Increased Efficiency of Mitochondrial Coupling With a Reduction in Other Mitochondrial Respiratory Parameters in Peripheral Blood Mononuclear Cells Is Observed in Older Adults [0.03%]
老年受试者外周血单个核细胞中线粒体偶联效率升高且呼吸参数降低
Sirawit Sriwichaiin,Nattayaporn Apaijai,Arintaya Phrommintikul et al.
Sirawit Sriwichaiin et al.
Mitochondrial dysfunction is a factor potentially contributing to the Aging process. However, evidence surrounding changes in mitochondrial function and aging is still limited; therefore, this study aimed to investigate further the associat...
Angiotensin (1-7) Delivered Orally via Probiotic in Combination With Exercise: Sex-Dependent Influence on Health Span [0.03%]
口服血管紧张素(1-7)/益生菌结合运动对健康寿命的影响：性别差异效应
Abbi Hernandez,Yi Sun,Anisha Banerjee et al.
Abbi Hernandez et al.
Age-related declines in physical and cognitive function can have tremendous, negative impacts on health span and quality of life. Therefore, we investigated the potential of utilizing a probiotic treatment to target the renin-angiotensin sy...
The Association Between Midlife Leisure-Time Physical Activity and Hearing Loss in Late Life in the Atherosclerosis Risk in Communities Study [0.03%]
社区动脉粥样硬化风险研究中中年时期闲暇运动与晚年听力损失之间的关系
Pablo Martinez-Amezcua,Emmanuel Garcia Morales,Kelley P Gabriel et al.
Pablo Martinez-Amezcua et al.
Background: Hearing loss is highly prevalent in older ages and has several health consequences. Some cardiovascular risk factors are associated with worse hearing at older ages. Still, the role of midlife leisure-time phy...
Blunted Rest-Activity Circadian Rhythm Is Associated With Increased Rate of Biological Aging: An Analysis of NHANES 2011-2014 [0.03%]
昼夜生理节律迟钝与生物衰老加速有关：基于NHANES 2011-2014数据分析
Yanyan Xu,Xiaoling Wang,Daniel W Belsky et al.
Yanyan Xu et al.
Impaired rest-activity circadian rhythm has been associated with increased risk for morbidity and mortality. Animals with mutations in clock genes display accelerated aging and shortened life span. Whether impaired rest-activity circadian r...
Polypharmacy With High Drug Burden Index (DBI) Alters the Gut Microbiome Overriding Aging Effects and Is Reversible With Deprescribing [0.03%]
高药物负担指数（DBI）的多重用药会改变肠道菌群，其影响大于衰老并可在减药后逆转
Gizem Gemikonakli,John Mach,Fan Zhang et al.
Gizem Gemikonakli et al.
Aging, medication use, and global function are associated with changes in the microbiome. However, their interrelationships and changes over time require further characterization. In a longitudinal aging mouse study, we investigated the eff...
Genetic and Environmental Influences on Longitudinal Frailty Trajectories From Adulthood into Old Age [0.03%]
遗传和环境因素对从中年到老年脆弱性纵向轨迹的影响
Jonathan K L Mak,Ralf Kuja-Halkola,Ge Bai et al.
Jonathan K L Mak et al.
Background: Frailty is a complex, dynamic geriatric condition, but limited evidence has shown how genes and environment may contribute to its longitudinal changes. We sought to investigate sources of individual difference...
Sensorimotor and Frontoparietal Network Connectivity Are Associated With Subsequent Maintenance of Gait Speed and Episodic Memory in Older Adults [0.03%]
感觉运动和 frontal-parietal 网络连接性与老年人随后的步速和情景记忆保持有关
Chun Liang Hsu,Brad Manor,Thomas Travison et al.
Chun Liang Hsu et al.
Background: Slow gait is predictive of functional impairments in older adults, while concomitant slow gait and cognitive complaints are associated with a greater risk for cognitive decline and dementia. However, functiona...
Bidirectional Links of Daily Sleep Quality and Duration With Pain and Self-rated Health in Older Adults' Daily Lives [0.03%]
老年人日常生活中的每日睡眠质量与持续时间相互关联以及与疼痛和自评健康的关系
Anna J Lücke,Cornelia Wrzus,Denis Gerstorf et al.
Anna J Lücke et al.
Background: Sleep and health perceptions, such as self-ratings of pain and health are closely linked. However, the temporal ordering of such associations is not well understood, and it remains unclear whether sleep qualit...
The Association of Epigenetic Age Acceleration and Multimorbidity at Age 90 in the Women's Health Initiative [0.03%]
表观遗传年龄加速与女性健康倡议研究中90岁高龄妇女的多发病的关系
Purva Jain,Alexandra Binder,Brian Chen et al.
Purva Jain et al.
Background: Epigenetic age acceleration (EAA), a measure of accelerated biological aging, has been associated with an increased risk of several age-related chronic conditions. This is the first study to prospectively exam...
Leucine Intake and Risk of Impaired Physical Function and Frailty in Older Adults [0.03%]
老年成年人的亮氨酸摄入与身体功能受损和脆弱化的风险关系研究
Veronica Vega-Cabello,Francisco Felix Caballero,Fernando Rodriguez-Artalejo et al.
Veronica Vega-Cabello et al.
Background: Leucine is suggested to play a central role in age-related physical decline, but the effect of dietary leucine intake on physical functioning is uncertain. We examined the prospective association between dieta...