Large extension of C. elegans lifespan in diluted axenic medium: a balancing act between different survival responses [0.03%]
线虫稀释无菌培养基中的寿命延长：不同生存反应的平衡作用
Ping Wu,Lieselot Vandemeulebroucke,Kevin Rey A Guiritan et al.
Ping Wu et al.
Axenic dietary restriction (ADR) represents a powerful and unique DR regimen for C. elegans as it robustly extends lifespan independently of well-known key genes associated with DR, such as those of insulin/IGF-1 signaling, skn-1, and pha-4...
Frailty and Physical Activity: Are all Physical Activity Variables Equal? [0.03%]
虚弱与身体活动：所有身体活动变量都同等重要吗？
Mariana Wingood,Byron C Jaeger,Jason Fanning et al.
Mariana Wingood et al.
Background: Frailty, defined as diminished physiological and functional reserve, is linked to negative health outcomes such as falls, fractures, and disability. Physical activity dose plays a significant role in preventin...
Longitudinal Associations of Depression and Diabetes with Alzheimer's Disease and Related Dementias Risk among American Indian and Alaska Native Peoples [0.03%]
美国原住民和阿拉斯加本地人抑郁症和糖尿病与阿尔茨海默病和其他痴呆症风险的纵向关联
R Turner Goins,Yuxi Shi,Maria M Corrada et al.
R Turner Goins et al.
Background: Alzheimer's disease and related dementias (ADRD) research worldwide indicate that it is more common in Indigenous than in non-Indigenous populations. We examined the relationship of depression and diabetes, al...
Longitudinal Associations Between Medication Use and Phenotypic Aging: Insights from the Baltimore Longitudinal Study of Aging [0.03%]
基于巴尔的摩纵向衰老研究的用药与表型衰老之间的纵向关系分析
Bowen Tang,Perry Kuo,Ann Zenobia Moore et al.
Bowen Tang et al.
Background: Limited population-based data exist on the association between medication use and changes in phenotypic aging. This study investigated these associations using data from the Baltimore Longitudinal Study of Agi...
Sleep, Carotid Intima-Media Thickness and Arterial Stiffness: Results from a Large Longitudinal Cohort Study [0.03%]
睡眠、颈动脉中膜厚度和血管僵硬度：一项大型纵向队列研究的结果
Ruirui Wang,Mengyao Shi,Xiangyan Yin et al.
Ruirui Wang et al.
Background: To evaluate the associations of sleep health with carotid intima-media thickness (CIMT) and arterial stiffness. Methods: A ...
Metabolomics-Based Identification and Validation of the Creatine Precursor Guanidinoacetic Acid for Frailty in Older Adults [0.03%]
基于代谢组学的胍基乙酸作为老年人脆弱性的肌苷前体的识别和验证
Yin Yuan,Xiaoming Huang,Siyang Lin et al.
Yin Yuan et al.
Backgound: Subtle biological changes related to frailty may be undetected by standard clinical methods, and reliable biomarkers for frailty are still under investigation. This study was conducted to profile plasma metabol...
Advanced brain aging, selective vulnerability in gray matter, and cognition in Parkinson's disease [0.03%]
帕金森病的高级脑老化、灰质的选择性易损性和认知功能
Mengfei Cai,Chentao He,Hao Li et al.
Mengfei Cai et al.
Background: To identify the most vulnerable brain regions in gray matter attributable to advanced brain aging and examine the cognitive correlates of advanced brain aging in Parkinson's disease (PD). ...
Long-term air pollutants exposure on risk of psoriasis: the mediating role of accelerated biological aging among 284,544 participants [0.03%]
长期空气污染暴露与银屑病发病风险的关系：基于284544名参与者的加速生物学衰老的中介作用研究
Jie Gao,Jiarong He,Wenbo Zhao et al.
Jie Gao et al.
Psoriasis burdens children and adults, but the impact of air pollution and aging is unclear. This study examines the association between air pollution exposure and psoriasis risk, considering the mediating role of biological aging. A prospe...
Systemic Inflammation as a Moderator of Air Pollution-Associated Self-Reported Health in Middle-aged and Older Chinese Adults: Evidence from a Nationwide Study [0.03%]
系统性炎症对中国中老年人群空气污染自报健康效应的调节作用—基于全国多城市研究的证据
Boye Fang,Danyu Li,Zhongwang Wei
Boye Fang
Prolonged exposure to air pollution and systemic inflammation has both been associated with deteriorating self-reported health (SRH), however, the underlying mechanisms remained poorly understood. This study included 8,292 middle-aged and o...
Racial Disparities in Palliative Care Among Hospitalized Older Adults with Traumatic Brain Injury [0.03%]
住院老年创伤性脑损伤患者姑息治疗中的种族差异
Jennifer S Albrecht,Justin Price,Chih Chun Tung et al.
Jennifer S Albrecht et al.
Background: Enhanced understanding of the use of palliative care among older adults with traumatic brain injury (TBI) could help guide development of policy and educational interventions. Our objective was to assess racia...