Associations of Serum Magnesium and Magnesium Intake with Brain Morphology and Cognitive Function in Puerto Rican Adults [0.03%]
血清镁和镁摄入量与波多黎各成年人脑形态和认知功能的关系
Fan Chen,Yi Guan,Bang-Bon Koo et al.
Fan Chen et al.
Background: Magnesium's (Mg) role in brain aging is under-studied. We examined associations of dietary and serum Mg with MRI and cognitive measures in a cohort with >10 y follow-up. ...
Estimated glucose disposal rate is associated with brain aging and dementia among diabetes-free older adults [0.03%]
估算的葡萄糖清除率与无糖尿病老年人的大脑衰老和痴呆有关
Jiao Wang,Shuqi Wang,Abigail Dove et al.
Jiao Wang et al.
Background: To investigate the association of estimated glucose disposal rate (eGDR), a validated measure of insulin resistance (IR), with brain aging and dementia among diabetes-free people. ...
Association of Systemic Inflammation with Balance and Falls in Older Adults: NHANES and Mendelian Randomization Study [0.03%]
系统性炎症与老年人平衡和跌倒的关联：NHANES和孟德尔随机化研究
Sodiq Fakorede,Kai Cheng,Olubodun M Lateef et al.
Sodiq Fakorede et al.
Background: Falls are a leading cause of morbidity in older adults, with emerging evidence suggesting that systemic inflammation may contribute to this risk. C-reactive protein (CRP), a biomarker of inflammation, has been...
Parental age selection in C. elegans influences progeny stress resistance capacity [0.03%]
父母年龄选择会影响秀丽隐杆线虫后代的应激抵抗力
Bennett T Van Camp,Sean P Curran
Bennett T Van Camp
With parental age rising around the globe, an increased understanding of the impact on health and longevity is needed. Here, we report how the continuous selection of the last progeny during the Caenorhabditis elegans reproductive span resu...
Global Burden of Falls 1990-2021: Aging Effect, Age-Stratified Risk Factors, and Projection to 2040 in Older Adults [0.03%]
1990年至2021年全球跌倒疾病负担：老龄化影响、分年龄段危险因素以及老年人群至2040年的预测
Huimin Chen,Huijing Liu,Yunfei Long et al.
Huimin Chen et al.
Background: Based on data from the Global Burden of Disease (GBD) 2021, this study assessed the burden of falls from 1990 to 2021, with a focus on older adults (≥60 years), regional disparities, and projections to 2040. ...
Longitudinal changes in triglyceride-glucose index and the risk of incident dementia: a prospective cohort study [0.03%]
横截面和纵向研究：三酰甘油-葡萄糖指数与痴呆风险的关系
Tian Ge,Yihong Ding,Minqing Yan et al.
Tian Ge et al.
Background: The triglyceride-glucose (TyG) index, a practical and reliable indicator for insulin resistance, has been linked to an increased risk of dementia. However, the impact of its longitudinal changes on dementia ri...
High-Sensitivity Cardiac Troponin I and Frailty: Associations with the Frailty Index and Fried Phenotype in Older Women [0.03%]
高敏感性心肌肌钙蛋白I与脆弱的关系：与老年女性的脆弱指数和弗莱德表型的相关性
Jedd Pratt,Abadi Gebre,Carlos J Toro-Huamanchumo et al.
Jedd Pratt et al.
Despite the nexus between cardiovascular health and frailty, the relevance of high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, to frailty is poorly understood. We examined whether hs-cTnI concentrations were ...
Exercise-induced alleviation of memory impairment in aged mice with neuroinflammation is linked with modulation of mitochondrial homeostasis in the hippocampus [0.03%]
运动改善老年炎症状态小鼠海马记忆缺损与线粒体稳态调节有关
Peng-Da Li,Chong Han,Yuan-Yuan Qin et al.
Peng-Da Li et al.
Neuroinflammation is a critical aspect of aging and neurodegenerative disorders, increasingly recognized for its significant role in the progression of cognitive impairments. Mitochondrial homeostasis is closely linked to cognitive function...
The Predictive Power of Brain-Predicted Age and Leg Strength on Mobility Decline in Aging: Findings from the Baltimore Longitudinal Study of Aging [0.03%]
来自巴尔的摩衰老纵向研究的发现：脑部预测年龄和腿部力量对老龄人群体行动能力下降的预测力
Brooke A Vaughan,Graciela Muniz-Terrera,Janet E Simon et al.
Brooke A Vaughan et al.
Muscle weakness and poor brain health both contribute to mobility limitations in older adults, but their respective contributions and interaction are not well-understood. This study examines the relationship between MRI-estimated brain-pred...
From Mitochondrial Dysfunction to Frailty and Sarcopenia: Genetic Evidence from Multi-Omics Data via Mendelian Randomization and Colocalization [0.03%]
从线粒体功能障碍到衰弱和肌少症：通过孟德尔随机化和共定位的多组学数据遗传证据
Abudunaibi Wupuer,Xing Peng,Jie Wang et al.
Abudunaibi Wupuer et al.
Background: Frailty and sarcopenia are age-related conditions linked to mitochondrial dysfunction, but their causal mechanisms remain poorly defined. This study aimed to identify mitochondrial-related genes causally assoc...