Physical Frailty, Self-Rated Health, and All-Cause Mortality: Implications for Understanding Resilience in Aging [0.03%]
衰弱、自我报告的健康状况与全因死亡率之间的关系：理解衰老过程中抗逆力的影响
Vishaldeep Kaur Sekhon,Roshni Wani,Chenkai Wu et al.
Vishaldeep Kaur Sekhon et al.
Frailty and poor self-rated health (SRH) as potential indicators of reduced resilience are associated with all-cause mortality. However, it is lesser known whether these associations are independent of each other, physical disability or dis...
Yannick Stephan,Angelina R Sutin,Martina Luchetti et al.
Yannick Stephan et al.
Background: Early-life IQ is a consistent predictor of overall late life health, but its association with the risk of dementia is inconclusive. The present study examined the association between IQ in adolescence and the ...
Hand grip strength and loss of independence in indigenous and non-Indigenous New Zealand octogenarians-the LiLACS NZ cohort study [0.03%]
新西兰LiLACS NZ队列研究中的手握力与第八十岁左右的土著和非土著人的独立性丧失
Simon A Moyes,Vanessa Selak,Lindsay D Plank et al.
Simon A Moyes et al.
Background: The number of people losing their independence is increasing as the population ages. Sarcopenia, low muscle strength and mass, and hand grip strength (HGS) are known to predict reduced independence in people i...
Analysis of blood-based DNA methylation scores reveals associations with shared cohabitation duration in cohabiting pairs [0.03%]
基于血液的DNA甲基化评分分析揭示了同居夫妇共同居住时间共享与表观遗传年龄加速之间的关联
Joshua Stevenson-Hoare,Martin Stoffel,Ben Schöttker et al.
Joshua Stevenson-Hoare et al.
Individuals who share their environment for long periods of time, i.e., spouses, are likely to share behaviours and exposures, and longer spouse-pair cohabitation durations have been suggested to increase methylation pattern similarity on a...
Caloric Restriction and Time-Restricted Eating in Older Adults with Overweight or Obesity: The Health, Aging, and Later-Life Outcomes Pilot Study [0.03%]
有关老年人群的热量限制和限时进食试点研究：健康、老龄化及远期结局研究
Denise K Houston,Jason Fanning,Barbara J Nicklas et al.
Denise K Houston et al.
Background: In animal models, caloric restriction (CR) and time-restricted eating (TRE) extend lifespan and healthspan; however, the long-term benefits in humans are unknown. The goal of the Health, Aging and Later-Life O...
Weighted Vest Use or Resistance Exercise to Offset Muscle Loss in Older Adults: Secondary Findings from the INVEST in Bone Health RCT [0.03%]
穿戴负重背心或进行抵抗式锻炼以抵消老年人肌肉损失：INVEST促进骨健康随机临床试验的次要发现
S Delanie Lynch,Marjorie Howard,Daniel P Beavers et al.
S Delanie Lynch et al.
Background: The INVEST in Bone Health Trial examined the effects of weight loss (WL), WL plus resistance training (WL+RT), or WL plus weighted vest use (WL+VEST) on musculoskeletal health. This secondary analysis evaluate...
Impact of National Partnership to Improve Dementia Care on Antipsychotic Use Duration for Dementia Residents in Nursing Homes [0.03%]
改善痴呆症护理国家合作项目对疗养院痴呆症居民抗精神病药物使用时长的影响
Theresa I Shireman,Corinne Roma,Andrew R Zullo et al.
Theresa I Shireman et al.
Background: Federal policies have successfully targeted the prevalence of antipsychotic (AP) exposure in NHs, but the duration of treatment among nursing home (NH) residents has not been reported. We evaluated AP duration...
Impact of sleep habits on life expectancy free of cardiovascular disease in the Chinese population: a prospective cohort study [0.03%]
中国人群睡眠习惯对无心血管疾病预期寿命的影响：前瞻性队列研究
Qiufen Sun,Jingcen Hu,Canqing Yu et al.
Qiufen Sun et al.
Background: Abnormal sleep duration and poor sleep quality have been associated with increased risks of cardiovascular disease (CVD) incidence and mortality. However, little is known about how these sleep problems affect ...
From rash to resilience: how herpes zoster vaccination may influence inflammation, aging biology, and dementia risk [0.03%]
从鲁莽到韧性：带状疱疹疫苗接种如何影响炎症、衰老生物学和痴呆症风险
Nicola Veronese
Nicola Veronese
Sex-specific proteostasis and urothelial responses to senolytic therapy in the aged mouse bladder [0.03%]
老龄小鼠膀胱中性别特异性蛋白稳态及尿路上皮对senolytic疗法的反应
Sumiran Kasturi,Arnold M Salazar,Cara Hardy et al.
Sumiran Kasturi et al.
Lower urinary tract dysfunction (LUTD) increases with age and disproportionately affects women, yet the molecular mechanisms underlying this sex bias remain poorly defined. The aging bladder plays a central role in this decline, and our pre...