Developing the Right for You? intervention to improve engagement in community-based palliative care: A feasibility study and pilot test [0.03%]
一项改善社区姑息性护理参与度的“Right for You?”干预措施的研发：可行性研究和试点试验
Elizabeth Luth,Denalee O&#x;Malley,Carlin Brickner et al.
Elizabeth Luth et al.
Background: Community-based palliative care (CBPC) can improve symptom management and quality of life at reduced costs (through hospitalization prevention) for seriously ill older adults. However, CBPC services are underu...
External Validation of an AI-based Preoperative Frailty Index using Real-World Data [0.03%]
基于人工智能的术前脆弱性指数的外部验证研究
Chen Bai,Feifei Xiao,Mohammad Al-Ani et al.
Chen Bai et al.
Background: Preoperative frailty assessment is crucial for surgical risk stratification in older adults. Traditional frailty measurements are often too time-consuming and resource-intensive in preoperative settings. This ...
The associations of joint exposure to various living environmental factors with the risk of frailty and all-cause mortality: a nationally representative cohort study [0.03%]
多种生活环境因素联合作用与衰弱和全因死亡率关联的队列研究
Jinqi Wang,Xiaoyu Zhao,Yanchen Zhao et al.
Jinqi Wang et al.
Background: The relationships of joint exposure to various outdoor and indoor environmental factors with the risk of frailty and mortality remain unclear. ...
Acute NAD+ Supplementation via NMN Does Not Rescue Functional Impairment in a LPS-Induced Delirium Mouse Model [0.03%]
急性补充NMN以增加烟酰胺腺嘌呤二核苷酸(NAD+)的含量无法改善内毒素诱导的小鼠谵妄模型的学习与记忆功能损伤
M K Kirsten Chui,Prasanna Vadhana Ashok Kumaar,Birgit Schilling et al.
M K Kirsten Chui et al.
Delirium is a serious neuropsychiatric condition that lacks an effective treatment intervention. A confusional state often brought on by acute illness, delirium is associated with acute inflammation and metabolic dysfunction. NAD+ is a meta...
Baseline Plasma GDF15 and Recovery of Physical Function Following Total Knee Replacement in The Study of Physical Resilience and Aging [0.03%]
基线血浆GDF15与全身膝关节置换术后身体功能恢复的关系——来自老年生理应对能力研究的证据
William A Fountain,Nicholas Milcik,Nicholas Schmedding et al.
William A Fountain et al.
Growth-differentiation factor 15 (GDF15), a cytokine with the ability to regulate metabolic and inflammatory activity, is negatively associated with physical and cognitive function, and increases in circulation with age. Mechanistically, th...
The triglyceride-glucose index as a measure of insulin resistance, mediated the relationship between air pollution and hypertension in middle-aged and older adults [0.03%]
三酰甘油-葡萄糖指数介导了空气污染与中老年人高血压的关系
Jinglong Zhang,Jia Chen,Jing Nie et al.
Jinglong Zhang et al.
Background: Previous studies have identified links between air pollution, insulin resistance (IR), and hypertension risk, but the mediating role of IR in the relationships between air pollution exposure and hypertension r...
Mitochondrial bioenergetic profiling in T cell subsets associates with functional health in older adults: A cross-sectional analysis from the INSPIRE-T cohort [0.03%]
INSPIRE-T队列的横断面分析：T细胞亚群中的线粒体生物能量特征与老年人的功能健康相关性研究
Nabila Jabrane-Ferrat,Jérémy Raffin,Jordi Gouilly et al.
Nabila Jabrane-Ferrat et al.
Aging varies across individuals, highlighting the need for better markers of functional decline. This study investigates the hypothesis that T cell energy metabolism is correlated with functional health in older adults. We used flow cytomet...
Higher Circulating Alpha-Klotho Levels Increase All-Cause Mortality Through Mediation Effects of Liver Fibrosis: A Second Analysis of NHANES [0.03%]
循环中较高α-洛斯霍托蛋白水平通过介导肝纤维化增加全因死亡率：NHANES的二次分析结果
Kai Wei,Qing Zhang,Chun Chen et al.
Kai Wei et al.
Background: Laboratory studies have demonstrated that mice with α-klotho gene deficiency experience a shortened lifespan, but epidemiological evidence linking circulating α-klotho levels and mortality remain inconclusiv...
Comparative Effectiveness of Metformin vs Sulfonylureas on Exceptional Longevity in Women with Type 2 Diabetes: Target Trial Emulation [0.03%]
与磺脲类药物相比，二甲双胍对2型糖尿病女性患者特异长寿的影响：靶试验模拟研究
Aladdin H Shadyab,Mark A Espeland,Andrew O Odegaard et al.
Aladdin H Shadyab et al.
Background: The association of metformin with mortality has been mixed, and no prior study has determined whether metformin initiation is associated with exceptional longevity, defined as survival to ages 90 and older. ...
Cognitive stability among plasma p-tau 181 negative individuals: a 5-year analysis of the MAPT study [0.03%]
MAPT研究中血浆p-tau 181阴性个体的认知稳定性：一项为期五年的分析
Federico Bellelli,Philipe De Souto Barreto,Christelle Cantet et al.
Federico Bellelli et al.
Background: This study aims to assess the evolution of cognitive performances over a five-year follow-up period in community-dwelling older people with negative plasma p-tau181 levels and to determine whether frailty coul...