Jordi L Tremoleda
Jordi L Tremoleda
P S Verhave,R van Eenige,Iacw Tiebosch
P S Verhave
Blinding and randomisation are important methods for increasing the robustness of pre-clinical studies, as incomplete or improper implementation thereof is recognised as a source of bias. Randomisation ensures that any known and unknown cov...
Romain-Daniel Gosselin,Penny S Reynolds
Romain-Daniel Gosselin
Penny S Reynolds
Penny S Reynolds
Statistically based experimental designs have been available for over a century. However, many preclinical researchers are completely unaware of these methods, and the success of experiments is usually equated only with 'p < 0.05'. By contr...
Maya J Bodnar,I Joanna Makowska,Courtney T Boyd et al.
Maya J Bodnar et al.
Isoflurane anesthesia prior to carbon dioxide euthanasia is recognized as a refinement by many guidelines. Facilities lacking access to a vaporizer can use the "drop" method, whereby liquid anesthetic is introduced into an induction chamber...
Establishment of reference intervals of haematology and biochemistry analytes in ICR mice of different ages [0.03%]
不同年龄段ICR小鼠血液学和生化指标的参考区间建立
Suresh Patel,Satish Patel,Ashvin Kotadiya et al.
Suresh Patel et al.
Outbred stocks of mice are widely used in pre-clinical research as these animals possess a diversified genetic background when compared with inbred strains of mice. It is crucial to assess particular alterations in the physiological and fun...
Jacketed telemetry in rats: a novel non-invasive method for cardiorespiratory phenotyping during treadmill exercise [0.03%]
大鼠夹克式遥测法：运动时非侵入性心肺表型分析的新方法
Stéphane Tanguy,Agathe Cambier,Leandro Fontana-Pires et al.
Stéphane Tanguy et al.
The development of alternative methods for monitoring cardiorespiratory function without restraint or surgical implantation is attracting growing interest for both ethical and scientific reasons. For this purpose, a new non-invasive jackete...
Naomi Altman,Martin Krzywinski
Naomi Altman
P-values combined with estimates of effect size are used to assess the importance of experimental results. However, their interpretation can be invalidated by selection bias when testing multiple hypotheses, fitting multiple models or even ...
How cage effects can hurt statistical analyses of completely randomized designs [0.03%]
笼效应如何损害完全随机设计的统计分析
Reid D Landes
Reid D Landes
Cage effects: some researchers worry about them, some don't, and some aren't even aware of them. When statistical analyses do not account for cage effects, there is real reason to worry. Regardless of researchers' worries or lack thereof, a...
Bernhard Voelkl,Hanno Würbel
Bernhard Voelkl
Heterogeneity of study samples is ubiquitous in animal experiments. Here, we discuss the different options of how to deal with heterogeneity in the statistical analysis of a single experiment. Specifically, data from different sub-groups (e...