3D bioprinting platform development for high-throughput cancer organoid models construction and drug evaluation [0.03%]
一种用于高通量类器官模型构建和药物评价的3D生物打印平台的开发
Rui Dai,Wei Chen,You Chen et al.
Rui Dai et al.
The evaluation of anti-tumor drugs is critical for their development and clinical guidance. Tumor organoid models are gaining increased attention due to their ability to better mimic real tumor tissues, as well as lower time and economic co...
Fabrication of 3D engineered intestinal tissue producing abundant mucus by air-liquid interface culture using paper-based dual-layer scaffold [0.03%]
基于纸基双层支架的空气液界面培养用于构建能够产生丰富黏液的三维工程化肠组织
Mari Nagasawa,Mai Onuki,Natsuki Imoto et al.
Mari Nagasawa et al.
Fabrication of engineered intestinal tissues with the structures and functions as humans is crucial and promising as the tools for developing drugs and functional foods. The aim of this study is to fabricate an engineered intestinal tissue ...
Silk fibroin increases the elasticity of alginate-gelatin hydrogels and regulates cardiac cell contractile function in cardiac bioinks [0.03%]
丝素蛋白可增加藻酸盐-明胶水凝胶弹性并调节心脏生物墨水中心肌细胞收缩功能
L Vettori,H A Tran,H Mahmodi et al.
L Vettori et al.
Silk fibroin (SF) is a natural protein extracted fromBombyx morisilkworm thread. From its common use in the textile industry, it emerged as a biomaterial with promising biochemical and mechanical properties for applications in the field of ...
A cell bank paradigm for preclinical evaluation of an analogous cellular product for an allogeneic cell therapy [0.03%]
同种异体细胞疗法类似细胞产品非临床评价的细胞库范式
Rachel C Nordberg,Ryan P Donahue,M Gabriela Espinosa et al.
Rachel C Nordberg et al.
Toward the translation of allogeneic cell therapy products, cell banks are needed not only to manufacture the final human product but also during the preclinical evaluation of an animal-based analogous cellular product (ACP). These cell ban...
Basic models to advanced systems: harnessing the power of organoids-based microphysiological models of the human brain [0.03%]
从基础模型到高级系统：利用类脑器官微生理模型的力量
Katherine Boylin,Grace V Aquino,Michael Purdon et al.
Katherine Boylin et al.
Understanding the complexities of the human brain's function in health and disease is a formidable challenge in neuroscience. While traditional models like animals offer valuable insights, they often fall short in accurately mirroring human...
Droplet bioprinting of acellular and cell-laden structures at high-resolutions [0.03%]
高分辨率的无细胞和含细胞结构的液滴生物打印技术
Puskal Kunwar,Ujjwal Aryal,Arun Poudel et al.
Puskal Kunwar et al.
Advances in digital light projection(DLP) based (bio) printers have made printing of intricate structures at high resolution possible using a wide range of photosensitive bioinks. A typical setup of a DLP bioprinter includes a vat or reserv...
hiPSC-derived macrophages improve drug sensitivity and selectivity in a macrophage-incorporating organoid culture model [0.03%]
基于hiPSC的巨噬细胞能改善含巨噬细胞类器官培养模型的药物敏感性和选择性
Seongyea Jo,Sung Bum Park,Hyemin Kim et al.
Seongyea Jo et al.
Accurate simulation of different cell type interactions is crucial for physiological and precisein vitrodrug testing. Human tissue-resident macrophages are critical for modulating disease conditions and drug-induced injuries in various tiss...
Vascular dysfunction in hemorrhagic viral fevers: opportunities for organotypic modeling [0.03%]
出血性病毒发热的血管功能障碍：器官型建模的机会
Evelyn Zarate-Sanchez,Steven C George,Monica L Moya et al.
Evelyn Zarate-Sanchez et al.
The hemorrhagic fever viruses (HFVs) cause severe or fatal infections in humans. Named after their common symptom hemorrhage, these viruses induce significant vascular dysfunction by affecting endothelial cells, altering immunity, and disru...
Pillar electrodes embedded in the skeletal muscle tissue for selective stimulation of biohybrid actuators with increased contractile distance [0.03%]
嵌入骨骼肌组织中的支柱电极，用于选择性刺激具有更长收缩距离的生物杂交致动器
Tingyu Li,Minghao Nie,Yuya Morimoto et al.
Tingyu Li et al.
Electrodes are crucial for controlling the movements of biohybrid robots, but their external placement outside muscle tissue often leads to inefficient and non-selective stimulation of nearby biohybrid actuators. To address this, we propose...
Biofabrication of 3D adipose tissue via assembly of composite stem cell spheroids containing adipo-inductive dual-signal delivery nanofibers [0.03%]
含诱导脂肪生成双重信号递送纳米纤维的复合干细胞球体组装制备三维脂肪组织
Sangmin Lee,Jeongbok Lee,Soomi Choi et al.
Sangmin Lee et al.
Reconstruction of large 3D tissues based on assembly of micro-sized multi-cellular spheroids has gained attention in tissue engineering. However, formation of 3D adipose tissue from spheroids has been challenging due to the limited adhesion...