Cancer cell migration depends on adjacent ASC and adipose spheroids in a 3D bioprinted breast cancer model [0.03%]
一种三维生物打印的乳腺癌模型中，癌细胞迁移依赖于邻近的ASC和脂肪小体球形结构
Hannes Horder,David Böhringer,Nadine Endrizzi et al.
Hannes Horder et al.
Breast cancer develops in close proximity to mammary adipose tissue and interactions with the local adipose environment have been shown to drive tumor progression. The specific role, however, of this complex tumor microenvironment in cancer...
3D embedded bioprinting of large-scale intestine with complex structural organization and blood capillaries [0.03%]
具有复杂结构组织和毛细血管的大规模肠道的三维植入式生物打印
Yuxuan Li,Shengnan Cheng,Haihua Shi et al.
Yuxuan Li et al.
Accurate reproduction of human intestinal structure and functionin vitrois of great significance for understanding the development and disease occurrence of the gut. However, mostin vitrostudies are often confined to 2D models, 2.5D organ c...
Katharina T Kroll,Kimberly A Homan,Sebastien G M Uzel et al.
Katharina T Kroll et al.
The ability to controllably perfuse kidney organoids would better recapitulate the native tissue microenvironment for applications ranging from drug testing to therapeutic use. Here, we report a perfusable, vascularized kidney organoid on c...
Assessment and process optimization of high throughput biofabrication of immunocompetent breast cancer model for drug screening applications [0.03%]
高通量生物制造免疫 competent乳腺癌模型的评估与工艺优化用于药物筛选应用
Priyanshu Shukla,Ashis Kumar Bera,Amit Ghosh et al.
Priyanshu Shukla et al.
Recent advancements in 3D cancer modeling have significantly enhanced our ability to delve into the intricacies of carcinogenesis. Despite the pharmaceutical industry's substantial investment of both capital and time in the drug screening a...
A 3D-printed tumor-on-chip: user-friendly platform for the culture of breast cancer spheroids and the evaluation of anti-cancer drugs [0.03%]
一种用于培养乳腺癌类器官和抗癌药物评价的3D打印肿瘤芯片平台
Salvador Gallegos-Martínez,David Choy-Buentello,Kristen Aideé Pérez-Álvarez et al.
Salvador Gallegos-Martínez et al.
Tumor-on-chips (ToCs) are useful platforms for studying the physiology of tumors and evaluating the efficacy and toxicity of anti-cancer drugs. However, the design and fabrication of a ToC system is not a trivial venture. We introduce a use...
Development of an organ-on-chip model for the detection of volatile organic compounds as potential biomarkers of tumour progression [0.03%]
一种用于检测挥发性有机化合物作为潜在肿瘤进展生物标志物的器官芯片模型的发展
Clara Bayona,Magdalena Wrona,Teodora Ranđelović et al.
Clara Bayona et al.
Early detection of tumours remains a significant challenge due to their invasive nature and the limitations of current monitoring techniques. Liquid biopsies have emerged as a minimally invasive diagnostic approach, wherein volatile organic...
Human iPSC-derived liver co-culture spheroids to model liver fibrosis [0.03%]
人诱导多能干细胞来源的肝细胞共培养类器官用于肝纤维化模型
Laura Cools,Mina Kazemzadeh Dastjerd,Ayla Smout et al.
Laura Cools et al.
The lack of adequate humanin vitromodels that recapitulate the cellular composition and response of the human liver to injury hampers the development of anti-fibrotic drugs. The goal of this study was to develop a human spheroid culture mod...
Beyond stiffness: deciphering the role of viscoelasticity in cancer evolution and treatment response [0.03%]
超越刚度：解析粘弹性在癌症进化和治疗反应中的作用
Ana Zubiarrain-Laserna,Daniel Martínez-Moreno,Julia Lopez de Andres et al.
Ana Zubiarrain-Laserna et al.
There is increasing evidence that cancer progression is linked to tissue viscoelasticity, which challenges the commonly accepted notion that stiffness is the main mechanical hallmark of cancer. However, this new insight has not reached wide...
3D bioprinting of dense cellular structures within hydrogels with spatially controlled heterogeneity [0.03%]
空间异质性控制下的水凝胶内密集细胞结构的三维生物打印技术
Alperen Abaci,Murat Guvendiren
Alperen Abaci
Embedded bioprinting is an emerging technology for precise deposition of cell-laden or cell-only bioinks to construct tissue like structures. Bioink is extruded or transferred into a yield stress hydrogel or a microgel support bath allowing...
Development of a biofabricated 3D in vitro vessel model for investigating transendothelial migration in stem cell therapy [0.03%]
开发用于干细胞治疗中血管迁移研究的三维体外模型血管系统
Mattis Wachendörfer,Alena Lisa Palkowitz,Horst Fischer
Mattis Wachendörfer
Systemic stem cell therapies hold promise for treating severe diseases, but their efficiency is hampered by limited migration of injected stem cells across vascular endothelium towards diseased tissues. Understanding transendothelial migrat...