Yaru Chen,Xin Liu,Yuyang Song et al.
Yaru Chen et al.
Inflammation is a hallmark of aging and negatively affects ovarian function and female fertility. ISGylation is a post-translational modification regulating many life activities, including inflammation, immunomodulation and embryo implantat...
A simulation study comparing anticholinergic drug use with polypharmacy for risk of death, dementia, and delirium in UK Biobank [0.03%]
英国生物银行中抗胆碱药使用与多种药物联合使用的死亡、痴呆和谵妄风险的比较仿真研究
Jure Mur,Lucy E Stirland,Graciela Muniz-Terrera et al.
Jure Mur et al.
Background: polypharmacy and use of anticholinergics are associated with adverse health outcomes. Because these two exposures covary, it is not known to what extent the detrimental health effects attributed to anticholine...
Associations of intrinsic capacity deficit proxy score and genetic susceptibility with incident CKD and life expectancy [0.03%]
内在能力不足代理评分和遗传易感性与CKD发病率和预期寿命的关系
Gang Zheng,Fengrong Ou,Shuxian Chen et al.
Gang Zheng et al.
Background: Intrinsic capacity (IC), reflecting an individual's physical and mental capacities, is a core concept proposed by WHO to promote healthy aging. This study aimed to examine the association between IC and chroni...
Sex-specific Phosphoproteome Responses to Calorie Restriction and Insulin in Skeletal Muscle from Older Rats [0.03%]
老年大鼠骨骼肌限制摄食和注射胰岛素的性别特异性磷酸蛋白质组学反应
Haiyan Wang,Søren Madsen,Elise J Needham et al.
Haiyan Wang et al.
Calorie restriction (CR; calorie intake reduced by ∼20-40% below ad libitum, AL, intake) potentiates skeletal muscle insulin sensitivity during old age by incompletely understood mechanisms. We aimed to identify CR-induced changes in muscl...
Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging [0.03%]
血清25-羟基维生素D浓度与身体质量指数联合促进基于临床生物标志物的生物学老化加速的作用关系研究
Zimo Pan,Jing Zeng,Zeyu Chen et al.
Zimo Pan et al.
Background: The possible joint association of vitamin D and obesity in regard to the clinical biomarker-based biological aging process has not been well studied. We aimed to investigate the independent and combined associ...
Multi-omics Mendelian Randomization and Single-Cell Analysis Identify Novel Therapeutic Targets for Osteosarcopenia [0.03%]
多组学孟德尔随机化和单细胞分析识别出治疗骨肌减少症的新型治疗靶点
Jiyong Yang,Miaoling Gong,Yi Zhou et al.
Jiyong Yang et al.
Background: Osteosarcopenia, defined by the coexistence of osteoporosis and sarcopenia, presents a significant health challenge for aging populations. The purpose of current study was to identify potential therapeutic tar...
Jianhong Xu,Yanxin Wang,Jonathan Ka-Long Mak et al.
Jianhong Xu et al.
Background: Hip fractures significantly increase health risks in older adults, yet the evolution of frailty before and after fracture and its impact on mortality remain unclear. This study investigated the relationship be...
Benjamin Seligman,Mark Ward,Maddalena Ferranna et al.
Benjamin Seligman et al.
Background: Frailty is a common syndrome among older adults, associated with multiple adverse health outcomes. Work harmonizing frailty measurement across 25 countries and regions and different socioeconomic environments ...
Large-Vessel Hemodynamics Are Associated with Glymphatic Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease [0.03%]
大血管血流动力学与脑小血管病中甘淋巴系统功能障碍及认知损害相关性研究
Dan Luo,Peng Zeng,Bang Zeng et al.
Dan Luo et al.
Background: Disruption of cerebral hemodynamics may impair perivascular and glymphatic clearance, contributing to aging-related brain pathology. This study aimed to explore the interaction between large-vessel hemodynamic...
A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity [0.03%]
全基因组关联研究确定了与内在能力相关的10个新型基因组位点
Melkamu B Beyene,Renuka Visvanathan,Robel Alemu et al.
Melkamu B Beyene et al.
Background: Intrinsic capacity (IC) is a multidimensional concept within the World Health Organization framework for healthy aging. It refers to the composite of an individual's physical and mental capacities that enable ...