Polypharmacy With High Drug Burden Index (DBI) Alters the Gut Microbiome Overriding Aging Effects and Is Reversible With Deprescribing [0.03%]
高药物负担指数（DBI）的多重用药会改变肠道菌群，其影响大于衰老并可在减药后逆转
Gizem Gemikonakli,John Mach,Fan Zhang et al.
Gizem Gemikonakli et al.
Aging, medication use, and global function are associated with changes in the microbiome. However, their interrelationships and changes over time require further characterization. In a longitudinal aging mouse study, we investigated the eff...
Genetic and Environmental Influences on Longitudinal Frailty Trajectories From Adulthood into Old Age [0.03%]
遗传和环境因素对从中年到老年脆弱性纵向轨迹的影响
Jonathan K L Mak,Ralf Kuja-Halkola,Ge Bai et al.
Jonathan K L Mak et al.
Background: Frailty is a complex, dynamic geriatric condition, but limited evidence has shown how genes and environment may contribute to its longitudinal changes. We sought to investigate sources of individual difference...
Sensorimotor and Frontoparietal Network Connectivity Are Associated With Subsequent Maintenance of Gait Speed and Episodic Memory in Older Adults [0.03%]
感觉运动和 frontal-parietal 网络连接性与老年人随后的步速和情景记忆保持有关
Chun Liang Hsu,Brad Manor,Thomas Travison et al.
Chun Liang Hsu et al.
Background: Slow gait is predictive of functional impairments in older adults, while concomitant slow gait and cognitive complaints are associated with a greater risk for cognitive decline and dementia. However, functiona...
Bidirectional Links of Daily Sleep Quality and Duration With Pain and Self-rated Health in Older Adults' Daily Lives [0.03%]
老年人日常生活中的每日睡眠质量与持续时间相互关联以及与疼痛和自评健康的关系
Anna J Lücke,Cornelia Wrzus,Denis Gerstorf et al.
Anna J Lücke et al.
Background: Sleep and health perceptions, such as self-ratings of pain and health are closely linked. However, the temporal ordering of such associations is not well understood, and it remains unclear whether sleep qualit...
The Association of Epigenetic Age Acceleration and Multimorbidity at Age 90 in the Women's Health Initiative [0.03%]
表观遗传年龄加速与女性健康倡议研究中90岁高龄妇女的多发病的关系
Purva Jain,Alexandra Binder,Brian Chen et al.
Purva Jain et al.
Background: Epigenetic age acceleration (EAA), a measure of accelerated biological aging, has been associated with an increased risk of several age-related chronic conditions. This is the first study to prospectively exam...
Leucine Intake and Risk of Impaired Physical Function and Frailty in Older Adults [0.03%]
老年成年人的亮氨酸摄入与身体功能受损和脆弱化的风险关系研究
Veronica Vega-Cabello,Francisco Felix Caballero,Fernando Rodriguez-Artalejo et al.
Veronica Vega-Cabello et al.
Background: Leucine is suggested to play a central role in age-related physical decline, but the effect of dietary leucine intake on physical functioning is uncertain. We examined the prospective association between dieta...
Cognitive Improvement Following Physical Exercise and Cognitive Training Intervention for Older Adults With MCI [0.03%]
针对轻度认知障碍老年人的认知训练和身体锻炼干预后的认知改善效果
Elizabeth B Campbell,Mia Delgadillo,Laura C Lazzeroni et al.
Elizabeth B Campbell et al.
Background: The diagnosis of mild cognitive impairment (MCI) presents a critical period for intervention. Although exercise and cognitive training (CT) interventions have reported independent success in improving cognitio...
Continuity of Care Among Postmenopausal Women With Cardiometabolic Diseases in the United States Early During the COVID-19 Pandemic: Findings From the Women's Health Initiative [0.03%]
美国妇女健康倡议在COVID-19大流行初期患有心血管代糖病的绝经后女性的连续护理情况
Eugenia Wong,Nora Franceschini,Lesley F Tinker et al.
Eugenia Wong et al.
Background: In response to the COVID-19 pandemic, public health measures, including stay-at-home orders, were widely instituted in the United States by March 2020. However, few studies have evaluated the impact of these m...
Pulmonary Function Trajectories Preceding Death Among Older Adults: A Long-Term Community-Based Cohort Study [0.03%]
基于社区的长期队列研究中老年人死亡前肺功能轨迹分析
Jiao Wang,Jie Guo,Abigail Dove et al.
Jiao Wang et al.
Background: Poor pulmonary function (PF) has been linked to mortality, but the timing of PF changes before death remains unclear. We aimed to examine the association between PF and mortality and identify different PF traj...
Associations Between Objectively Measured Sleep and Cognition: Main Effects and Interactions With Race in Adults Aged ≥50 Years [0.03%]
客观测量的睡眠与认知之间的关系：不同种族老年人的主要效应和交互作用
Jocelynn T Owusu,Jill A Rabinowitz,Marian Tzuang et al.
Jocelynn T Owusu et al.
Background: This study examined associations of actigraphy-estimated sleep parameters with concurrent and future cognitive performance in adults aged ≥ 50 years and explored interactions with race. ...