Harmonization of self-reported and performance-based measures of vision using inverse probability weighting: an example using vision and depression in NHATS, CLSA, and LASI [0.03%]
基于逆概率加权的视力自报与客观测查的一致性分析——以NHATS、CLSA和LASI为例
Melissa Li,Dylan P Thibault,Lindsey B De Lott et al.
Melissa Li et al.
Background: Visual impairment is a potential risk factor for depression and other outcomes in older adults. In population-based studies, vision can be measured using self-report or performance-based visual acuity, but epi...
"I had eyes on me to help me": a qualitative descriptive study on trust in passive monitoring systems among older adults with mild cognitive impairment [0.03%]
“我有人照看我”: 老年期轻度认知障碍患者的被动监测系统信任定性描述研究
Oonjee Oh,Sean Harrison,Justine S Sefcik et al.
Oonjee Oh et al.
Background: Passive monitoring can support aging in place for older adults with mild cognitive impairment (MCI). Yet, their trust in the technology is crucial as the devices are installed in their homes, collecting data t...
RPS14 as an aging-related biomarker for early-onset alterations of testicular senescence-associated genes in spermatogenic dysfunction at childbearing age [0.03%]
RPS14作为睾丸衰老相关基因组年轻型改变的新型生物标志物及其在生育年龄群体少弱精子症中的作用研究
Fan Dong,Ping Ping,Si-Qi Wang et al.
Fan Dong et al.
The early-onset transcriptional phenotype of senescence has been revealed in spermatogenic dysfunctional testes of patients at childbearing age. However, limited studies have reported the biomarker and function of testicular senescence-asso...
Social isolation and functional impairment score trajectories in a diverse cohort of middle-aged and older adults in Northern California [0.03%]
社会孤立与中老年人功能损害评分轨迹：加利福尼亚北部多样人群队列研究
L Paloma Rojas-Saunero,Ryo Ikesu,Yixuan Zhou et al.
L Paloma Rojas-Saunero et al.
Background: Social isolation is a key social determinant of health, yet research on its relationship with functional impairment is limited. We compared functional impairment score trajectories of older adults who experien...
Sleep, Metabolites, and Global Cognition: A Mediation Analysis of Plasma Metabolic Profiles in the West China Health and Aging Cohort [0.03%]
睡眠、代谢产物和全球认知：西中国健康老龄化队列中血浆代谢谱的中介分析
Xueyao Wu,Qingwen Zhao,Xingyu Zhang et al.
Xueyao Wu et al.
Background: Growing evidence connects sleep disorders with cognitive impairment in older adults, though underlying biological mechanisms remain unclear. We investigated how plasma metabolic profiles mediate the relationsh...
Preoperative plasma glial fibrillary acidic protein and postoperative delirium in older adults [0.03%]
老年人大手术前血浆胶质纤维酸性蛋白与术后谵妄的关系
Julianna Liu,Steven E Arnold,Pia Kivisäkk et al.
Julianna Liu et al.
Background: Delirium is a common complication of hospitalization with poor outcomes, but its underlying pathophysiology is poorly understood. We investigated the association of preoperative glial fibrillary acidic protein...
Calcium chloride supplementation promotes longevity in Caenorhabditis elegans via a CKK-1 and CMK-1-dependent UNC-43/DAF-16 signaling mechanism [0.03%]
氯化钙补充通过CKK-1和CMK-1依赖的UNC-43 / DAF-16信号传导机制促进秀丽隐杆线虫寿命延长
Che-Hsu Chin,Nae-Cherng Yang
Che-Hsu Chin
Calcium chloride can be used as a food additive and in medicine. The intake of calcium chloride can elevate the intracellular Ca2+ level, which subsequently activates the downstream proteins in the Ca2+/calmodulin-dependent protein kinase (...
Exploring the Association between Epigenetic Age and Intensive Care Unit Delirium: A Pilot Feasibility Study [0.03%]
表观遗传学年龄与重症监护病房谵妄相关性的探索性研究
Sikandar H Khan,Sara C Lahue,Anthony J Perkins et al.
Sikandar H Khan et al.
Epigenetic clocks (EC) measuring epigenetic age (EA) and epigenetic age acceleration (EAA) are biomarkers of biological aging, but their association with intensive care unit (ICU) delirium remains underexplored. This is a pilot study utiliz...
Development and Evaluation of a Cross-Study Comparable Frailty Index based on Item Response Theory: Insights from Three Prospective Cohorts [0.03%]
基于项目反应理论的跨研究可比脆弱性指数的开发与评估：来自三项前瞻性队列研究的启示
Shuai Liu,Guangquan Ran,Yan Wang et al.
Shuai Liu et al.
Background: The Frailty Index of Accumulative Deficits (FI-CD) is a key predictor of adverse health outcomes in older adults, but its utility for cross-study comparisons is limited due to assumptions of item homogeneity. ...
Sex Differences in Genetic Modifiers of Traumatic Brain Injury and Late-Life Cognitive Decline: The Cache County Study [0.03%]
性别差异影响创伤性脑损伤和晚年认知衰退的遗传修饰因子——来自Cache County研究的证据
Mikaela A Drewel,Sarah Schwartz,Gail B Rattinger et al.
Mikaela A Drewel et al.
Traumatic brain injury (TBI) is a well-recognized risk factor for late-life cognitive decline. However, few studies have examined individual differences in sex and genetics, which may modify risk. We examined sex differences in gene-TBI int...