Associations of physical frailty with risk of incident cardiovascular disease by mediation of plasma metabolome changes [0.03%]
基于血浆代谢组改变的心肺疾病与机体虚弱的关联性研究
Guangbin Sun,Lan Yu,Nayili Mahemuti et al.
Guangbin Sun et al.
Background: Frailty has been increasingly recognized as a significant contributor to adverse cardiovascular outcomes. However, the metabolic mechanisms underlying this relationship remain unclear. This study aimed to iden...
Social and clinical frailty indices in aging mice: A comparative analysis of longitudinal and cross-sectional designs [0.03%]
纵向和横断设计的小鼠社交和临床脆弱性指数的比较分析
Maria Razzoli,Charles W Collinge,Monica Luciana et al.
Maria Razzoli et al.
Aging is a heterogeneous phenomenon provoked by biological processes that still need to be fully understood. Frailty is a relevant outcome of aging reflecting biological decline that can be quantified through indices measuring the accumulat...
Moving Geroscience Forward in China: Proceedings of the First International Exchange Forum of the Chinese Geriatrics Society [0.03%]
中国健康老龄化之路——中华医学会老年医学分会国际学术论坛论文集
Le Zhang,Tianyi Ji,Jianghan Bi et al.
Le Zhang et al.
Held on 17 August 2025 in Guangzhou, the inaugural International Exchange Forum of the Chinese Geriatrics Society marked a significant milestone in advancing geroscience and fostering global collaboration in China. The forum brought togethe...
Associations of common infections with frailty and mortality in two UK cohort studies [0.03%]
英国两项前瞻性队列研究中普通感染与衰弱和死亡率的关联性研究
Demelza Smeeth,Charlotte Warren-Gash,Rebecca E Green et al.
Demelza Smeeth et al.
Background: Some common infections are associated with poorer age-related health outcomes; however, findings are limited to a small number of pathogens and frequently inconclusive. This study aimed to expand the range of ...
Revisiting socioeconomic disadvantage estimates in the National Health and Aging Trends Study [0.03%]
重新审视国家健康和老龄化趋势研究中的经济社会劣势估计值
Vicki A Freedman,Jennifer A Schrack
Vicki A Freedman
Benchmarking Weighted Estimates of Social Determinants of Health in the National Health and Aging Trends Study (NHATS) [0.03%]
国家健康和老龄化趋势研究(NHATS)中加权估计的社会健康决定因素的基准测试
Thomas M Gill,Linda Leo-Summers,Jingchen Liang et al.
Thomas M Gill et al.
Bidirectional Associations Between Physical Function and Physical Activity Among Older Adults Living with Dementia [0.03%]
痴呆老人身体功能与身体活动的双向关联
Shijun Zhu,Barbara Resnick,Marie Boltz et al.
Shijun Zhu et al.
Background: Previous research has suggested a likely reciprocal relationship between physical function and physical activity among older adults, but few assessed those living with dementia. This study examined the bidirec...
Striatal Dopamine and Skeletal Muscle Energy Metabolism in Older Adults [0.03%]
老年人纹状体多巴胺与骨骼肌能量代谢的关系
Caterina Rosano,Nico I Bohnen,Brian Lopresti et al.
Caterina Rosano et al.
Background: Dopamine (DA) in the central nervous system is considered a master regulator of mobility performance and vigor, but its mechanistic relationship with skeletal muscle energetics is unclear. ...
Development and Validation of Cardiorespiratory Fitness Prediction Equations from 6-Minute Walk Test in the CARDIA Study [0.03%]
基于CARDIA研究的六分钟步行试验心肺适能预测方程的建立和验证
Bjoern Hornikel,Erin E Dooley,C Barrett Bowling et al.
Bjoern Hornikel et al.
Background: Assessing maximal oxygen consumption (VO2max), the gold standard for assessing cardiorespiratory fitness (CRF), is often impractical in large-scale studies. We derived sex-specific VO2max and graded exercise t...
Biomarkers help us understand how cellular and systemic aging contribute to mortality: A study utilizing a machine learning approach in the Health and Retirement Study [0.03%]
生物标志物有助于我们了解细胞和系统衰老如何影响死亡率：利用机器学习方法在健康与退休研究中的应用研究报告
Eric T Klopack,Eileen M Crimmins
Eric T Klopack
Background: Research suggests aging is a coordinated physiological decline occurring in multiple systems and at multiple biological levels. However, it is largely unknown how general biological aging and specific systemic...