Half the price, twice the gain: How to simultaneously decrease animal numbers and increase precision with good experimental design [0.03%]
减半的代价，双倍的收益：良好的实验设计如何同时减少动物使用并提高精确度
Servan Luciano Grüninger,Florian Frommlet
Servan Luciano Grüninger
Animal research often involves experiments in which the effect of several factors on a particular outcome is of scientific interest. Many researchers approach such experiments by varying just one factor at a time. As a consequence, they des...
Simulation methodologies to determine statistical power in laboratory animal research studies [0.03%]
实验动物研究中确定统计功效的模拟方法学
Angela Jeffers,Kathryn Konrad,Gary Larson et al.
Angela Jeffers et al.
Null hypothesis significance testing is a statistical tool commonly employed throughout laboratory animal research. When experimental results are reported, the reproducibility of the results is of utmost importance. Establishing standard, r...
Guidance on the assessment of learning outcomes for those designing procedures and projects - Report of an ETPLAS Working Group [0.03%]
学习成果评估指南——专家组工作报告
Ismene A Dontas,Derek J Fry,David I Lewis et al.
Ismene A Dontas et al.
This document provides assessment criteria for evaluation of each of the Learning Outcomes of the Modules specified (in addition to the Core Modules) for those designing procedures and projects in the Education and Training Framework guidan...
Incorporating sources of correlation between outcomes: An introduction to mixed models [0.03%]
引入相关结果的来源：混合模型简介
Limeng Liu,Ashley Petersen
Limeng Liu
Animal research often involves measuring the outcomes of interest multiple times on the same animal, whether over time or for different exposures. These repeated outcomes measured on the same animal are correlated due to animal-specific cha...
Bayesian statistical concepts with examples from rodent toxicology studies [0.03%]
利用毒理学研究实例讲解贝叶斯统计概念
Gary J Larson,Keith R Shockley
Gary J Larson
The theory and practice of statistics comprises two main schools of thought: frequentist statistics and Bayesian statistics. Frequentist methods are most commonly used to analyze animal-based laboratory data, while Bayesian statistical meth...
Non-invasive acquisition of vital data in anesthetized rats using laser and radar application [0.03%]
基于激光和雷达技术的麻醉大鼠生命体征无创采集方法
Toshiaki Kawabe,Shota Kita,Isao Ohmura et al.
Toshiaki Kawabe et al.
The aim of this study was to verify the possibility of obtaining vital sign information using a laser and radar sensor in a manner that is non-invasive and painless for test animals. A dataset was obtained from respiratory movement of anaes...
Murine astrovirus (MuAstV) infection in mouse facilities in Brazil: First South American report [0.03%]
巴西小鼠饲养设施中的鼠Astrovirus(MuAstV)感染：南美首报
Marcia S C Oliveira,Tatiana X Castro,Camila F Baez et al.
Marcia S C Oliveira et al.
This study aimed to investigate the presence of murine astrovirus (MuAstV) in Brazil. Fecal samples from mice belonging to four Brazilian animal facilities were collected and tested for MuAstV using real-time polymerase chain reaction. Of t...
Naomi Altman,Martin Krzywinski
Naomi Altman
Variability is inherent in most biological systems due to differences among members of the population. Two types of variation are commonly observed in studies: differences among samples and the "error" in estimating a population parameter (...
Animal models for preventing seroma after surgery: a systematic review and meta-analysis [0.03%]
预防术后血清肿动物模型的系统评价和meta分析
Steven E M Poos,Bob P Hermans,Harry van Goor et al.
Steven E M Poos et al.
Novel interventions for seroma prevention are urgently needed in clinical practice. Animal models are pivotal tools for testing these interventions; however, a significant translational gap persists between clinical and animal model outcome...