Substituting Blood-Based Biomarkers for Imaging Measures in Alzheimer's Disease Studies: Implications for Sample Size and Bias [0.03%]
阿尔茨海默病研究中用血液生物标志物替代影像学测量的样本量和偏差的含义
Sarah F Ackley,Renaud La Joie,Michelle Caunca et al.
Sarah F Ackley et al.
Background: Blood-based biomarkers for Alzheimer's disease (AD) pathology are appealing options in large population-based studies due to their low cost, minimal invasiveness, and feasibility of collection in non-clinical ...
Metabolic Syndrome Duration and Risk of Frailty among Midlife Women: The Study of Women's Health Across the Nation (SWAN) [0.03%]
更年期综合征持续时间和中年妇女脆弱风险的关系：来自女性一生健康研究（SWAN）的证据
Elizabeth A Jackson,Carrie A Karvonen-Gutierrez,Maria M Brooks et al.
Elizabeth A Jackson et al.
Background: Metabolic syndrome is associated with frailty in older adults, with few data among midlife women. We examined metabolic syndrome (MetSyn), including duration, for associations with the development of prefrailt...
ECSIT facilitates exercise-induced amelioration of skeletal muscle atrophy by maintaining mitochondrial quality control in Middle-aged mice [0.03%]
ECSIT促进中年小鼠运动改善肌肉萎缩通过维持线粒体质量控制
Jingcheng Fan,Xin Wen,Xuemei Duan et al.
Jingcheng Fan et al.
Although exercise is well-established in alleviating aging-associated skeletal muscle atrophy, the underlying mechanism is not fully understood. Evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) has been shown to be a...
Dietary One‑Carbon Nutrients and Genetic Risk in Parkinson's Disease: A Prospective Cohort Study [0.03%]
饮食一碳营养素和帕金森病的遗传风险：一项前瞻性队列研究
Junliang Tao,Yongsheng Wang,Xuedan Xia et al.
Junliang Tao et al.
Background: Several studies have investigated the effects of dietary one-carbon metabolism (OCM) nutrients, such as methionine, folate, vitamin B6, and vitamin B12, on Parkinson's disease (PD). However, current evidence r...
Response to: time to mobilization in hours after surgery for hip fracture and 30-day mortality-a study on 36 229 patients from the Danish hip fracture registry [0.03%]
术后多长时间让髋部骨折患者下床活动才好？——基于丹麦髋部骨折登记数据库中３万６千余例患者的队列研究报告
Petrina Lander,Michael B Fertleman,Benjamin H L Harris et al.
Petrina Lander et al.
Morten Tange Kristensen,Ina Trolle Andersen,Bjarke Viberg et al.
Morten Tange Kristensen et al.
Comment on "exploring the relationship between pain, cognition, and chronic conditions: insights from the HAALSI study in rural South Africa" [0.03%]
关于“HAALSI研究：探索疼痛、认知与慢性疾病之间的关系”的评论
Cansu Atbas,Mehmet Ilkin Naharci
Cansu Atbas
Development and validation of a two-step shared parameter model for dementia imputation in the Cardiovascular Health Study Cohort [0.03%]
心血管健康研究队列中痴呆填补的两步共享参数模型的开发与验证
Katie M Lynch,Erin E Bennett,Chelsea Liu et al.
Katie M Lynch et al.
Background: Large-scale dementia ascertainment for research remains challenging. We demonstrate a method to impute dementia status and onset time using data from the Cardiovascular Health Study (CHS). ...
Utility of biological aging markers for mortality risk stratification in community-dwelling older adults: Insights from the Mr. OS & Ms. OS (Hong Kong) cohort [0.03%]
基于社区的老年人死亡风险分层中生物衰老标志物的效用：来自香港男性记忆和老化纵向研究队列的见解
Yafei Wu,Ting Zhang,Shuyi Li et al.
Yafei Wu et al.
Background: Studies regarding the integration of various biological aging (BA) markers and their predictive values for long-term mortality risk remain limited, particularly in Asian older adults. We evaluated the associat...
Epigenetic Age Acceleration and Mortality Among Persons with Poorly Controlled HIV [0.03%]
表观遗传时钟老化与持续病毒学失败的HIV感染患者全因死亡率之间的关系
David W Sosnowski,Chang Shu,Hsing-Yu Hsu et al.
David W Sosnowski et al.
We sought to assess the relationship between HIV infection and disease severity with epigenetic age and to examine the combined association of epigenetic age acceleration and HIV infection with mortality. Participants were drawn from the AL...