Public Health Need, Molecular Targets, and Opportunities for the Accelerated Development of Function-Promoting Therapies: Proceedings of a National Institute on Aging Workshop [0.03%]
公共卫生需求，分子靶点以及加速发展功能促进疗法的机遇：国家老龄化研究所研讨会会议纪要
Rosaly Correa-de-Araujo,Shalender Bhasin
Rosaly Correa-de-Araujo
Background: People ≥ 65 years are expected to live a substantial portion of their remaining lives with a limiting physical condition and the numbers of affected individuals will increase substantially due to the growth o...
Chronic, Mild Hypothermic Environmental Temperature Does Not Ameliorate Cognitive Deficits in an Alzheimer's Disease Mouse [0.03%]
慢性轻度低体温环境温度不能改善阿尔茨海默病小鼠的认知缺陷
Samuel McFadden,Lindsey N Sime,MaKayla F Cox et al.
Samuel McFadden et al.
Metabolic dysfunction increases with age and is a contributing factor to Alzheimer's disease (AD) development. We have previously observed impaired insulin sensitivity and glucose homeostasis in the APP/PS1 model of AD. To improve these par...
Does High-Velocity Resistance Exercise Elicit Greater Physical Function Benefits Than Traditional Resistance Exercise in Older Adults? A Systematic Review and Network Meta-Analysis of 79 Trials [0.03%]
高冲击抗阻运动是否比传统抗阻运动在老年人中产生更大的身体功能效益？对79项试验的系统评价和网络Meta分析
Pedro Lopez,Anderson Rech,Maria Petropoulou et al.
Pedro Lopez et al.
Background: A systematic review and network meta-analysis was undertaken to examine the effectiveness of different modes of resistance exercise velocity in fast walking speed, timed-up and go, 5-times sit-to-stand, 30-sec...
Fasting and Post-Load Glucose and Non-Esterified Fatty Acids and Risk of Heart Failure and Its Subtypes in Older Adults [0.03%]
空腹和口服葡萄糖负荷后血糖及非酯化脂肪酸与老年人心力衰竭及其类型风险的关系
Adam Oesterle,Petra Buzkova,Cara N Pellegrini et al.
Adam Oesterle et al.
Background: Glucose and non-esterified fatty acids (NEFA) are myocardial fuels whose fasting and post-prandial levels are under different homeostatic regulation. The relationships of fasting and post-load glucose and NEFA...
The Association Between Exposure to Air Pollution and Dementia Incidence: The Modifying Effect of Smoking [0.03%]
空气污染暴露与痴呆症发生之间的关联：吸烟的调节效应
Guo-Chong Chen,Daniel Nyarko Hukportie,Zhongxiao Wan et al.
Guo-Chong Chen et al.
Background: The influence of overall air pollution on dementia risk and the potential effect modification by other risk factors remain to be clarified. Me...
Periostin Plasma Levels and Changes on Physical and Cognitive Capacities in Community-Dwelling Older Adults [0.03%]
periostin血浆水平和社区居住的老年人的体能和认知能力的变化
Juan Luis Sánchez-Sánchez,Isabelle Ader,Yannick Jeanson et al.
Juan Luis Sánchez-Sánchez et al.
Periostin, involved in extracellular matrix development and support, has been shown to be elevated in senescent tissues and fibrotic states, transversal signatures of aging. We aimed to explore associations between plasma periostin and phys...
Mitochondrial Dysfunction and Intrinsic Capacity: Insights From a Narrative Review [0.03%]
线粒体功能障碍与内在能力：一篇叙述性综述的见解
Jaqueline Aragoni da Silva,Yves Rolland,Laurent O Martinez et al.
Jaqueline Aragoni da Silva et al.
Mitochondrial dysfunction occurs during aging and may play a role, by distinct mechanisms, in the loss of intrinsic capacity (IC), operationalized through 5 domains: locomotion, psychological, cognition, vitality/nutrition, and sensory (hea...
What We've Learned From the Women's Health Initiative Participants About Their COVID-19 Experience [0.03%]
从女性健康倡议参与者那里了解的有关她们COVID-19体验的信息
Jennifer W Bea,Andrea LaCroix,Sally A Shumaker
Jennifer W Bea
Muscle Endurance and Self-Perceived Fatigue Predict Decline in Gait Speed and Activities of Daily Living After 1-Year Follow-Up: Results From the BUTTERFLY Study [0.03%]
肌肉耐力和自我感知疲劳可以预测步速及日常生活活动能力的下降：蝴蝶研究一年后随访结果
Veerle Knoop,Axelle Costenoble,Aziz Debain et al.
Veerle Knoop et al.
Background: Fatigue might influence the losses in activities of daily living (ADL). When fatigue parameters are present before the experience of losses in ADL and gait speed, they can be used as early warning signals. Thi...
Relationship of Self-reported and Performance-based Visual Function With Performance-based Measures of Physical Function: The Health ABC Study [0.03%]
自报和基于性能的视觉功能与身体功能基于性能的测量的关系：健康ABC研究
Atalie C Thompson,Michael E Miller,Christopher C Webb et al.
Atalie C Thompson et al.
Background: To assess the relationship between self-reported and performance-based visual impairment (VI) and lower extremity physical function. Methods: ...