Engineered Heart Tissues formed with Cardiac Progenitors and Differentiated Cardiomyocytes exhibit similar Physiologic Properties at Differentiation-Matched Timepoints [0.03%]
心脏祖细胞和分化心肌细胞形成的心组织在分化匹配时间点表现出类似的生理特性
Lavanya Aryan,Jennifer A E Esteves,James Tabor et al.
Lavanya Aryan et al.
Congenital heart diseases (CHD), including single ventricle heart defects such as hypoplastic left and right heart syndromes, remain a leading cause of neonatal death and long-term morbidity. Regenerative medicine approaches hold great ther...
Reimagining bioprinters: real-time monitoring for quality control of bioprinted constructs and future vision [0.03%]
重构生物打印机：用于实时监测生物打印结构质量的当前方法和未来展望
Alicia Adina Matavosian,Lawrence Bonassar
Alicia Adina Matavosian
The use of bioprinters as depositional tools for bioinks and cells has expanded greatly over the past two decades. Bioprinting combines hydrogels with cells to produce customized constructs for personalized medicine. However, several challe...
3D TPMS curvature accelerated osteogenesis by enhancing permeability and directing cell orientation [0.03%]
各向异性多孔支架促进细胞排列及扩散从而加速TPMS模型曲率诱导的骨组织工程血管化研究
Jiamian Han,Heming Chen,Jiayi Li et al.
Jiamian Han et al.
The curvature of cell adhesion substrates has emerged as a critical geometric parameter influencing cellular fate determination. While its regulatory role is increasingly recognized, the osteogenic effects of complex three-dimensional curve...
Liver-on-Micropillar: A Humanized, Animal-Free Platform for High-Throughput Assessment of Drug-Induced Liver Injury [0.03%]
肝微柱(Liver-on-Micropillar):一种无动物且人类药物致肝损伤高通量评估平台
Ahmed S M S M Ali,Dongwei Wu,Viola Röhrs et al.
Ahmed S M S M Ali et al.
Drug-induced liver injury (DILI) remains a major cause of acute liver failure, clinical trial attrition, and post-marketing drug withdrawal, yet predictive in vitro models are limited in accuracy, scalability, and human relevance. Here, we ...
From Organ to System: Multiorgan-on-a-Chip Platforms as Next-Generation Biomedical Simulators [0.03%]
从器官到系统：多器官芯片平台作为下一代生物医学模拟器
Chen Chen,Lin Zhou,Ni Kou et al.
Chen Chen et al.
Organs in the human body exist within a highly integrated and dynamically interacting environment, and their interactions are critical for maintaining normal physiological processes. Traditional cell culture models and animal models fail to...
Biofabrication of an Ovine Intervertebral Disc Model by Combining a Polycaprolactone Frame with a Bioprinted Alginate Hydrogel [0.03%]
结合聚己内酯框架和生物打印海藻酸盐水凝胶构建羊椎间盘模型的制造研究
Emmaelle Carrot,Mansoor Chaaban,Daronne Contreras et al.
Emmaelle Carrot et al.
The intervertebral disc (IVD) primarily comprises an outer ring of collagen fibers (annulus fibrosus, AF), which encases a soft, gelatinous core (nucleus pulposus, NP). Existing in vitro models have failed to integrate these two tissues eff...
Tumor organoid and tumor-on-a-chip equipped next generation precision medicine [0.03%]
装备肿瘤器官体和肿瘤芯片的下一代精准医疗
Wentao Zhao,Zilin Zhang,Shihui Xu et al.
Wentao Zhao et al.
Recently, significant advancements have been witnessed in various in vitro treatment evaluation models, especially organoids and organs-on-chips. In vitro culture of cancer cells and drug screening are key technical components in functional...
Tailoring agarose fluid gels for use in suspension bath bioprinting and culture of spheroid-based bioinks [0.03%]
用于悬浮浴生物打印和基于球体的生物墨水培养的琼脂糖流体凝胶的设计
Megan Elin Cooke,Nikolas Di Caprio,Jason P Killgore et al.
Megan Elin Cooke et al.
Suspension bath bioprinting, whereby bioinks are extruded into a yield stress bath with rapid recovery from shearing, has enabled the printing of low viscosity bioinks into constructs with high geometric complexity. This is particularly use...
Sara Romanazzo,Peilin Tian,Gagan Jalandhra et al.
Sara Romanazzo et al.
Breast cancer progression is a consequence of intricate dynamics between cells and their matrix in the tumor microenvironment. However, most in vitro models are not amenable to studying the behavior of multiple cell types within a defined m...
Influence of viscosity on bone marrow-derived mesenchymal stem cells trilineage differentiation during 3D culture [0.03%]
黏度对三维培养体系中骨髓间充质干细胞三系分化的影响研究
Chengyu Lu,Jing Zheng,Tianjiao Zeng et al.
Chengyu Lu et al.
Stem cells can respond to mechanical stimuli such as stiffness, viscoelasticity, fluid shear stress, micropatterned geometry and hydraulic pressure. However, viscosity as an important cue is often overlooked. Thus, in this study, the influe...