Management of zoonoses in research institutions - lessons learned from a Coxiella burnetii outbreak case [0.03%]
实验机构的人畜共患病管理——从库克斯体暴发事件中获得的经验教训
Pia Ks Ostach,André Dülsner,Anne Keil et al.
Pia Ks Ostach et al.
When biomedical research investigates the human surgical situation in the need of a chronic course, it is more often possible to do so using large animal models. The use of farm animals always poses special challenges for the institution co...
Extended oxygen supplementation after thoracotomy in rats may improve welfare [0.03%]
大鼠开胸术后延长供氧可能提高其福利指标
Bryony Few,Alex Dugdale
Bryony Few
A retrospective comparison of welfare indicators in male rats undergoing thoracotomy for intrapleural dosing is presented. The initial cohort (n = 7) breathed room air after recovery from anaesthesia, while later cohorts (n = 12) had oxygen...
An innovative approach for health and safety training and occupational health program annual enrollment for laboratory animal care and use personnel [0.03%]
实验动物管理和使用人员的健康安全培训和职业健康年度注册的新方法
Scott J Patlovich,Robert J Emery,Kristin G King et al.
Scott J Patlovich et al.
Animal care and use personnel in research laboratory facilities are inherently exposed to a variety of workplace hazards. The health and safety of the workforce working directly with or around research animals is of paramount importance, an...
Animal researchers' views on the publication of negative results and subsequent policy adoptions [0.03%]
动物研究人员对发表负面试验结果及其相关政策采用的观点
Carlos Oscar S Sorzano,Daniel G Hamilton,Eva Mendez
Carlos Oscar S Sorzano
For over a decade, the non-publication of negative results from preclinical studies has been identified as a significant concern in biomedical research. Such underreporting is considered a contributor to the reproducibility crisis in the fi...
Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis) [0.03%]
非洲爪蟾(Xenopus laevis)的自发性肝细胞和胃肿瘤
Bernat Martí-García,Simon L Priestnall,Yolanda Saavedra Torres et al.
Bernat Martí-García et al.
Three seven-year-old African clawed frogs (Xenopus laevis) from an animal research facility showed weight loss, coelomic distention and an abnormal swimming gait were euthanised on welfare grounds. A complete necropsy of each animal showed ...
Single nucleotide polymorphism (SNP) characterisation of mouse inbred strains bred at MRC-National Institute for Medical Research [0.03%]
医学研究理事会国家医学研究所饲养的小鼠近交系的单核苷酸多态性特征分析
José M Sánchez-Morgado
José M Sánchez-Morgado
Inbred mouse strains have long proved useful as tools for biomedical research. They remove the effects of genetic background as an experimental variable. Within all mouse colonies, genetic drift is a recognised phenomenon and monitoring and...
Development of a center for automated equipment processing to transform the research enterprise configuration [0.03%]
自动化设备处理中心的发展，以转变研究企业架构配置
Philip J Richter Jr,Albert LeClair,Harry Lim
Philip J Richter Jr
The strategy of centralizing equipment sanitation and processing was developed by a top-tier public university to address the growing physical infrastructure and human resource challenges of its expanding in-vivo research enterprise. Subseq...
Comparison of inferior vena cava puncture under continuous cardiac perfusion with cardiac puncture in blood acquisition of the laboratory mouse [0.03%]
连续心排液下鼠尾静脉穿刺与心脏穿刺采血法的比较研究
Wengang Hu,Hao Sheng,JiaCai Yang et al.
Wengang Hu et al.
Obtaining sufficient blood volume from mice significantly facilitates experimental research. This study explored the inferior vena cava puncture under continuous cardiac perfusion (IVCP-UCCP) technique and evaluated its efficiency in compar...
Myhailo Reshetnykov,Karen Stumm,Michael Zwick et al.
Myhailo Reshetnykov et al.
Facilities involved in laboratory animal research often face ethical challenges such as: what should I do with the animals that are no longer suitable for experimental purposes? One of the common answers to this question is to kill them. An...
Romain-Daniel Gosselin
Romain-Daniel Gosselin
The normality assumption postulates that empirical data derives from a normal (Gaussian) population. It is a pillar of inferential statistics that enables the theorization of probability functions and the computation of p-values thereof. Th...