet...
Rethinking Immune Studies: Population-Level Immune Variations and the Path Forward [0.03%]
反思免疫学研究：人群水平的免疫差异及未来方向
Micah R Hysong,Aylin Memili,Joseph A Delaney et al.
Micah R Hysong et al.
Shifts in immune cell proportions underlie disease progression and immunotherapy response, positioning them as promising diagnostic biomarkers and therapeutic targets. However, these shifts also occur naturally across the lifespan and vary ...
Oxidative Stress Biomarkers as Predictors of Aging and Age-Related Diseases [0.03%]
氧化应激生物标志物在衰老及相关疾病中的预测作用
Yogesh Kumar,Anuja Pant,Somu Yadav et al.
Yogesh Kumar et al.
Oxidative Stress (OS) is a major feature of aging and is first brought on when the generation of Reactive Oxygen Species (ROS) surpasses the capacity of antioxidant defenses to neutralize them. Long-term exposure to ROS gradually damages vi...
Associations and Interaction Effects of Socioeconomic, Lifestyle, and Genetic Factors on Intrinsic Capacity [0.03%]
社会经济、生活方式和遗传因素与固有能力的相关性和交互作用效应
Melkamu Bedimo Beyene,Renuka Visvanathan,Robel Alemu et al.
Melkamu Bedimo Beyene et al.
Intrinsic capacity (IC), which reflects the combined physical and mental reserve of an individual, is a key indicator of healthy ageing. While genetic and environmental factors influence IC, the interaction effects between them remain poorl...
Plasma Metabolomic Profiling and Functional Disability in Older Adults [0.03%]
老年人血浆代谢组学特征与功能残疾的关系研究
Andrés Pombo-Jiménez,Damián González-Beltrán,Humberto Yévenes-Briones et al.
Andrés Pombo-Jiménez et al.
Background: Functional disability is a major public health concern in older adults, predicting adverse outcomes such as hospitalization, institutionalization, and mortality. While previous studies have linked metabolomic ...
Leveraging Precision Medicine Analytics to Optimize Inflammation Reduction and Enhance Physical Function in Older Adults [0.03%]
精准医学分析在老年人群中的应用：优化抗炎治疗以增强身体机能
Sonum D Tharwani,David H Lynch,Dominic E Boccaccio et al.
Sonum D Tharwani et al.
Background: Chronic inflammation in older adults is a key contributor to functional decline and mortality. Although anti-inflammatory medications have shown limited success in improving physical function, emerging targete...
Avoiding trip- and slip-hazards in suburban footpaths by older adults: An immersive virtual reality experiment [0.03%]
老年人郊区人行道绊倒和滑倒危险的规避研究：基于沉浸式虚拟现实的实验
Yixuan He,Juno Kim,Matthew A Brodie et al.
Yixuan He et al.
Background: Older people often fall due to trips and slips in daily life. This study aimed to elucidate the mechanisms of trip- and slip-hazard avoidance while walking through an immersive virtual reality suburban footpat...
Extracellular Vesicle-Derived Mitochondrial Genes as Potential Biomarkers for Brain Aging in Human [0.03%]
人类脑衰老的外泌体衍生线粒体基因潜在生物标志物研究
Qian Yu,Shuyi Yu,Hang Chen et al.
Qian Yu et al.
Aging significantly impacts brain function, and identifying reliable biomarkers for early detection of age-related neurodegeneration is crucial for improving diagnosis and treatment outcomes. This proof-of-principle study aims to evaluate t...
Early Life Adversity, Educational Attainment, and Cardiometabolic Risk Among Middle-Aged and Older Adults in the United States [0.03%]
美国中老年人的心血管代谢风险与早年逆境和教育程度的关系
Catherine García,Ying Xu,Morgan A Parella
Catherine García
Background: Early life adversity (ELA) is a known contributor to physiological dysregulation and chronic disease in adulthood. However, less is known about how specific ELA domains influence cardiometabolic dysregulation ...
The influence of multiple air pollutants on sarcopenia progression: A multi-state analysis in a prospective cohort [0.03%]
多种空气污染物对少肌症进展的影响：前瞻性队列中的多状态分析
Ni Sang,Xingyue Dai,Qiaoling Yang et al.
Ni Sang et al.
Background: Air pollution's influence on sarcopenia progression remains insufficiently studied. Methods: Using the UK Biobank cohort, w...