Bioprinting of scaled-up meniscal grafts by spatially patterning phenotypically distinct meniscus progenitor cells within melt electrowritten scaffolds [0.03%]
利用熔融电写入支架在空间上对具有表型差异的半月板祖细胞进行图案化的大规模生物打印半月板移植物
Xavier Barceló,Kian Eichholz,Inês Gonçalves et al.
Xavier Barceló et al.
Meniscus injuries are a common problem in orthopedic medicine and are associated with a significantly increased risk of developing osteoarthritis. While developments have been made in the field of meniscus regeneration, the engineering of c...
Long-term in vitro culture of 3D brain tissue model based on chitosan thermogel [0.03%]
基于壳聚糖热胶的三维脑组织模型的长期体外培养
Donatella Di Lisa,Lorenzo Muzzi,Alberto Lagazzo et al.
Donatella Di Lisa et al.
Methods for studying brain function and disease heavily rely onin vivoanimal models,ex-vivotissue slices, and 2D cell culture platforms. These methods all have limitations that significantly impact the clinical translatability of results. C...
Sibo Jing,Liming Lian,Yingying Hou et al.
Sibo Jing et al.
The three-dimensional (3D) bioprinting technologies are suitable for biomedical applications owing to their ability to manufacture complex and high-precision tissue constructs. However, the slow printing speed of current layer-by-layer (bio...
A novel perfusion bioreactor promotes the expansion of pluripotent stem cells in a 3D-bioprinted tissue chamber [0.03%]
一种新型灌注生物反应器促进三维生物打印组织室中多能干细胞的扩增
Elizabeth R Komosa,Wei-Han Lin,Bhushan Mahadik et al.
Elizabeth R Komosa et al.
While the field of tissue engineering has progressed rapidly with the advent of 3D bioprinting and human induced pluripotent stem cells (hiPSCs), impact is limited by a lack of functional, thick tissues. One way around this limitation is to...
Micropatterning the organization of multicellular structures in 3D biological hydrogels; insights into collective cellular mechanical interactions [0.03%]
三维生物水凝胶中多细胞结构的微图案化；集体细胞机械相互作用的见解
Bar Ergaz,Shahar Goren,Ayelet Lesman
Bar Ergaz
Control over the organization of cells at the microscale level within supporting biomaterials can push forward the construction of complex tissue architectures for tissue engineering applications and enable fundamental studies of how tissue...
Enhancement of properties of a cell-laden GelMA hydrogel-based bioink via calcium phosphate phase transition [0.03%]
通过钙磷酸盐相变增强基于细胞凝胶明胶的生物墨水性能
Jueun Kim,Naren Raja,Yeong-Jin Choi et al.
Jueun Kim et al.
To improve the properties of the hydrogel-based bioinks, a calcium phosphate phase transition was applied, and the products were examined. We successfully enhanced the mechanical properties of the hydrogels by adding small amounts (< 0.5 wt...
Novel 3D-printing bilayer GelMA-based hydrogel containing BP, β-TCP and exosomes for cartilage-bone integrated repair [0.03%]
一种新型的含有BP、β-TCP和外泌体的三维凝胶状明胶包卷基质混杂水凝胶用于软骨-骨一体化修复
Ting Sun,Zhiqiang Feng,Wenpeng He et al.
Ting Sun et al.
The integrated repair of cartilage and bone involves the migration and differentiation of cells, which has always been a difficult problem to be solved. We utilize the natural biomaterial gelatin to construct gelatin methacryloyl (GelMA), a...
An injectable and 3D printable pro-chondrogenic hyaluronic acid and collagen type II composite hydrogel for the repair of articular cartilage defects [0.03%]
一种可注射和具有三维打印能力的促软骨生成透明质酸-Ⅱ型胶原复合水凝胶修复关节软骨缺损
Donagh G O&#x;Shea,Tom Hodgkinson,Caroline M Curtin et al.
Donagh G O&#x;Shea et al.
Current treatments for repairing articular cartilage defects are limited. However, pro-chondrogenic hydrogels formulated using articular cartilage matrix components (such as hyaluronic acid (HA) and collagen type II (Col II)), offer a poten...
Ultrasound standing wave spatial patterning of human umbilical vein endothelial cells for 3D micro-vascular networks formation [0.03%]
超声驻波模式化人类脐静脉内皮细胞形成三维微血管网络
Huong Thi Le,Huu Lam Phan,Andreas Lenshof et al.
Huong Thi Le et al.
Generating functional and perfusable micro-vascular networks is an important goal for the fabrication of large and three-dimensional tissues. Up to now, the fabrication of micro-vascular networks is a complicated multitask involving several...
Microfabrication and lab-on-a-chip devices promote in vitro modeling of neural interfaces for neuroscience researches and preclinical applications [0.03%]
微加工和芯片实验室设备促进用于神经科学研究和临床前应用的体外神经接口建模
Yang Liu,Xiangyun Yao,Cunyi Fan et al.
Yang Liu et al.
Neural tissues react to injuries through the orchestration of cellular reprogramming, generating specialized cells and activating gene expression that helps with tissue remodeling and homeostasis. Simplified biomimetic models are encouraged...