Benefits of Oral Nitrite Supplementation on Mitochondrial Respiration and Physical Function In Older Adults [0.03%]
口服一氧化氮前体补充剂对老年人线粒体呼吸和物理功能的益处
Daniel E Forman,Subashan Perera,Sruti Shiva et al.
Daniel E Forman et al.
Background: Age-associated decline in mitochondrial oxidative capacity is associated with increased risk of disease, frailty, and disability. Oral nitrite and nitrate supplementation have been demonstrated to improve mito...
Associations of unmet dental care needs due to cost with incident cardiovascular disease and dementia: a prospective study in the All of Us cohort [0.03%]
基于成本的未满足牙科护理需求与心血管疾病和痴呆症发病率之间的前瞻性研究：来自“全民参与”队列的数据分析
Mabeline Velez,Peter T Buto,Anna M Pederson et al.
Mabeline Velez et al.
Background: Poor oral health among older adults may contribute to cardiovascular and dementia risk via systemic inflammation and cardiometabolic comorbidities. Financial constraints are a major driver of unmet dental care...
Are Aging Clocks Based on Routine Clinical Indicators Trustworthy and Applicable? A Systematic Review and Critical Appraisal [0.03%]
基于常规临床指标的老化时钟可靠且适用吗？系统评价和批判性评估
Jiajia Zhang,Jie Hu,Yinyan Gao et al.
Jiajia Zhang et al.
Aging clocks based on routine clinical indicators have emerged as a cost-effective tool for assessing biological age. This systematic review aims to summarize the characteristics and critically appraise these available aging clocks. Studies...
The relative effects of different exercise modes on physical and metabolic health in older adults: A network meta-analysis [0.03%]
不同运动模式对老年人身心代谢健康影响的网络meta分析
Yuan Jiuchen,Fanghui L I,Shusheng Shi et al.
Yuan Jiuchen et al.
Background: Multiple exercise modalities are recommended for older adults, yet their comparative effectiveness remains uncertain. We conducted a Bayesian network meta-analysis of randomized trials to compare common exerci...
Socioeconomic and clinical predictors of all-cause mortality among older adults in India from 2017-2024: the importance of cognitive health and dementia [0.03%]
印度2017-2024年老年人全因死亡率的社会经济和临床预测因素：认知健康和痴呆的重要性
Emma Nichols,Sharmistha Dey,Pranali Khobragade et al.
Emma Nichols et al.
Background: Characterizing the correlates of adult mortality can lend insights into the factors associated with consequential health outcomes among older adults. In India, the importance of adult mortality has grown given...
Particulate Air Pollution and Post-Discharge Recovery Among Older Adults Hospitalized for Heart Failure in the United States [0.03%]
美国老年人因心力衰竭住院后的出院恢复与颗粒物空气污染的关系
Tong Wen,Jingwen Hu,Michelle Shardell et al.
Tong Wen et al.
Background: The impact of exposure to fine particulate matter (PM2.5) on post-discharge recovery in older adults already hospitalized for heart failure remains unclear. We evaluated associations between exposure to PM2.5 ...
Atlas of Human Cerebellar Aging: Nonlinear Molecular Trajectories Reveal Multidimensional Mechanisms Underlying Cognitive and Motor Function Regulation [0.03%]
人类小脑衰老图谱：非线性分子轨迹揭示了调节认知和运动功能的多维机制
Xiuling Ma,Likun Zhao,Hongxin Pan et al.
Xiuling Ma et al.
The cerebellum, traditionally recognized for motor coordination, may also contribute to cognitive and emotional regulation, as recent evidence indicates. However, the molecular and structural changes in the human cerebellum during healthy a...
Differences in blood levels of neuroligin-derived peptides in a cohort for early detection of Alzheimer's disease [0.03%]
用于阿尔茨海默病早期诊断队列中神经突粘蛋白衍生肽的血液水平差异
Milton Guilherme Forestieri Fernandes,Maxime Pinard,Esen Sokullu et al.
Milton Guilherme Forestieri Fernandes et al.
Alzheimer's disease (AD) develops gradually, with significant neurodegeneration already present by the time clinical symptoms emerge. Since synapses are affected early in the disease, synaptic proteins are being investigated as potential ma...
The Impact of Hearing Loss on Annual Incident Age-Associated Dementia Cases and Quality of Life in the US [0.03%]
美国听力损失对年度新发年龄相关痴呆病例及生活质量的影响
Ethan D Borre,Julie N Deleger,Lauren K Dillard et al.
Ethan D Borre et al.
Background: One-third of persons age 60 y+ have hearing loss, and hearing loss is a leading preventable risk factor for dementia. We estimated the number of age-associated dementia cases attributable to hearing loss in 20...
Determinants of Oral Functions and Oral Frailty in Older Community-dwelling Individuals: A Comprehensive Analysis [0.03%]
社区老年人口腔功能及口腔脆弱性的决定因素：全面分析
Leming Jia,Anastasios Grigoriadis,Ayumi Suzuki et al.
Leming Jia et al.
Background: Aging alters oral structures, affecting chewing and swallowing function. Oral function is increasingly recognized as an important component of systemic health outcomes in older individuals. Understanding age-r...