Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors [0.03%]
用于增强生物墨水和3D生物打印组织前体中营养供应的静电纺微纤维
A Neuhäusler,K Rogg,S Schröder et al.
A Neuhäusler et al.
3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to...
Cell membrane-camouflaged nanoparticles activate fibroblast-myofibroblast transition to promote skin wound healing [0.03%]
细胞膜伪装的纳米颗粒激活成纤维细胞-肌成纤维细胞转化以促进皮肤伤口愈合
Qi Jia,Yijuan Ding,Ziwen Su et al.
Qi Jia et al.
The fibroblast-myofibroblast transition marked by extracellular matrix (ECM) secretion and contraction of actomyosin-based stress fibers, plays central roles in the wound healing process. This work aims to utilize the cell membrane-based na...
Multidimensional nanofibrous hydrogels integrated triculture system for advanced myocardial regeneration [0.03%]
用于先进心肌再生的多维纳米纤维素水凝胶集成三培养系统
Dongwoo Kim,Yeong Hwan Kim,Gyubok Lee et al.
Dongwoo Kim et al.
Myocardial infarction (MI) remains a leading cause of mortality worldwide, posing a significant challenge to healthcare systems. The limited regenerative capacity of cardiac tissue following MI results in chronic cardiac dysfunction, highli...
Elizabeth McDonough,Margarida Barroso,Fiona Ginty et al.
Elizabeth McDonough et al.
Reduced therapy response in breast cancer has been correlated with heterogeneity in biomarker composition, expression level, and spatial distribution of cancer cells within a patient tumor. Thus, there is a need for models to replicate cell...
Nanoliposome functionalized colloidal GelMA inks for 3D printing of scaffolds with multiscale porosity [0.03%]
用于多尺度孔隙支架3D打印的纳米脂质体功能化胶原诱导凝胶甲基丙烯酰胺墨水
Elaheh Omidvari,Mohamadmahdi Samandari,Delaram Ghanbariamin et al.
Elaheh Omidvari et al.
Bioprinting has enabled the creation of intricate scaffolds that replicate the physical, chemical, and structural characteristics of natural tissues. Recently, hydrogels have been used to fabricate such scaffolds for several biomedical appl...
Development of immunocompetent full thickness skin tissue constructs to model skin fibrosis for high-throughput drug screening [0.03%]
用于高通量药物筛选的皮肤纤维化模型的免疫competent全厚度皮肤组织构建的发展
Yi Wei Lim,Russell Quinn,Kapil Bharti et al.
Yi Wei Lim et al.
The lack of the immune component in most of the engineered skin models remains a challenge to study the interplay between different immune and non-immune cell types of the skin. Immunocompetent humanin vitroskin models offer potential advan...
Engineering pore-enriched and pre-vascularized volumetric constructs for enhanced blood glucose regulation in type 1 diabetes therapy [0.03%]
工程孔丰富和预血管化体积构建以增强1型糖尿病治疗中的血糖调节能力
Jaewook Kim,In Kyong Shim,Yu Na Lee et al.
Jaewook Kim et al.
Managing type 1 diabetes mellitus (T1DM) presents significant challenges because of the complexity of replicating the microenvironment of pancreatic islets and ensuring the long-term viability and function of transplanted insulin-producing ...
High-throughput formulation of reproducible 3D cancer microenvironments for drug testing in myeloid leukemia [0.03%]
用于髓系白血病药物测试的可重复性三维癌症微环境的高通量配方
M Rudzinska-Radecka,L Turos-Korgul,D Mukherjee et al.
M Rudzinska-Radecka et al.
Leukemic microenvironment has been recognized as a factor that strongly supports the mechanisms of resistance. Therefore, targeting the microenvironment is currently one of the major directions in drug development and preclinical studies in...
A digital manufactured microfluidic platform for flexible construction of 3D co-culture tumor model with spatiotemporal resolution [0.03%]
一种数字化制造的微流控平台，可灵活构建具有时空分辨率的三维共培养肿瘤模型
Chao Han,Renchao Zhang,Xiwen He et al.
Chao Han et al.
The specific spatiotemporal distribution of diverse components in tumor microenvironment plays a crucial role in the cancer progression.In vitrothree-dimensional (3D) tumor models with polydimethylsiloxane (PDMS) based microfluidic platform...
Soft-lithographically defined template for arbitrarily patterned acoustic bioassembly [0.03%]
用于任意图案化声学生物组装的软光刻模板
Sihan Chen,Lili Zhu,Jibo Wang et al.
Sihan Chen et al.
Acoustic bioassembly is recently regarded as a highly efficient biofabrication tool to generate functional tissue mimics. Despite their capacity of directly patterning live cells with close intercellular proximity, most acoustic bioassembly...