3D bioprinting of stromal vascular fraction enriched with MXenes for enhanced intestinal regeneration [0.03%]
Giordano Perini,Antonio Minopoli,Giada Di Giulio et al.
Giordano Perini et al.
Intestinal disorders such as inflammatory bowel diseases and gastrointestinal fistulae are marked by chronic inflammation, barrier dysfunction, and impaired repair, conditions insufficiently addressed by current treatments. Regenerative str...
Advances in hemostatic sponges: from materials and biofabrication strategies to biomedical applications [0.03%]
止血海绵研究进展：从材料和生物制造策略到生物医学应用
Ting Qiao,Xiaoqin Si,Feng Sang et al.
Ting Qiao et al.
Hemorrhage remains one of the leading causes of trauma-related mortality worldwide and poses a major challenge in surgery, emergency medicine, and battlefield rescue. Conventional hemostatic materials, such as gauze and gelatin sponges, mai...
Viscoelasticity-tuned hyaluronic acid-gelatin microcarriers with thermoresponsive polymer grafts for scalable cell expansion and gentle harvesting [0.03%]
具有温度响应聚合物接枝的透明质酸-明胶微载体用于可扩展细胞扩增和温和收获
Rizka Musdalifah Amsar,Lin Xiangting,Jun-Sheng Wang et al.
Rizka Musdalifah Amsar et al.
Three-dimensional (3D) cell culture using microcarriers is an effective strategy for scalable cell expansion; however, conventional enzymatic detachment can compromise cell viability, surface proteins, and native signalling. We report visco...
Synergistic, shape-controlled endothelialized spheroid-hydrogel for wound healing [0.03%]
协同作用的内皮化类球-水凝胶伤口愈合敷料
Chunxiang Lu,Shuangying Zhong,Huazhen Liu et al.
Chunxiang Lu et al.
For healing full-thickness skin defects caused by severe injury, skin substitute grafts with structural and compositional biomimicry are critical. Vascularized spheroids, as highly active biological building blocks, can be applied in bioman...
Bioprinting of BSA membranes with C2C12 and NIH 3T3 pre-cellularized PLGA microscaffold : a step toward diaphragmatic hernia patches [0.03%]
预先细胞化的PLGA微支架的BSA膜生物打印：朝向膈疝补片一步
Mélissa Langlois,Adrien Rousselle,Shane Fennell et al.
Mélissa Langlois et al.
The diaphragm is a physical barrier separating the thoracic and abdominal cavities. Its physiological function is fundamental to pulmonary ventilation. Congenital diaphragmatic hernia (CDH) is a malformation that leaves a hole in the diaphr...
One-step coaxial bioprinting of aligned and vascularized 3D skeletal muscle constructs [0.03%]
一步式共轴生物打印排列整齐且具有血管的三维骨骼肌构建体
Yeonjin Hong,Hyeongu Lim,Hyungseok Lee
Yeonjin Hong
Skeletal muscle constitutes approximately 40-50% of total body weight and plays a vital role in human physiology; however, its regenerative capacity is insufficient in cases of volumetric muscle loss, and effective therapeutic options remai...
A cleanroom-free membrane-integrated organ-on-a-chip platform for rapid intestinal tissue formation [0.03%]
一种无洁净室要求的膜整合芯片器官平台用于快速形成肠组织
Sara Hassanpour Tamrin,Sorosh Abdollahi,Amir Sanati Nezhad et al.
Sara Hassanpour Tamrin et al.
Polydimethylsiloxane (PDMS)-based organ-on-a-chip (OoC) platforms typically rely on cleanroom photolithography, custom masks, and master molds, which limit their accessibility and impede rapid prototyping efforts. Here, we present a simple,...
Human iPSC-derived vascularized organoids: Strategy-based insights from 2D endothelial cells to 3D blood vessel organoids [0.03%]
基于策略的洞见：从二维内皮细胞到三维血管器官样体
Seo-Yeon Kong,Da-Hyun Kim
Seo-Yeon Kong
Organoids derived from human pluripotent stem cells (PSCs) have emerged as powerful in vitro models for studying development, disease, and therapeutic responses, yet their lack of functional vasculature limits growth, maturation, and physio...
Gravity-driven microfluidic synthesis of lipid nanoparticles via vibrating sharp-tip mixing [0.03%]
重力驱动的振动尖端混合型微流控技术合成脂质纳米颗粒
Toktam Godary,Zhengru Liu,Peng Li
Toktam Godary
Lipid nanoparticles (LNPs) are widely used in nanomedicine, yet their energy-efficient manufacture with precise control over particle uniformity remains challenging. Here we report a gravity-driven microfluidic platform that integrates acou...
High-throughput design of 3D hybrid stem cell spheroids loaded with zinc-doped urchin-like hydroxyapatite and their osteopromotive bionics [0.03%]
高通量设计锌掺杂海胆状羟基磷灰石载入的三维混合干细胞球体及其促骨组织工程生物效应
Hongmei Liu,Lei Zhou,Jianxin Ye et al.
Hongmei Liu et al.
Stem cell spheroids, as an advanced platform in cell therapy, have shown great potential for improving therapeutic efficacy through enhanced cell-cell and cell-microenvironment interactions. Meanwhile, zinc-based biomaterials are attracting...