Roles of genetic predisposition and mediation of biological age acceleration in the association between air pollution and dementia [0.03%]
遗传易感性和生物年龄加速介导在空气污染与痴呆关联中的作用
Zhou Jiang,Yu Yan,Jike Qi et al.
Zhou Jiang et al.
Background: Air pollution exposure (both individual and joint) is associated with dementia, but its relation to early-onset dementia (EOD) and late-onset dementia (LOD) remains inconclusive. Meanwhile, the modification by...
Age-Related Cognitive Decline and Dementia: Interface of Microbiome-Immune-Neuronal Interactions [0.03%]
与年龄相关的认知能力下降和痴呆症：微生物群-免疫-神经相互作用的界面
Santosh Kumar Prajapati,Shalini Jain,Hariom Yadav
Santosh Kumar Prajapati
The microbiome plays a critical role in both promoting human health and contributing to diseases. Multiple emerging evidence shows that it contributes to aging and cognitive decline; however, the mechanisms are not fully understood. Changes...
Predictors of bi-directional transitions from mild cognitive impairment in a diverse cohort [0.03%]
在多样化的队列中预测轻度认知障碍的双向转变的因素
Mitzi M Gonzales,Roman Fernandez,Sarah Kremen et al.
Mitzi M Gonzales et al.
Trajectories following a diagnosis of mild cognitive impairment (MCI) are varied and may fluctuate over time. Among diverse ethnic and racial groups, social factors, medical comorbidities, and biases in assessment procedures may contribute ...
Expanding Geroscience to Vulnerable Populations in mid-late life: Medicaid home- and community-based service users and formerly incarcerated individuals [0.03%]
将老年科学扩展到中晚期生活的脆弱群体：使用医疗补助家庭和社区服务的人以及曾被监禁的个人
Richard H Fortinsky,Iman M Al-Naggar,Lisa C Barry et al.
Richard H Fortinsky et al.
A wide range of geroscience-guided interventions, or gerotherapeutics, including repurposed drugs, natural products, and lifestyle changes are now being tested in small-scale proof-of-concept studies. If successful, these efforts may help m...
Ferroptosis activation contributes to kidney aging in mice by promoting tubular cell senescence [0.03%]
铁死亡的激活通过促进管细胞衰老导致小鼠肾脏老化
Zheng Wang,Yue Dai,Rui Jin et al.
Zheng Wang et al.
Kidney aging is the strongest independent risk factor for chronic kidney disease. Ferroptosis, a recently discovered form of cell death mediated by iron overload and lipid peroxidation accumulation, has an unclear role in kidney aging. To d...
Returning individualized wearable sensor results to older adult research participants: A pilot study [0.03%]
向老年受试者反馈个体化的可穿戴传感器结果：一项初步研究
Shelby L Bachman,Krista S Leonard-Corzo,Jennifer M Blankenship et al.
Shelby L Bachman et al.
Background: Wearable sensors that monitor physical behaviors are increasingly adopted in clinical research. Older adult research participants have expressed interest in tracking and receiving feedback on their physical be...
Comparing step counting algorithms for high-resolution wrist accelerometry data in older adults in the ARIC study [0.03%]
ARIC研究中高分辨率腕部加速度计数据的步数计算算法比较——针对老年人群
Sunan Gao,Xinkai Zhou,Lily Koffman et al.
Sunan Gao et al.
Background: Step counting from wrist accelerometry data is widely used in physical activity research and practice. While several open-source algorithms can estimate steps from high-resolution accelerometry data, there is ...
Comment on: "All-Cause Mortality and Cause-Specific Death in U.S. Long-Lived Siblings: Data From the Long Life Family Study" [0.03%]
评论：“美国高寿兄弟姐妹们的死因别和全部原因引起的死亡率：长寿家庭研究的数据”
Ugo Lucca,Mauro Tettamanti
Ugo Lucca
Association of plasma fatty acid profile with trajectory of multimorbidity and mortality: A community-based longitudinal study [0.03%]
血浆脂肪酸谱与多病共存及死亡率轨迹的关联性：基于社区的纵向研究
Yang Li,Jiao Wang,Yuyang Miao et al.
Yang Li et al.
Background: Plasma fatty acids have been linked to various chronic diseases and mortality, but the extent to which fatty acids are associated with the trajectory of multimorbidity remains unclear. We investigated the asso...
Multivariate Profiling of Physical Resilience in Older Adults After Total Knee Replacement Surgery: Results from a Prospective Observational Study [0.03%]
全膝置换术后老年人身体恢复的多变量分析：来自一项前瞻性观察研究的结果
Qian-Li Xue,Thomas Laskow,Mallak K Alzahrani et al.
Qian-Li Xue et al.
Background: As individuals age, their ability to cope with and recovering from health challenges becomes vital for maintaining independence and quality of life. This study aims to develop a multivariate phenotype of physi...