Radial constraint of plastically compressed human dermo-epidermal skin substitutes mitigates in vitro contraction and enhances structural maturity [0.03%]
Luca Pontiggia,Jessica Polak,Vanuchija Someswaran et al.
Luca Pontiggia et al.
Dermo-epidermal skin substitutes (DESS) offer a promising approach for treating full-thickness skin defects, but prolongedin vitroculture leads to significant contraction of the engineered tissue, particularly in the presence of an epiderma...
Yanhao Dong,Dong Wang,Junning Chen et al.
Yanhao Dong et al.
Blood-Brain Barrier (BBB) integrity is critical for central nervous system homeostasis and represents a key challenge for drug delivery. 3D bioprinting offers unprecedented control over architecture and cell organization in neurovascular mo...
Puskal Kunwar,Arun Poudel,Ujjwal Aryal et al.
Puskal Kunwar et al.
Despite technological advances, the fabrication of multiscale, multi-material, and topologically complex 3D structures using soft hydrogel biomaterials remains a challenge due to the inherent trade-offs between print size/resolution, biomat...
Bioresorbable fiber reinforced hydrogel scaffold for cartilage tissue regeneration [0.03%]
可降解纤维增强水凝胶软骨支架用于软骨组织修复
Yizi Ye,Liu Yang,Yuning Hua et al.
Yizi Ye et al.
Melt electrowriting (MEW) is an innovative additive manufacturing technology utilized for producing fibrous three-dimensional structures for tissue engineering and regenerative medicine applications. While polycaprolactone (PCL) is the pred...
AI-augmented ultrasound analysis of noninvasive quantification of hydrogels concentration for bioprinting [0.03%]
基于人工智能的超声波分析技术用于水凝胶生物打印浓度的无创量化检测
Cho Eun Lee,Juhyun Kang,Maaz Salman et al.
Cho Eun Lee et al.
Hydrogels, possessing biocompatibility and flexibility, are widely used across biomedical and industrial domains, with their concentration serving as a critical determinant of their physicochemical properties. However, conventional methods ...
Dynamic 3D in vitro platform engineered via low-cytotoxic DLP 3D printing for enhanced ovarian follicle culture [0.03%]
一种通过低细胞毒性的数字光线处理3D打印工程化而成的动态体外培养平台 可促进卵泡的体外长期高效培养
Jeong-Hun Kang,Min-Kyung Seo,Mi-Seon Park et al.
Jeong-Hun Kang et al.
To mimic thein vivoculture environment, anin vitroplatform should not only provide structural support but also recreate the cellular microenvironment. However, for enhanced cell growth and function, it is essential to incorporate a three-di...
Integrating traction force microscopy and finite element analysis to assess hiPSC-CM mechanics on micropatterned substrates [0.03%]
结合牵引力显微镜和有限元分析评估在微图案基底上的hiPSC-CM力学性能
Shayan Jannati,Yasaman Maaref,Yousef Javanmardi et al.
Shayan Jannati et al.
Traction force microscopy (TFM) is a well-established technique for quantifying the forces that cells exert on their underlying substrates. However, its application to dynamically beating cells-such as cardiomyocytes cultured as two-dimensi...
Engineering Cartilaginous Constructs by Integrating Umbilical Cord-Derived Mesenchymal Stem Cell Spheroids and Localized Mineral Ion Delivery in 3D Hydrogel [0.03%]
基于三维水凝胶的脐带间充质干细胞球体和局部矿化离子输送的软骨组织工程技术
Eunji Park,Eunjin Lee,Seung Jae Huh et al.
Eunji Park et al.
The engineering three-dimensional (3D) cartilage tissue from mesenchymal stem cells is often obstructed by diffusion limitations, uncontrolled signal delivery, and hypertrophic differentiation following chondrogenesis. We herein report a 3D...
A scale-down mini-Bioreactor for the acceleration of data-driven bioprocess optimisation in cell therapy [0.03%]
一种规模缩小的微型生物反应器，用于加速基于数据驱动的细胞治疗生物过程优化
Giuseppe Adriano Adriano Asaro,Ioannis Papantoniou,Jean-Marie Aerts
Giuseppe Adriano Adriano Asaro
Cell therapies have demonstrated great potential for treating a broad range of diseases where conventional treatments have failed. However, long development times and sub-optimal processing conditions often hinder their clinical translation...
High-fidelity 'top-down' DLP bioprinting of multi-material soft tissue constructs enabled by computer vision-based layer control [0.03%]
基于计算机视觉的层控制高保真“自上而下”DLP生物打印实现多材料软组织构建体
Nadina Usseglio,Alejandro González Santos,Alba Fernández Ferrer et al.
Nadina Usseglio et al.
Bioprinting continues to redefine the frontiers of regenerative medicine by enabling the fabrication of complex, three-dimensional (3D) tissue constructs that emulate native biological and mechanical functions. However, despite significant ...