Sensor macrophages derived from human induced pluripotent stem cells to assess pyrogenic contaminations in parenteral drugs [0.03%]
用于检测注射药物中致热污染物的人诱导多能干细胞源性传感器巨噬细胞
Shifaa M Abdin,Friederike Mansel,Anna Rafiei Hashtchin et al.
Shifaa M Abdin et al.
Ensuring the safety of parenteral drugs before injection into patients is of utmost importance. New regulations around the globe and the need to refrain from using animals however, have highlighted the need for new cell sources to be used i...
Biomimetic gradient scaffolds for the tissue engineering and regeneration of rotator cuff enthesis [0.03%]
用于肩袖肌腱结合部组织工程和再生的仿生梯度支架
Yang Chen,Yexin Li,Weihong Zhu et al.
Yang Chen et al.
Rotator cuff tear is one of the most common musculoskeletal disorders, which often results in recurrent shoulder pain and limited movement. Enthesis is a structurally complex and functionally critical interface connecting tendon and bone th...
Maximization of uricase production in a column bioreactor through response surface methodology-based optimization [0.03%]
基于响应面法的柱式生物反应器内尿酸酶生产的最优化研究
Mohammad Hossein Taghizadeh,Khosro Khajeh,Niloofar Nasirpour et al.
Mohammad Hossein Taghizadeh et al.
Uricase (EC 1.7.3.3) is an oxidoreductase enzyme that is widely exploited for diagnostic and treatment purposes in medicine. This study focuses on producing recombinant uricase fromE. coliBL21 in a bubble column bioreactor (BCB) and finding...
Fuxiao Wang,Peiran Song,Jian Wang et al.
Fuxiao Wang et al.
Organoids have emerged as crucial platforms in tissue engineering and regenerative medicine but confront challenges in faithfully mimicking native tissue structures and functions. Bioprinting technologies offer a significant advancement, es...
Functionally graded hydrogels with opposing biochemical cues for osteochondral tissue engineering [0.03%]
具有相反生化信号的功能梯度水凝胶软骨组织工程中的应用研究
Aman Mahajan,Zahra Sifat Zaidi,Amit Shukla et al.
Aman Mahajan et al.
Osteochondral tissue (OC) repair remains a significant challenge in the field of musculoskeletal tissue engineering. OC tissue displays a gradient structure characterized by variations in both cell types and extracellular matrix components,...
Advancements in gradient bone scaffolds: enhancing bone regeneration in the treatment of various bone disorders [0.03%]
梯度骨支架的进展：增强骨再生以治疗各种骨病变
Chengdong Zhen,Yanbin Shi,Wenguang Wang et al.
Chengdong Zhen et al.
Bone scaffolds are widely employed for treating various bone disorders, including defects, fractures, and accidents. Gradient bone scaffolds present a promising approach by incorporating gradients in shape, porosity, density, and other prop...
The influence of spheroid maturity on fusion dynamics and micro-tissue assembly in 3D tumor models [0.03%]
类球体成熟度对三维肿瘤模型融合动力学和微组织组装的影响
Rong Pan,Chenyu Lin,Xiaoyan Yang et al.
Rong Pan et al.
Three-dimensional (3D) cell culture has been used in many fields of biology because of its unique advantages. As a representative of the 3D systems, 3D spheroids are used as building blocks for tissue construction. Larger tumor aggregates c...
Biochemical and immunomodulatory insights of extracellular matrix from decellularized human whole cervix: recellularization and in vivo ECM remodeling interplay [0.03%]
去细胞化整个人宫颈的细胞外基质的生化和免疫调节作用的新见解：再细胞化与体内ECM重塑的相互作用
Atul Kumar Ojha,Ragavi Rajasekaran,Arman Kunwar Hansda et al.
Atul Kumar Ojha et al.
Extracellular matrix (ECM) rich whole organ bio-scaffolds, preserving structural integrity and essential growth factors, has potential towards regeneration and reconstruction. Women with cervical anomalies or trauma can benefit from clinica...
Francesco Piraino,Mariana Costa,Marine Meyer et al.
Francesco Piraino et al.
High failure rates of the current drug development process are driving exemplary changes toward methodologies centered on human diseasein-vitromodeling. Organoids are self-organized tissue sub-units resembling their organ of origin and are ...
Pulsed electromagnetic field-assisted reduced graphene oxide composite 3D printed nerve scaffold promotes sciatic nerve regeneration in rats [0.03%]
脉冲电磁场辅助的还原氧化石墨烯复合三维打印神经支架促进大鼠坐骨神经再生
Zichao Wang,Shijun Li,Zongxi Wu et al.
Zichao Wang et al.
Peripheral nerve injuries can lead to sensory or motor deficits that have a serious impact on a patient's mental health and quality of life. Nevertheless, it remains a major clinical challenge to develop functional nerve conduits as an alte...