DunedinPACE Predicts Incident Metabolic Syndrome: Cross-sectional and Longitudinal Data from the Berlin Aging Study II (BASE-II) [0.03%]
纵向和横断面的柏林老龄化研究二期（BASE-II）数据预测肌无力症代谢征候群的发生： Dunedin 多元老化影响评估的影响
Ilja Demuth,Valentin Max Vetter,Jan Homann et al.
Ilja Demuth et al.
Background: Aim of the study was a comparative analysis of different epigenetic clocks with regard to their ability to predict a future onset of the Metabolic Syndrome (MetS). In addition, cross-sectional relationships be...
Using Machine-Learning to Identify Differences in the Association between Blood-Based Biomarkers and Later Life Health Across Race and Ethnicity [0.03%]
利用机器学习识别血液生物标志物与后期生命健康在不同种族和族裔群体中的关联差异
Mateo P Farina,Eric T Klopack,Eileen M Crimmins
Mateo P Farina
Increasingly, biomarkers are used to understand health and health inequalities among older adults. Combined with advancements in machine-learning approaches, researchers are using predictive algorithms of later life health to identify bioma...
MicroRNA signatures of VO2peak in older adult participants of the Study of Muscle, Mobility and Aging [0.03%]
肌肉、 mobility和衰老研究中老年人VO2peak的microRNA标志物
Genesio M Karere,Fang-Chi Hsu,Russell T Hepple et al.
Genesio M Karere et al.
Background: Peak oxygen consumption during exercise (VO2peak), is a direct measure of cardiorespiratory fitness (CF), a key indicator of physical function and overall health. However, the molecular changes that underpin V...
Accelerometer-Measured Multi-dimensional Physical Activity Patterns and Physical Functional Decline: A Prospective National Cohort Study of Aging [0.03%]
基于加速度计的多维体力活动模式与物理功能衰退的关系：一项关于老龄化的前瞻性全国队列研究
Lingjie Fan,Junhan Zhao,Jian Wang et al.
Lingjie Fan et al.
Background: : Physical activity (PA) is crucial for maintaining physical function in older adults, but relationships between multidimensional PA patterns and functional decline remain unclear. This study examined associat...
The Association of a Polygenic Lifespan Score With the Risk of Common Age-Related Diseases and Mortality [0.03%]
多基因寿命评分与常见年龄相关疾病和死亡率的风险之间的关联性研究
Niko Paavo Tynkkynen,Kaisa Koivunen,Päivi Herranen et al.
Niko Paavo Tynkkynen et al.
Background: Aging increases the risk of major noncommunicable diseases. Research into the genetics of health-related traits could reveal genetic pathways for robustness against these diseases. We studied how a genetic pre...
Brittany Intzandt,Safa Sanami,Julia Huck et al.
Brittany Intzandt et al.
Cerebral blood flow (CBF) declines consistently in aging and this decline is a critical component of several late life diseases. Understanding why this occurs in normal aging, prior to pathological changes, is crucial. Physical activity (PA...
A Taxonomy to Characterize Stressor Variation in Studies of Physical Resilience and its Illustration in Total Knee Replacement [0.03%]
一项关于身体韧性研究的压力因素变化分类法及其在全膝关节置换术中的应用示例
Frederick Sieber,Mallak K Alzahrani,Qian-Li Xue et al.
Frederick Sieber et al.
Background: This study aimed to develop a conceptual framework and empirical measures to characterize stressor magnitude and type in the context of total knee replacement (TKR) and to investigate their relationship with r...
Loop diuretics and subsequent use of urinary symptom medications in older adults: evaluation of a possible prescribing cascade [0.03%]
利尿剂与老年人随后使用治疗排尿症状药物的关系：可能的开药级联效应的评估
Matthew E Growdon,Bocheng Jing,W James Deardorff et al.
Matthew E Growdon et al.
Background: Loop diuretic (LD) use may lead to a prescribing cascade whereby urinary symptoms are ascribed to genitourinary syndromes and treated with urinary symptom medications (USMs). We investigated if LDs lead to inc...
Nigrostriatal dopaminergic integrity in relation to prefrontal cortex activity and gait performance during dual-task walking in older adults [0.03%]
黑质纹状体多巴胺完整性与老年人双任务行走中前额叶活动和步态表现的关系
Andrea L Rosso,Emma M Baillargeon,Nico I Bohnen et al.
Andrea L Rosso et al.
Background: Walking automaticity facilitates maintenance of gait speed without prefrontal cortex (PFC) resources. Brain aging may cause shifts to attentional gait with greater engagement of the PFC. Nigrostriatal dopamine...
Time to mobilization in hours after surgery for hip fracture and 30-day mortality-A study on 36,229 patients from the Danish Hip Fracture Registry [0.03%]
术后小数日内的髋部骨折动员时间和30天死亡率-来自丹麦髋关节骨折登记中心的36,229名患者的回顾性研究
Morten Tange Kristensen,Ina Trolle Andersen,Bjarke Viberg et al.
Morten Tange Kristensen et al.
Background: Early mobilization after hip fracture (HF) is a key indicator in national registries and associated with reduced mortality, but in-depth analysis of time in hours for mobilization is lacking. We described the ...